![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611.
The ETS domain proteins are a diverse family of transcriptional activators that have been implicated recently in the expression of a number of cell-specific and viral promoters. Nuclear respiratory factor 2 (NRF-2) is a nuclear transcription factor that activates the proximal promoter of the rat cytochrome c oxidase subunit IV (RCO4) gene through tandem sequence elements. These elements conform to the consensus for high-affinity ETS domain recognition sites. We have now purified NRF-2 to homogeneity from HeLa cells and find that it consists of five polypeptides, only one of which has intrinsic DNA-binding ability. The others participate in the formation of heteromeric complexes with distinct binding properties. NRF-2 also specifically recognizes multiple binding sites in the mouse cytochrome c oxidase subunit Vb (MCO5b) gene. As in the functionally related RCO4 gene, tandemly arranged NRF-2 sites are essential for the activity of the proximal MCO5b promoter, further substantiating a role for NRF-2 in respiratory chain expression. Determination of peptide sequences from the various subunits of HeLa NRF-2 reveals a high degree of sequence identity with mouse GA-binding protein (GABP), a multisubunit ETS domain activator of herpes simplex virus immediate early genes. A cellular role in the activation of nuclear genes specifying mitochondrial respiratory function is thus assigned to an ETS domain activator of viral promoters.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  F. S. Jones, J. Jing, A. H. Stonehouse, A. Stevens, and G. M. Edelman Caffeine Stimulates Cytochrome Oxidase Expression and Activity in the Striatum in a Sexually Dimorphic Manner Mol. Pharmacol., September 1, 2008; 74(3): 673 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Lehman, S. Boudina, N. H. Banke, N. Sambandam, X. Han, D. M. Young, T. C. Leone, R. W. Gross, E. D. Lewandowski, E. D. Abel, et al. The transcriptional coactivator PGC-1{alpha} is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H185 - H196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Vercauteren, N. Gleyzer, and R. C. Scarpulla PGC-1-related Coactivator Complexes with HCF-1 and NRF-2{beta} in Mediating NRF-2(GABP)-dependent Respiratory Gene Expression J. Biol. Chem., May 2, 2008; 283(18): 12102 - 12111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Scarpulla Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function Physiol Rev, April 1, 2008; 88(2): 611 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Crook, M. Olive, H.-H. Xue, T. H. Langenickel, M. Boehm, W. J. Leonard, and E. G. Nabel GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression FASEB J, January 1, 2008; 22(1): 225 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jaworski, C. L. Smith, and S. J. Burden GA-Binding Protein Is Dispensable for Neuromuscular Synapse Formation and Synapse-Specific Gene Expression Mol. Cell. Biol., July 1, 2007; 27(13): 5040 - 5046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Wright, P. C. Geiger, D.-H. Han, T. E. Jones, and J. O. Holloszy Calcium Induces Increases in Peroxisome Proliferator-activated Receptor {gamma} Coactivator-1{alpha} and Mitochondrial Biogenesis by a Pathway Leading to p38 Mitogen-activated Protein Kinase Activation J. Biol. Chem., June 29, 2007; 282(26): 18793 - 18799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Vercauteren, R. A. Pasko, N. Gleyzer, V. M. Marino, and R. C. Scarpulla PGC-1-Related Coactivator: Immediate Early Expression and Characterization of a CREB/NRF-1 Binding Domain Associated with Cytochrome c Promoter Occupancy and Respiratory Growth Mol. Cell. Biol., October 15, 2006; 26(20): 7409 - 7419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Angus, J. V. Chakkalakal, A. Mejat, J. K. Eibl, G. Belanger, L. A. Megeney, E. R. Chin, L. Schaeffer, R. N. Michel, and B. J. Jasmin Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction Am J Physiol Cell Physiol, October 1, 2005; 289(4): C908 - C917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Boopathi, N. Lenka, S. K. Prabu, J.-K. Fang, F. Wilkinson, M. Atchison, A. Giallongo, and N. G. Avadhani Regulation of Murine Cytochrome c Oxidase Vb Gene Expression during Myogenesis: YY-1 AND HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D-LIKE PROTEIN (JKTBP1) RECIPROCALLY REGULATE TRANSCRIPTION ACTIVITY BY PHYSICAL INTERACTION WITH THE BERF-1/ZBP-89 FACTOR J. Biol. Chem., August 20, 2004; 279(34): 35242 - 35254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ristevski, D. A. O'Leary, A. P. Thornell, M. J. Owen, I. Kola, and P. J. Hertzog The ETS Transcription Factor GABP{alpha} Is Essential for Early Embryogenesis Mol. Cell. Biol., July 1, 2004; 24(13): 5844 - 5849. