![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder 80309-0347, USA.
Abstract
We describe here a new gene acting downstream of let-60 ras in the vulval signaling pathway of Caenorhabditis elegans. The sur-2 (suppressor of ras) gene is defined by eight mutations identified in a genetic screen for suppressors of the Multivulva phenotype of let-60(n1046), an activated let-60 ras mutation. sur-2 mutations result in pleiotropic, incompletely penetrant phenotypes that include a Vulvaless phenotype in hermaphrodites, defects in development of the male tail, gonadal abnormalities, and larval lethality, indicating a role for the sur-2 gene product in multiple developmental events. Genetic epistasis analyses suggest that sur-2 is required late in the vulval signaling pathway, downstream of let-60 Ras, and is likely to act downstream of the Raf/MAP Kinase cascade. We cloned the sur-2 gene by DNA-mediated transformation and have shown that it encodes a novel protein. We also show that a sur-2::lacZ transgene is expressed in the vulval precursor cells at the time of vulval determination.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. L. Green, T. Inoue, and P. W. Sternberg The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway Development, November 15, 2007; 134(22): 4053 - 4062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yook and J. Hodgkin Mos1 Mutagenesis Reveals a Diversity of Mechanisms Affecting Response of Caenorhabditis elegans to the Bacterial Pathogen Microbacterium nematophilum Genetics, February 1, 2007; 175(2): 681 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Gupta, J. Liu, B. J. Hwang, N. Moghal, and P. W. Sternberg sli-3 Negatively Regulates the LET-23/Epidermal Growth Factor Receptor-Mediated Vulval Induction Pathway in Caenorhabditis elegans Genetics, November 1, 2006; 174(3): 1315 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Goldstein, D. Glossip, S. Nayak, and K. Kornfeld The CRAL/TRIO and GOLD Domain Protein CGR-1 Promotes Induction of Vulval Cell Fates in Caenorhabditis elegans and Interacts Genetically With the Ras Signaling Pathway Genetics, February 1, 2006; 172(2): 929 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Shaye and I. Greenwald LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans Development, November 15, 2005; 132(22): 5081 - 5092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Sundaram The love-hate relationship between Ras and Notch Genes & Dev., August 15, 2005; 19(16): 1825 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Berset, E. F. Hoier, and A. Hajnal The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions Genes & Dev., June 1, 2005; 19(11): 1328 - 1340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yoda, H. Kouike, H. Okano, and H. Sawa Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans Development, April 15, 2005; 132(8): 1885 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yochem, L. R. Bell, and R. K. Herman The Identities of sym-2, sym-3 and sym-4, Three Genes That Are Synthetically Lethal With mec-8 in Caenorhabditis elegans Genetics, November 1, 2004; 168(3): 1293 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Janody, Z. Martirosyan, A. Benlali, and J. E. Treisman Two subunits of the Drosophila mediator complex act together to control cell affinity Development, August 15, 2003; 130(16): 3691 - 3701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Garrett-Engele, M. L. Siegal, D. S. Manoli, B. C. Williams, H. Li, and B. S. Baker intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation Development, March 12, 2003; 129(20): 4661 - 4675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Park, J. M. Kim, L. K. Kim, S. N. Kim, J. Kim-Ha, J. H. Kim, and Y.-J. Kim Signal-Induced Transcriptional Activation by Dif Requires the dTRAP80 Mediator Module Mol. Cell. Biol., February 15, 2003; 23(4): 1358 - 1367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Moghal and P. W. Sternberg A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans Development, January 1, 2003; 130(1): 57 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Asada, Y. Choi, M. Yamada, S.-C. Wang, M.-C. Hung, J. Qin, and M. Uesugi External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator PNAS, October 1, 2002; 99(20): 12747 - 12752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Wang and A. J. Berk In Vivo Association of Adenovirus Large E1A Protein with the Human Mediator Complex in Adenovirus-Infected and -Transformed Cells J. Virol., August 12, 2002; 76(18): 9186 - 9193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Howard and M. V. Sundaram C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component Genes & Dev., July 15, 2002; 16(14): 1815 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Rocheleau, R. M. Howard, A. P. Goldman, M. L. Volk, L. J. Girard, and M. V. Sundaram A lin-45 raf Enhancer Screen Identifies eor-1, eor-2 and Unusual Alleles of Ras Pathway Genes in Caenorhabditis elegans Genetics, May 1, 2002; 161(1): 121 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang and S. W. Emmons Caenorhabditis elegans unc-37/groucho Interacts Genetically With Components of the Transcriptional Mediator Complex Genetics, February 1, 2002; 160(2): 799 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Kwon and J. Lee Biological significance of a universally conserved transcription mediator in metazoan developmental signaling pathways Development, August 15, 2001; 128(16): 3095 - 3104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Zhang and S. Emmons The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression Development, January 3, 2001; 128(5): 767 - 777. [Abstract] [PDF]
|
|
|
|
|
|
M. Boube, C. Faucher, L. Joulia, D. L. Cribbs, and H.-M. Bourbon Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification Genes & Dev., November 15, 2000; 14(22): 2906 - 2917. [Abstract] [Full Text]
|
|
|
|
|
|
L. Nilsson, T. Tiensuu, and S. Tuck Caenorhabditis elegans lin-25: A Study of Its Role in Multiple Cell Fate Specification Events Involving Ras and the Identification and Characterization of Evolutionarily Conserved Domains Genetics, November 1, 2000; 156(3): 1083 - 1096. [Abstract] [Full Text]
|
|
|
|
|
|
H. Zhang and S. W. Emmons A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene Genes & Dev., September 1, 2000; 14(17): 2161 - 2172. [Abstract] [Full Text]
|
|
|
|
|
|
M. R. Lackner and S. K. Kim Genetic Analysis of the Caenorhabditis elegans MAP Kinase Gene mpk-1 Genetics, September 1, 1998; 150(1): 103 - 117. [Abstract] [Full Text]
|
|
|
|
|
|
M. J. Gutch, A. J. Flint, J. Keller, N. K. Tonks, and M. O. Hengartner The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development Genes & Dev., February 15, 1998; 12(4): 571 - 585. [Abstract] [Full Text]
|
|
|
|
|
|
L Nilsson, X Li, T Tiensuu, R Auty, I Greenwald, and S Tuck Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates Development, January 12, 1998; 125(23): 4809 - 4819. [Abstract] [PDF]
|
|
|
|
 |
|
 J. L. Stevens, G. T. Cantin, G. Wang, A. Shevchenko, A. Shevchenko, and A. J. Berk Transcription Control by E1A and MAP Kinase Pathway via Sur2 Mediator Subunit Science, April 26, 2002; 296(5568): 755 - 758. [Abstract] [Full Text] [PDF]
|
|
