![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Imperial Cancer Research Fund Laboratories, London, UK.
Abstract
We describe a novel zinc finger protein, ZID (zinc finger protein with interaction domain). At its amino terminus ZID contains a 120-amino-acid conserved motif present in a large family of proteins that includes both the otherwise unrelated zinc finger proteins, such as Ttk, GAGA, and ZF5, and a group of poxvirus proteins: We therefore refer to this domain as the POZ (poxvirus and zinc finger) domain. The POZ domains of ZID, Ttk, and GAGA act to inhibit the interaction of their associated finger regions with DNA. This inhibitory effect is not dependent on interactions with other proteins and does not appear dependent on specific interactions between the POZ domain and the finger region. The POZ domain acts as a specific protein-protein interaction domain: The POZ domains of ZID and Ttk can interact with themselves but not with each other, POZ domains from ZF5, or the viral protein SalF17R. However, the POZ domain of GAGA can interact efficiently with the POZ domain of Ttk. In transfection experiments, the ZID POZ domain inhibits DNA binding in NIH-3T3 cells and appears to localize the protein to discrete regions of the nucleus. We discuss the implications of multimerization for the function of POZ domain proteins.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Batut, B. Schmierer, J. Cao, L. A. Raftery, C. S. Hill, and M. Howell Two highly related regulatory subunits of PP2A exert opposite effects on TGF-{beta}/Activin/Nodal signalling Development, September 1, 2008; 135(17): 2927 - 2937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Spatuzza, M. Schiavone, E. Di Salle, E. Janda, M. Sardiello, G. Fiume, O. Fierro, M. Simonetta, N. Argiriou, R. Faraonio, et al. Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk Nucleic Acids Res., August 1, 2008; 36(13): 4402 - 4416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yeasmin, K. Nakayama, M. Ishibashi, A. Katagiri, K. Iida, I. N. Purwana, N. Nakayama, and K. Miyazaki Expression of the Bric-a-Brac Tramtrack Broad Complex Protein NAC-1 in Cervical Carcinomas Seems to Correlate with Poorer Prognosis Clin. Cancer Res., March 15, 2008; 14(6): 1686 - 1691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schwendemann, T. Matkovic, C. Linke, A. Klebes, A. Hofmann, and G. Korge Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation PNAS, January 8, 2008; 105(1): 204 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhou and L. M. Riddiford rosy Function Is Required for Juvenile Hormone Effects in Drosophila melanogaster Genetics, January 1, 2008; 178(1): 273 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nakayama, N. Nakayama, T.-L. Wang, and I.-M. Shih NAC-1 Controls Cell Growth and Survival by Repressing Transcription of Gadd45GIP1, a Candidate Tumor Suppressor Cancer Res., September 1, 2007; 67(17): 8058 - 8064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gebhardt, C. Kosan, B. Herkert, T. Moroy, W. Lutz, M. Eilers, and H.-P. Elsasser Miz1 is required for hair follicle structure and hair morphogenesis J. Cell Sci., August 1, 2007; 120(15): 2586 - 2593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Froggatt, G. L. Smith, and P. M. Beard Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response J. Gen. Virol., July 1, 2007; 88(7): 1917 - 1921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-l. Gu, T. Mercher, J. W. Tyner, V. L. Goss, D. K. Walters, M. G. Cornejo, C. Reeves, L. Popova, K. Lee, M. C. Heinrich, et al. A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia Blood, July 1, 2007; 110(1): 323 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Soltani-Bejnood, S. E. Thomas, L. Villeneuve, K. Schwartz, C.-s. Hong, and B. D. McKee Role of the mod(mdg4) Common Region in Homolog Segregation in Drosophila Male Meiosis Genetics, May 1, 2007; 176(1): 161 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jiang, S. Seng, H. K. Avraham, Y. Fu, and S. Avraham Process Elongation of Oligodendrocytes Is Promoted by the Kelch-related Protein MRP2/KLHL1 J. Biol. Chem., April 20, 2007; 282(16): 12319 - 12329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakayama, N. Nakayama, B. Davidson, J. J.