![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Division of Basic Sciences A2-025, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Abstract
Mad is a basic-helix-loop-helix-zipper protein that heterodimerizes with Max in vitro. Mad:Max heterodimers recognize the same E-box-related DNA-binding sites as Myc:Max heterodimers. However, in transient transfection assays Myc and Mad influence transcription in opposite ways through interaction with Max; Myc activates while Mad represses transcription. Here, we demonstrate that Mad protein is induced rapidly upon differentiation of cells of the myeloid lineage. The Mad protein is synthesized in human cells as a 35-kD nuclear phosphoprotein with an extremely short half-life (t1/2 = 15-30 min) and can be detected in vivo in a complex with Max. In the undifferentiated U937 monocyte cell line Max was found complexed with Myc but not Mad. However, Mad:Max complexes began to accumulate as early as 2 hr after induction of macrophage differentiation with TPA. By 48 hr following TPA treatment only Mad:Max complexes were detectable. These data show that differentiation is accompanied by a change in the composition of Max heterocomplexes. We speculate that this switch in heterocomplexes results in a change in the transcriptional regulation of Myc:Max target genes required for cell proliferation.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  P. G. Fuhrken, C. Chen, P. A. Apostolidis, M. Wang, W. M. Miller, and E. T. Papoutsakis Gene Ontology-driven transcriptional analysis of CD34+ cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis Physiol Genomics, April 21, 2008; 33(2): 159 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Jiang, N. Hein, K. Eckert, J. Luscher-Firzlaff, and B. Luscher Regulation of the MAD1 promoter by G-CSF Nucleic Acids Res., March 1, 2008; 36(5): 1517 - 1531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhang, F. Li, X. Liu, L. Shen, J. Liu, J. Su, W. Zhang, Y. Deng, L. Wang, N. Liu, et al. The Repression of Human Differentiation-related Gene NDRG2 Expression by Myc via Miz-1-dependent Interaction with the NDRG2 Core Promoter J. Biol. Chem., December 22, 2006; 281(51): 39159 - 39168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Hooker and P. J. Hurlin Of Myc and Mnt J. Cell Sci., January 15, 2006; 119(2): 208 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Sheppard, T. Doedt, L. Y. Chiang, H. S. Kim, D. Chen, W. C. Nierman, and S. G. Filler The Aspergillus fumigatus StuA Protein Governs the Up-Regulation of a Discrete Transcriptional Program during the Acquisition of Developmental Competence Mol. Biol. Cell, December 1, 2005; 16(12): 5866 - 5879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hultquist, C. Cetinkaya, S. Wu, A. Castell, A. Erlandsson, and L.-G. Larsson Mad 1 Inhibits Cell Growth and Proliferation but Does Not Promote Differentiation or Overall Survival in Human U-937 Monoblasts Mol. Cancer Res., August 1, 2004; 2(8): 464 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Le Guezennec, G. Vriend, and H. G. Stunnenberg Molecular Determinants of the Interaction of Mad with the PAH2 Domain of mSin3 J. Biol. Chem., June 11, 2004; 279(24): 25823 - 25829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Grinberg, C.-D. Hu, and T. K. Kerppola Visualization of Myc/Max/Mad Family Dimers and the Competition for Dimerization in Living Cells Mol. Cell. Biol., May 15, 2004; 24(10): 4294 - 4308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Cowley, R. S. Kang, J. V. Frangioni, J. J. Yada, A. M. DeGrand, I. Radhakrishnan, and R. N. Eisenman Functional Analysis of the Mad1-mSin3A Repressor-Corepressor Interaction Reveals Determinants of Specificity, Affinity, and Transcriptional Response Mol. Cell. Biol., April 1, 2004; 24(7): 2698 - 2709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Nilsson, K. H. Maclean, U. B. Keller, H. Pendeville, T. A. Baudino, and J. L. Cleveland Mnt Loss Triggers Myc Transcription Targets, Proliferation, Apoptosis, and Transformation Mol. Cell. Biol., February 15, 2004; 24(4): 1560 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume Interferon-{gamma}: an overview of signals, mechanisms and functions J. Leukoc. Biol., February 1, 2004; 75(2): 163 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Hadsell, S. Bonnette, J. George, D. Torres, Y. Klementidis, S. Gao, P. M. Haney, J. Summy-Long, M. S. Soloff, A. F. Parlow, et al. Diminished Milk Synthesis in Upstream Stimulatory Factor 2 Null Mice Is Associated With Decreased Circulating Oxytocin and Decreased Mammary Gland Expression of Eukaryotic Initiation Factors 4E and 4G Mol. Endocrinol., November 1, 2003; 17(11): 2251 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bowen, A. Lapham, E. Phillips, I. Yeung, M. Alter-Koltunoff, B.