A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription
- Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, F-67404 ILLKIRCH Cedex, CU de Strasbourg, France
This extract was created in the absence of an abstract.
Initiation of transcription by RNA polymerase II (Pol II) requires general transcription factors to assemble the Pol II pre-initiation complex (PIC) (Hampsey 1998). PIC assembly on both TATA-containing and TATA-less promoters can be nucleated by the general transcription factors TFIID or B-TFIID, which are comprised of the TATA-binding protein (TBP) and TBP-associated factors (TAFIIs) (Bell and Tora 1999; Albright and Tjian 2000). More than 10 years ago, the first TAFIIs were discovered inDrosophila and in human cells (Dynlacht et al. 1991; Tanese et al. 1991). These proteins were identified in biochemically stable complexes with …
