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Research Papers
Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.
Abstract
The incorporation of histone H1 into chromatin during embryogenesis directs the specific repression of the Xenopus oocyte 5S rRNA genes. An increase in histone H1 content specifically restricts TFIIIA-activated transcription, and a decrease in histone H1 within chromatin facilitates the activation of the oocyte 5S rRNA genes by TFIIIA. Variation in the amount of histone H1 in chromatin does not significantly influence somatic 5S rRNA gene transcription. Thus, the regulated expression of histone H1 during Xenopus development has a specific and dominant role in mediating the differential expression of the oocyte and somatic 5S rRNA genes. This example demonstrates that histones can exert dominant repressive effects on the transcription of a gene in vivo in spite of an abundance of transcription factors for that gene.
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|
|
|
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|
|
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|
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|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
M Wiekowski, M Miranda, J. Nothias, and M. DePamphilis Changes in histone synthesis and modification at the beginning of mouse development correlate with the establishment of chromatin mediated repression of transcription J. Cell Sci., January 5, 1997; 110(10): 1147 - 1158. [Abstract] [PDF]
|
|
|
|
|
|
H. Clarke, M Bustin, and C Oblin Chromatin modifications during oogenesis in the mouse: removal of somatic subtypes of histone H1 from oocyte chromatin occurs post-natally through a post-transcriptional mechanism J. Cell Sci., January 2, 1997; 110(4): 477 - 487. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Freeman, H. Kurumizaka, and A. P. Wolffe Functional domains for assembly of histones H3 and H4 into the chromatin of Xenopus embryos PNAS, November 12, 1996; 93(23): 12780 - 12785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Thompson, E Legouy, E Christians, and J. Renard Progressive maturation of chromatin structure regulates HSP70.1 gene expression in the preimplantation mouse embryo Development, January 10, 1995; 121(10): 3425 - 3437. [Abstract] [PDF]
|
|
|
|
|
|
L. Zhang, S. K. Spratt, Q. Liu, B. Johnstone, H. Qi, E. E. Raschke, A. C. Jamieson, E. J. Rebar, A. P. Wolffe, and C. C. Case Synthetic Zinc Finger Transcription Factor Action at an Endogenous Chromosomal Site. ACTIVATION OF THE HUMAN ERYTHROPOIETIN GENE J. Biol. Chem., October 20, 2000; 275(43): 33850 - 33860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Carruthers and J. C. Hansen The Core Histone N Termini Function Independently of Linker Histones during Chromatin Condensation J. Biol. Chem., November 17, 2000; 275(47): 37285 - 37290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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