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Kelly and R. C. Scarpulla Transcriptional regulatory circuits controlling mitochondrial biogenesis and function Genes & Dev., February 15, 2004; 18(4): 357 - 368. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Imaki, K. Nakayama, S. Delehouzee, H. Handa, M. Kitagawa, T. Kamura, and K. I. Nakayama Cell Cycle-dependent Regulation of the Skp2 Promoter by GA-binding Protein Cancer Res., August 1, 2003; 63(15): 4607 - 4613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. de Jesus, P. R. Smith, L. C. Spender, C. Elgueta Karstegl, H. H. Niller, D. Huang, and P. J. Farrell Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV J. Gen. Virol., June 1, 2003; 84(6): 1443 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Puigserver and B. M. Spiegelman Peroxisome Proliferator-Activated Receptor-{gamma} Coactivator 1{alpha} (PGC-1{alpha}): Transcriptional Coactivator and Metabolic Regulator Endocr. Rev., February 1, 2003; 24(1): 78 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sawa, T. Yoshikawa, F. Matsuda-Suzuki, S. Delehouzee, M. Goto, H. Watanabe, J.-i. Sawada, K. Kataoka, and H. Handa YEAF1/RYBP and YAF-2 Are Functionally Distinct Members of a Cofactor Family for the YY1 and E4TF1/hGABP Transcription Factors J. Biol. Chem., June 14, 2002; 277(25): 22484 - 22490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanaka, A. Ueda, H. Kanamori, H. Ideguchi, J. Yang, S. Kitajima, and Y. Ishigatsubo Cell-cycle-dependent Regulation of Human aurora A Transcription Is Mediated by Periodic Repression of E4TF1 J. Biol. Chem., March 15, 2002; 277(12): 10719 - 10726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Vinante, A. Rigo, M. T. Scupoli, and G. Pizzolo CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 Blood, January 1, 2002; 99(1): 52 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Solecki, G. Bernhardt, M. Lipp, and E. Wimmer Identification of a Nuclear Respiratory Factor-1 Binding Site within the Core Promoter of the human polio virus receptor/CD155 Gene J. Biol. Chem., April 21, 2000; 275(17): 12453 - 12462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chinenov, M. Henzl, and M. E. Martin The alpha and beta Subunits of the GA-binding Protein Form a Stable Heterodimer in Solution. REVISED MODEL OF HETEROTETRAMERIC COMPLEX ASSEMBLY J. Biol. Chem., March 10, 2000; 275(11): 7749 - 7756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. I. Aizencang, D. F. Bishop, D. Forrest, K. H. Astrin, and R. J. Desnick Uroporphyrinogen III Synthase. AN ALTERNATIVE PROMOTER CONTROLS ERYTHROID-SPECIFIC EXPRESSION IN THE MURINE GENE J. Biol. Chem., January 28, 2000; 275(4): 2295 - 2304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-i. Sawada, N. Simizu, F. Suzuki, C. Sawa, M. Goto, M. Hasegawa, T. Imai, H. Watanabe, and H. Handa Synergistic Transcriptional Activation by hGABP and Select Members of the Activation Transcription Factor/cAMP Response Element-binding Protein Family J. Biol. Chem., December 10, 1999; 274(50): 35475 - 35482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Hughes, M. M.-Y. Chi, O. H. Lowry, and K. Gundersen Myogenin Induces a Shift of Enzyme Activity from Glycolytic to Oxidative Metabolism in Muscles of Transgenic Mice J. Cell Biol., May 3, 1999; 145(3): 633 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Barath, B. Albert-Fournier, K. Luciakova, and B. D. Nelson Characterization of a Silencer Element and Purification of a Silencer Protein That Negatively Regulates the Human Adenine Nucleotide Translocator 2 Promoter J. Biol. Chem., February 5, 1999; 274(6): 3378 - 3384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Suzuki, M. Goto, C. Sawa, S. Ito, H. Watanabe, J.-i. Sawada, and H. Handa Functional Interactions of Transcription Factor Human GA-binding Protein Subunits J. Biol. Chem., November 6, 1998; 273(45): 29302 - 29308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sugimoto, S. Odani, and S. Yamashita Cloning and Expression of cDNA Encoding Rat Liver 60-kDa Lysophospholipase Containing an Asparaginase-like Region and Ankyrin Repeat J. Biol. Chem., May 15, 1998; 273(20): 12536 - 12542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pan, L. Xia, and R. P. McEver Comparison of Promoters for the Murine and Human P-selectin Genes Suggests Species-specific and Conserved Mechanisms for Transcriptional Regulation in Endothelial Cells J. Biol. Chem., April 17, 1998; 273(16): 10058 - 10067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chinenov, T. Schmidt, X.