![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Division of Basic Science Research, Children's Hospital Research Foundation, Cincinnati, Ohio 45229.
Abstract
Hox A11 is one of the expanded set of vertebrate homeo box (Hox) genes with similarities to the Drosophila homeotic gene, Abdominal-B (Abd-B). These Abd-B-type Hox genes have been shown to be expressed in the most caudal regions of the developing vertebrate embryo and in overlapping domains within the developing limbs, suggesting that these genes play important roles in pattern formation in both appendicular and axial regions of the body. In this report whole-mount in situ hybridization in mouse embryos gave a precise description of Hox A11 gene expression in the developing limbs and in the axial domain of the developing body. In addition, we generated a targeted mutation in Hox A11 and characterized the resulting phenotype to begin to dissect developmental functions of the Abd-B subfamily of Hox genes. Hox A11 mutant mice exhibited double homeotic transformations, with the thirteenth thoracic segment posteriorized to form an additional first lumbar vertebra and with the sacral region anteriorized, generating yet another lumbar segment. Furthermore, skeletal malformations were observed in both forelimbs and hindlimbs. In mutant forelimbs, the ulna and radius were misshapen, the pisiform and triangular carpal bones were fused, and abnormal sesamoid bone development occurred. In mutant hindlimbs the tibia and fibula were joined incorrectly and malformed at their distal ends. Also, an enlarged sesamoid developed ventral to the tibiale bone. Both heterozygous and homozygous mice displayed mutant phenotypes adding an additional level of complexity to the Hox code hypothesis.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. P.-s. Luke, G. Sui, H. Liu, and Y. Shi Yin Yang 1 Physically Interacts with Hoxa11 and Represses Hoxa11-dependent Transcription J. Biol. Chem., November 3, 2006; 281(44): 33226 - 33232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Dlugaszewska, A Silahtaroglu, C Menzel, S Kubart, M Cohen, S Mundlos, Z Tumer, K Kjaer, U Friedrich, H-H Ropers, et al. Breakpoints around the HOXD cluster result in various limb malformations J. Med. Genet., February 1, 2006; 43(2): 111 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. Sampogna and S. K. Nigam Implications of Gene Networks for Understanding Resilience and Vulnerability in the Kidney Branching Program Physiology, December 1, 2004; 19(6): 339 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. M. Simmen, R. R. Eason, J. R. McQuown, A. L. Linz, T.-J. Kang, L. Chatman Jr., S. R. Till, Y. Fujii-Kuriyama, F. A. Simmen, and S. P. Oh Subfertility, Uterine Hypoplasia, and Partial Progesterone Resistance in Mice Lacking the Kruppel-like Factor 9/Basic Transcription Element-binding Protein-1 (Bteb1) Gene J. Biol. Chem., July 9, 2004; 279(28): 29286 - 29294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Shah, R. V. Sampogna, H. Sakurai, K. T. Bush, and S. K. Nigam Branching morphogenesis and kidney disease Development, April 1, 2004; 131(7): 1449 - 1462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Boulet and M. R. Capecchi Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod Development, January 15, 2004; 131(2): 299 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Akbas and H. S. Taylor HOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs Biol Reprod, January 1, 2004; 70(1): 39 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Wellik, P. J. Hawkes, and M. R. Capecchi Hox11 paralogous genes are essential for metanephric kidney induction Genes & Dev., June 1, 2002; 16(11): 1423 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhao and S. S. Potter Functional specificity of the Hoxa13 homeobox Development, August 15, 2001; 128(16): 3197 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M del Mar Lorente, C Marcos-Gutierrez, C Perez, J Schoorlemmer, A Ramirez, T Magin, and M Vidal Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice Development, January 12, 2000; 127(23): 5093 - 5100. [Abstract] [PDF]
|
|
|
|
 |
|
 C. O. Lovejoy, M. J. Cohn, and T. D. White Morphological analysis of the mammalian postcranium: A developmental perspective PNAS, November 9, 1999; 96(23): 13247 - 13252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Taylor, P. Igarashi, D. L. Olive, and A. Arici Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium J. Clin. Endocrinol. Metab., March 1, 1999; 84(3): 1129 - 1135. [Abstract] [Full Text]
|
|
|
|
|
|
K Hashimoto, Y Yokouchi, M Yamamoto, and A Kuroiwa Distinct signaling molecules control Hoxa-11 and Hoxa-13 expression in the muscle precursor and mesenchyme of the chick limb bud Development, January 6, 1999; 126(12): 2771 - 2783. [Abstract] [PDF]
|
|
|
|
|
|