-C. Sheu, N. Jinawath, A. Santillan, R. Salani, R. E. Bristow, P. J. Morin, R. J. Kurman, et al. A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival PNAS, December 5, 2006; 103(49): 18739 - 18744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Ting, K. M. McGarvey, and S. B. Baylin The cancer epigenome--components and functional correlates Genes & Dev., December 1, 2006; 20(23): 3215 - 3231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rochon, P. Boyle, T. Wignes, P. R. Fobert, and C. Despres The Coactivator Function of Arabidopsis NPR1 Requires the Core of Its BTB/POZ Domain and the Oxidation of C-Terminal Cysteines PLANT CELL, December 1, 2006; 18(12): 3670 - 3685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Seng, H. K. Avraham, S. Jiang, S. Venkatesh, and S. Avraham KLHL1/MRP2 Mediates Neurite Outgrowth in a Glycogen Synthase Kinase 3{beta}-Dependent Manner Mol. Cell. Biol., November 15, 2006; 26(22): 8371 - 8384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. He, T. Zu, K. A. Benzow, H. T. Orr, H. B. Clark, and M. D. Koob Targeted Deletion of a Single Sca8 Ataxia Locus Allele in Mice Causes Abnormal Gait, Progressive Loss of Motor Coordination, and Purkinje Cell Dendritic Deficits J. Neurosci., September 27, 2006; 26(39): 9975 - 9982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Gearhart, C. M. Corcoran, J. A. Wamstad, and V. J. Bardwell Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets. Mol. Cell. Biol., September 1, 2006; 26(18): 6880 - 6889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Beard, G. C. Froggatt, and G. L. Smith Vaccinia virus kelch protein A55 is a 64 kDa intracellular factor that affects virus-induced cytopathic effect and the outcome of infection in a murine intradermal model J. Gen. Virol., June 1, 2006; 87(6): 1521 - 1529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. I. Tong, Y. Katoh, H. Kusunoki, K. Itoh, T. Tanaka, and M. Yamamoto Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model Mol. Cell. Biol., April 15, 2006; 26(8): 2887 - 2900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Thomas Analysis of Homologous Gene Clusters in Caenorhabditis elegans Reveals Striking Regional Cluster Domains Genetics, January 1, 2006; 172(1): 127 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-A. Defossez, K. F. Kelly, G. J. P. Filion, R. Perez-Torrado, F. Magdinier, H. Menoni, C. L. Nordgaard, J. M. Daniel, and E. Gilson The Human Enhancer Blocker CTC-binding Factor Interacts with the Transcription Factor Kaiso J. Biol. Chem., December 30, 2005; 280(52): 43017 - 43023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-A. Kim, S. Jiang, S. Seng, K. Cha, H. K. Avraham, and S. Avraham The BTB domain of the nuclear matrix protein NRP/B is required for neurite outgrowth J. Cell Sci., December 1, 2005; 118(23): 5537 - 5548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sasai, E. Matsuda, E. Sarashina, Y. Ishida, and M. Kawaichi Identification of a novel BTB-zinc finger transcriptional repressor, CIBZ, that interacts with CtBP corepressor Genes Cells, September 1, 2005; 10(9): 871 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-K. Lee, J.-E. Kang, H.-J. Park, M.-H. Kim, T.-H. Yim, J.-M. Kim, M.-K. Heo, K.-Y. Kim, H. J. Kwon, and M.-W. Hur FBI-1 Enhances Transcription of the Nuclear Factor-{kappa}B (NF-{kappa}B)-responsive E-selectin Gene by Nuclear Localization of the p65 Subunit of NF-{kappa}B J. Biol. Chem., July 29, 2005; 280(30): 27783 - 27791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Morinaga, A. Enomoto, Y. Shimono, F. Hirose, N. Fukuda, A. Dambara, M. Jijiwa, K. Kawai, K. Hashimoto, M. Ichihara, et al. GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region Nucleic Acids Res., July 26, 2005; 33(13): 4191 - 4201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Guidez, L. Howell, M. Isalan, M. Cebrat, R. M. Alani, S. Ivins, I. Hormaeche, M. J. McConnell, S. Pierce, P. A. Cole, et al. Histone Acetyltransferase Activity of p300 Is Required for Transcriptional Repression by the Promyelocytic Leukemia Zinc Finger Protein Mol. Cell. Biol., July 1, 2005; 25(13): 5552 - 5566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Gingerich, J. M. Gagne, D. W. Salter, H. Hellmann, M. Estelle, L. Ma, and R. D. Vierstra Cullins 3a and 3b Assemble with Members of the Broad