-Y. Yang, and M. E. Martin Identification of Redox-sensitive Cysteines in GA-binding Protein-alpha That Regulate DNA Binding and Heterodimerization J. Biol. Chem., March 13, 1998; 273(11): 6203 - 6209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Batchelor, D. E. Piper, F. C. de la Brousse, S. L. McKnight, and C. Wolberger The Structure of GABP  / : An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNAScience, February 13, 1998; 279(5353): 1037 - 1041. [Abstract] [Full Text]
|
|
|
|
|
|
M. Yu, X.-Y. Yang, T. Schmidt, Y. Chinenov, R. Wang, and M. E. Martin GA-binding Protein-dependent Transcription Initiator Elements. EFFECT OF HELICAL SPACING BETWEEN POLYOMAVIRUS ENHANCER A FACTOR 3(PEA3)/Ets-BINDING SITES ON INITIATOR ACTIVITY J. Biol. Chem., November 14, 1997; 272(46): 29060 - 29067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kamura, H. Handa, N. Hamasaki, and S. Kitajima Characterization of the Human Thrombopoietin Gene Promoter. A POSSIBLE ROLE OF AN Ets TRANSCRIPTION FACTOR, E4TF1/GABP J. Biol. Chem., April 25, 1997; 272(17): 11361 - 11368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A.M. Breen and E. M. Jordan Regulation of the Nuclear Gene That Encodes the alpha -Subunit of the Mitochondrial F0F1-ATP Synthase Complex. ACTIVATION BY UPSTREAM STIMULATORY FACTOR 2 J. Biol. Chem., April 18, 1997; 272(16): 10538 - 10542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Seelan and L. I. Grossman Structural Organization and Promoter Analysis of the Bovine Cytochrome c Oxidase Subunit VIIc Gene. A FUNCTIONAL ROLE FOR YY1 J. Biol. Chem., April 11, 1997; 272(15): 10175 - 10181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Basu, N. Lenka, J. Mullick, and N. G. Avadhani Regulation of Murine Cytochrome Oxidase Vb Gene Expression in Different Tissues and during Myogenesis. ROLE OF A YY-1 FACTOR-BINDING NEGATIVE ENHANCER J. Biol. Chem., February 28, 1997; 272(9): 5899 - 5908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Lenka, A. Basu, J. Mullick, and N. G. Avadhani The Role of an E Box Binding Basic Helix Loop Helix Protein in the Cardiac Muscle-specific Expression of the Rat Cytochrome Oxidase Subunit VIII Gene J. Biol. Chem., November 22, 1996; 271(47): 30281 - 30289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Martin, Y. Chinenov, M. Yu, T. K. Schmidt, and X.-Y. Yang Redox Regulation of GA-binding Protein-alpha DNA Binding Activity J. Biol. Chem., October 11, 1996; 271(41): 25617 - 25623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Li, Z. Hodny, K. Luciakova, P. Barath, and B. D. Nelson Sp1 Activates and Inhibits Transcription from Separate Elements in the Proximal Promoter of the Human Adenine Nucleotide Translocase 2(ANT2) Gene J. Biol. Chem., August 2, 1996; 271(31): 18925 - 18930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Markiewicz, R. Bosselut, F. L. Deist, J.-P. d. Villartay, C. Hivroz, J. Ghysdael, A. Fischer, and G. d. S. Basile Tissue-specific Activity of the gamma c Chain Gene Promoter Depends upon an Ets Binding Site and Is Regulated by GA-binding Protein J. Biol. Chem., June 21, 1996; 271(25): 14849 - 14855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F C de la Brousse, E H Birkenmeier, D S King, L B Rowe, and S L McKnight Molecular and genetic characterization of GABP beta. Genes & Dev., August 1, 1994; 8(15): 1853 - 1865. [Abstract] [PDF]
|
|
|
|
|
|
C A Virbasius, J V Virbasius, and R C Scarpulla NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes & Dev., December 1, 1993; 7(12a): 2431 - 2445. [Abstract] [PDF]
|
|
|
|
|
|
Q. Gong, L. J. Brown, and M. J. MacDonald Functional Analysis of Two Promoters for the Human Mitochondrial Glycerol Phosphate Dehydrogenase Gene J. Biol. Chem., November 22, 2000; 275(48): 38012 - 38021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Moore, G.-L. Wang, N. S. Belaguli, R. J. Schwartz, and J. B. McMillin GATA-4 and Serum Response Factor Regulate Transcription of the Muscle-specific Carnitine Palmitoyltransferase I beta in Rat Heart J. Biol. Chem., January 5, 2001; 276(2): 1026 - 1033. [Abstract] [Full Text] [PDF]
|
|