A Zuniga and R Zeller Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity Development, January 1, 1999; 126(1): 13 - 21. [Abstract] [PDF]
|
|
|
|
|
|
Y Herault, J Beckers, T Kondo, N Fraudeau, and D Duboule Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex Development, January 5, 1998; 125(9): 1669 - 1677. [Abstract] [PDF]
|
|
|
|
|
|
W Wang, T Van De Water, and T Lufkin Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene Development, January 2, 1998; 125(4): 621 - 634. [Abstract] [PDF]
|
|
|
|
|
|
J. Zakany, C. Fromental-Ramain, X. Warot, and D. Duboule Regulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implications PNAS, December 9, 1997; 94(25): 13695 - 13700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Lawrence, C. D. Helgason, G. Sauvageau, S. Fong, D. J. Izon, R. K. Humphries, and C. Largman Mice Bearing a Targeted Interruption of the Homeobox Gene HOXA9 Have Defects in Myeloid, Erythroid, and Lymphoid Hematopoiesis Blood, March 15, 1997; 89(6): 1922 - 1930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Carpenter, J. Goddard, A. Davis, T. Nguyen, and M. Capecchi Targeted disruption of Hoxd-10 affects mouse hindlimb development Development, January 11, 1997; 124(22): 4505 - 4514. [Abstract] [PDF]
|
|
|
|
|
|
V Knezevic, R De Santo, K Schughart, U Huffstadt, C Chiang, K. Mahon, and S Mackem Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop Development, January 11, 1997; 124(22): 4523 - 4536. [Abstract] [PDF]
|
|
|
|
|
|
C. Peichel, B Prabhakaran, and T. Vogt The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning Development, January 9, 1997; 124(18): 3481 - 3492. [Abstract] [PDF]
|
|
|
|
|
|
Y Herault, N Fraudeau, J Zakany, and D Duboule Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes Development, January 9, 1997; 124(18): 3493 - 3500. [Abstract] [PDF]
|
|
|
|
|
|
M Gerard, J Y Chen, H Gronemeyer, P Chambon, D Duboule, and J Zakany In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. Genes & Dev., September 15, 1996; 10(18): 2326 - 2334. [Abstract] [PDF]
|
|
|
|
|
|
J. Barrow and M. Capecchi Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4 Development, January 12, 1996; 122(12): 3817 - 3828. [Abstract] [PDF]
|
|
|
|
|
|
C Fromental-Ramain, X Warot, N Messadecq, M LeMeur, P Dolle, and P Chambon Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod Development, January 10, 1996; 122(10): 2997 - 3011. [Abstract] [PDF]
|
|
|
|
|
|
J. Goddard, M Rossel, N. Manley, and M. Capecchi Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve Development, January 10, 1996; 122(10): 3217 - 3228. [Abstract] [PDF]
|
|
|
|
|
|
C. Nelson, B. Morgan, A. Burke, E Laufer, E DiMambro, L. Murtaugh, E Gonzales, L Tessarollo, L. Parada, and C Tabin Analysis of Hox gene expression in the chick limb bud Development, January 5, 1996; 122(5): 1449 - 1466. [Abstract] [PDF]
|
|
|
|
|
|
A. Davis and M. Capecchi A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse Development, January 4, 1996; 122(4): 1175 - 1185. [Abstract] [PDF]
|
|
|
|
|
|
B Favier, F. Rijli, C Fromental-Ramain, V Fraulob, P Chambon, and P Dolle Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton Development, January 2, 1996; 122(2): 449 - 460. [Abstract] [PDF]
|
|
|
|
|
|
C Fromental-Ramain, X Warot, S Lakkaraju, B Favier, H Haack, C Birling, A Dierich, P Doll e, and P Chambon Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning Development, January 2, 1996; 122(2): 461 - 472. [Abstract] [PDF]
|
|
|
|
|
|
Y Yokouchi, S Nakazato, M Yamamoto, Y Goto, T Kameda, H Iba, and A Kuroiwa Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes & Dev., October 15, 1995; 9(20): 2509 - 2522. [Abstract] [PDF]
|
|
|
|
|
|
J F Martin, A Bradley, and E N Olson The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes & Dev., May 15, 1995; 9(10): 1237 - 1249. [Abstract] [PDF]
|
|
|
|
|
|
D. Gardiner, B Blumberg, Y Komine, and S. Bryant Regulation of HoxA expression in developing and regenerating axolotl limbs Development, January 6, 1995; 121(6): 1731 - 1741. [Abstract] [PDF]
|
|
|
|
|
|
H. Hsieh-Li, D. Witte, M Weinstein, W Branford, H Li, K Small, and S. Potter Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility Development, January 5, 1995; 121(5): 1373 - 1385. [Abstract] [PDF]
|
|
|
|
|
|
A. Burke, C. Nelson, B. Morgan, and C Tabin Hox genes and the evolution of vertebrate axial morphology Development, January 2, 1995; 121(2): 333 - 346. [Abstract] [PDF]
|
|
|
|
|
|
D E Rancourt, T Tsuzuki, and M R Capecchi Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes & Dev., January 1, 1995; 9(1): 108 - 122. [Abstract] [PDF]
|
|
|
|
 |
|
 D Duboule How to make a limb? Science, October 28, 1994; 266(5185): 575 - 576. [PDF]
|
|
|
|
|
|
A. Davis and M. Capecchi Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11 Development, January 8, 1994; 120(8): 2187 - 2198. [Abstract] [PDF]
|
|