Complex/Tramtrack/Bric-a-Brac (BTB) Protein Family to Form Essential Ubiquitin-Protein Ligases (E3s) in Arabidopsis J. Biol. Chem., May 13, 2005; 280(19): 18810 - 18821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Harris, J. Mostecki, and P. B. Rothman Repression of an Interleukin-4-responsive Promoter Requires Cooperative BCL-6 Function J. Biol. Chem., April 1, 2005; 280(13): 13114 - 13121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Figueroa, G. Gusmaroli, G. Serino, J. Habashi, L. Ma, Y. Shen, S. Feng, M. Bostick, J. Callis, H. Hellmann, et al. Arabidopsis Has Two Redundant Cullin3 Proteins That Are Essential for Embryo Development and That Interact with RBX1 and BTB Proteins to Form Multisubunit E3 Ubiquitin Ligase Complexes in Vivo PLANT CELL, April 1, 2005; 17(4): 1180 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kiefer, F. Chatail-Hermitte, P. Ravassard, E. Bayard, I. Brunet, and J. Mallet ZENON, a Novel POZ Kruppel-Like DNA Binding Protein Associated with Differentiation and/or Survival of Late Postmitotic Neurons Mol. Cell. Biol., March 1, 2005; 25(5): 1713 - 1729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gabler, M. Volkmar, S. Weinlich, A. Herbst, P. Dobberthien, S. Sklarss, L. Fanti, S. Pimpinelli, H. Kress, G. Reuter, et al. Trans-splicing of the mod(mdg4) Complex Locus Is Conserved Between the Distantly Related Species Drosophila melanogaster and D. virilis Genetics, February 1, 2005; 169(2): 723 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Weber, A. Bernhardt, M. Dieterle, P. Hano, A. Mutlu, M. Estelle, P. Genschik, and H. Hellmann Arabidopsis AtCUL3a and AtCUL3b Form Complexes with Members of the BTB/POZ-MATH Protein Family Plant Physiology, January 1, 2005; 137(1): 83 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Chen, J Zhu, G Sun, and A S Raikhel The early gene Broad is involved in the ecdysteroid hierarchy governing vitellogenesis of the mosquito Aedes aegypti J. Mol. Endocrinol., December 1, 2004; 33(3): 743 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Piazza, J. A. Costoya, T. Merghoub, R. M. Hobbs, and P. P. Pandolfi Disruption of PLZP in Mice Leads to Increased T-Lymphocyte Proliferation, Cytokine Production, and Altered Hematopoietic Stem Cell Homeostasis Mol. Cell. Biol., December 1, 2004; 24(23): 10456 - 10469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Kelly, A. A. Otchere, M. Graham, and J. M. Daniel Nuclear import of the BTB/POZ transcriptional regulator Kaiso J. Cell Sci., December 1, 2004; 117(25): 6143 - 6152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-j. Liu, L. Prazak, M. Fajardo, S. Yu, N. Tyagi, and P. E. Di Cesare Leukemia/Lymphoma-related Factor, a POZ Domain-containing Transcriptional Repressor, Interacts with Histone Deacetylase-1 and Inhibits Cartilage Oligomeric Matrix Protein Gene Expression and Chondrogenesis J. Biol. Chem., November 5, 2004; 279(45): 47081 - 47091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Fujimura, Y. Matsudo, M. Kang, Y. Takamori, T. Tokuhisa, and M. Hatano Protective role of Nd1 in doxorubicin-induced cardiotoxicity Cardiovasc Res, November 1, 2004; 64(2): 315 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kim, H.-i. Choi, H.-J. Ryu, J. H. Park, M. D. Kim, and S. Y. Kim ARIA, an Arabidopsis Arm Repeat Protein Interacting with a Transcriptional Regulator of Abscisic Acid-Responsive Gene Expression, Is a Novel Abscisic Acid Signaling Component Plant Physiology, November 1, 2004; 136(3): 3639 - 3648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Ha, J. H. Jun, H. G. Nam, and J. C. Fletcher BLADE-ON-PETIOLE1 Encodes a BTB/POZ Domain Protein Required for Leaf Morphogenesis in Arabidopsis thaliana Plant Cell Physiol., October 15, 2004; 45(10): 1361 - 1370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takamori, M. Hatano, M. Arima, A. Sakamoto, L. Fujimura, T. Hartatik, T. Kuriyama, and T. Tokuhisa BAZF is required for activation of naive CD4 T cells by TCR triggering Int. Immunol., October 1, 2004; 16(10): 1439 - 1449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pinte, N. Stankovic-Valentin, S. Deltour, B. R. Rood, C. Guerardel, and D. Leprince The Tumor Suppressor Gene HIC1 (Hypermethylated in Cancer 1) Is a Sequence-specific Transcriptional Repressor: DEFINITION OF ITS