Keystone meeting summary: ‘Adipogenesis, obesity, and inflammation’ and ‘Diabetes mellitus and the control of cellular energy metabolism, ’ January 21–26, 2006, Vancouver, Canada

Silvia Corvera; Alison Burkart; Ja-Young Kim; Jennifer Christianson; Zhao Wang; Philipp E. Scherer

doi:10.1101/gad.1447506

Keystone meeting summary: ‘Adipogenesis, obesity, and inflammation’ and ‘Diabetes mellitus and the control of cellular energy metabolism, ’ January 21–26, 2006, Vancouver, Canada

¹Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA;
²Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA;
³Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA;
⁴Department of Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA

Abstract

The dysregulation of specific cellular functions in adipocytes, muscle cells, β cells, and the liver leads to changes in systemic metabolic processes and ultimately to the pathophysiological manifestations that cause type 2 diabetes. The underlying cellular mechanisms are complex. The two meetings summarized here aimed to highlight the recent advances in our understanding of the molecular basis of feeding and nutrient storage and on the molecular consequences of obesity in terms of promoting risk for type 2 diabetes and cardiovascular disease.

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