CONSENSUS BINDING SEQUENCE AND ANALYSIS OF ITS DNA BINDING AND REPRESSIVE PROPERTIES J. Biol. Chem., September 10, 2004; 279(37): 38313 - 38324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rodova, K. F. Kelly, M. VanSaun, J. M. Daniel, and M. J. Werle Regulation of the Rapsyn Promoter by Kaiso and {delta}-Catenin Mol. Cell. Biol., August 15, 2004; 24(16): 7188 - 7196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Nicolas, K. De Bosscher, B. Schmierer, and C. S. Hill Analysis of Smad nucleocytoplasmic shuttling in living cells J. Cell Sci., August 15, 2004; 117(18): 4113 - 4125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nemeth, R. Strohner, I. Grummt, and G. Langst The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo Nucleic Acids Res., August 3, 2004; 32(14): 4091 - 4099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Di Marcotullio, E. Ferretti, E. De Smaele, B. Argenti, C. Mincione, F. Zazzeroni, R. Gallo, L. Masuelli, M. Napolitano, M. Maroder, et al. RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma PNAS, July 20, 2004; 101(29): 10833 - 10838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Kelly, C. M. Spring, A. A. Otchere, and J. M. Daniel NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression J. Cell Sci., June 1, 2004; 117(13): 2675 - 2686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tashiro, A. Muto, K. Tanimoto, H. Tsuchiya, H. Suzuki, H. Hoshino, M. Yoshida, J. Walter, and K. Igarashi Repression of PML Nuclear Body-Associated Transcription by Oxidative Stress-Activated Bach2 Mol. Cell. Biol., April 15, 2004; 24(8): 3473 - 3484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Parrado, M. Robledo, M. R. Moya-Quiles, L. A. Marin, C. Chomienne, R. A. Padua, and M. R. Alvarez-Lopez The promyelocytic leukemia zinc finger protein down-regulates apoptosis and expression of the proapoptotic BID protein in lymphocytes PNAS, February 17, 2004; 101(7): 1898 - 1903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Adhikary, K. Peukert, H. Karsunky, V. Beuger, W. Lutz, H.-P. Elsasser, T. Moroy, and M. Eilers Miz1 Is Required for Early Embryonic Development during Gastrulation Mol. Cell. Biol., November 1, 2003; 23(21): 7648 - 7657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Horiuchi, E. Giniger, and T. Aigaki Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola Genes & Dev., October 15, 2003; 17(20): 2496 - 2501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lours, O. Bardot, D. Godt, F. A. Laski, and J.-L. Couderc The Drosophila melanogaster BTB proteins bric a brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif Nucleic Acids Res., September 15, 2003; 31(18): 5389 - 5398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pires de Miranda, P. C. Reading, D. C. Tscharke, B. J. Murphy, and G. L. Smith The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal model J. Gen. Virol., September 1, 2003; 84(9): 2459 - 2471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pessler and N. Hernandez Flexible DNA Binding of the BTB/POZ-domain Protein FBI-1 J. Biol. Chem., August 1, 2003; 278(31): 29327 - 29335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Salvaing, A. Lopez, A. Boivin, J. S. Deutsch, and F. Peronnet The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor Nucleic Acids Res., June 1, 2003; 31(11): 2873 - 2882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Bomont and M. Koenig Intermediate filament aggregation in fibroblasts of giant axonal neuropathy patients is aggravated in non dividing cells and by microtubule destabilization Hum. Mol. Genet., April 15, 2003; 12(8): 813 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhang, Y. Wang, J. Long, J. Girton, J. Johansen, and K. M. Johansen A Developmentally Regulated Splice Variant from the Complex lola Locus Encoding Multiple Different Zinc Finger Domain Proteins Interacts with the Chromosomal Kinase JIL-1 J. Biol. Chem., March 21, 2003; 278(13): 11696 - 11704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Couderc, D. Godt, S. Zollman, J. Chen, M. Li, S. Tiong, S. E. Cramton, I. Sahut-Barnola, and F. A. Laski The bric a brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila Development, March 7, 2003; 129(10): 2419 - 2433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