-Z. Levi, V. H. Perry, D. A. Mann, and C. H. Barton Characterization of the Murine Nramp1 Promoter: REQUIREMENTS FOR TRANSACTIVATION BY Miz-1 J. Biol. Chem., September 19, 2003; 278(38): 36017 - 36026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sarkar, M. Leszczyniecka, D.-c. Kang, I. V. Lebedeva, K. Valerie, S. Dhar, T. K. Pandita, and P. B. Fisher Down-regulation of Myc as a Potential Target for Growth Arrest Induced by Human Polynucleotide Phosphorylase (hPNPaseold-35) in Human Melanoma Cells J. Biol. Chem., June 27, 2003; 278(27): 24542 - 24551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Chaffin, R. S. Brogan, R. L. Stouffer, and C. A. VandeVoort Dynamics of Myc/Max/Mad Expression during Luteinization of Primate Granulosa Cells in Vitro: Association with Periovulatory Proliferation Endocrinology, April 1, 2003; 144(4): 1249 - 1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Nikiforov, N. Popov, I. Kotenko, M. Henriksson, and M. D. Cole The Mad and Myc Basic Domains Are Functionally Equivalent J. Biol. Chem., March 21, 2003; 278(13): 11094 - 11099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Kenney, M. D. Cole, and D. H. Rowitch Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors Development, January 1, 2003; 130(1): 15 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Eilers, E. Sundwall, M. Lin, A. A. Sullivan, and D. E. Ayer A Novel Heterodimerization Domain, CRM1, and 14-3-3 Control Subcellular Localization of the MondoA-Mlx Heterocomplex Mol. Cell. Biol., December 15, 2002; 22(24): 8514 - 8526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. M. Mu, X. Y. Yin, and E. V. Prochownik Pag, a Putative Tumor Suppressor, Interacts with the Myc Box II Domain of c-Myc and Selectively Alters Its Biological Function and Target Gene Expression J. Biol. Chem., November 1, 2002; 277(45): 43175 - 43184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang and C. Jones The Bovine Herpesvirus 1 Immediate-Early Protein (bICP0) Associates with Histone Deacetylase 1 To Activate Transcription J. Virol., October 15, 2001; 75(20): 9571 - 9578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Eisenman Deconstructing Myc Genes & Dev., August 15, 2001; 15(16): 2023 - 2030. [Full Text] [PDF]
|
|
|
|
|
|
C. Bouchard, O. Dittrich, A. Kiermaier, K. Dohmann, A. Menkel, M. Eilers, and B. Luscher Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter Genes & Dev., August 15, 2001; 15(16): 2042 - 2047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Frank, M. Schroeder, P. Fernandez, S. Taubert, and B. Amati Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation Genes & Dev., August 15, 2001; 15(16): 2069 - 2082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Soriani, N. A. Williams, and T. R. Hirst Escherichia coli Enterotoxin B Subunit Triggers Apoptosis of CD8+ T Cells by Activating Transcription Factor c-Myc Infect. Immun., August 1, 2001; 69(8): 4923 - 4930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Baudino and J. L. Cleveland The Max Network Gone Mad Mol. Cell. Biol., February 1, 2001; 21(3): 691 - 702. [Full Text]
|
|
|
|
|
|
C. Quéva, G. A. McArthur, B. M. Iritani, and R. N. Eisenman Targeted Deletion of the S-Phase-Specific Myc Antagonist Mad3 Sensitizes Neuronal and Lymphoid Cells to Radiation-Induced Apoptosis Mol. Cell. Biol., February 1, 2001; 21(3): 703 - 712. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Hasegawa, M. Yasukawa, I. Sakai, and S. Fujita Transcriptional Down-Regulation of CXC Chemokine Receptor 4 Induced by Impaired Association of Transcription Regulator YY1 with c-Myc in Human Herpesvirus 6-Infected Cells J. Immunol., January 15, 2001; 166(2): 1125 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Billin, A. L. Eilers, K. L. Coulter, J. S. Logan, and D. E. Ayer MondoA, a Novel Basic Helix-Loop-Helix-Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network Mol. Cell. Biol., December 1, 2000; 20(23): 8845 - 8854. [Abstract] [Full Text]
|
|
|
|
|
|
A. N. Billin, H. Thirlwell, and D. E. Ayer beta -Catenin-Histone Deacetylase Interactions Regulate the Transition of LEF1 from a Transcriptional Repressor to an Activator Mol. Cell. Biol., September 15, 2000; 20(18): 6882 - 6890. [Abstract] [Full Text]
|
|
|
|
|
|
G. Barrera-Hernandez, C. M. Cultraro, S. Pianetti, and S. Segal Mad1 Function Is Regulated through Elements within the Carboxy Terminus Mol. Cell. Biol., June 15, 2000; 20(12): 4253 - 4264. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. Günes, S. Lichtsteiner, A. P. Vasserot, and C. Englert Expression of the hTERT Gene Is Regulated at the Level of Transcriptional Initiation and Repressed by Mad1 Cancer Res., April 1, 2000; 60(8): 2116 - 2121. [Abstract] [Full Text]
|
|
|
|
|
|
A. N. Billin, A. L. Eilers, C. Queva, and D. E. Ayer Mlx, a Novel Max-like BHLHZip Protein That Interacts with the Max Network of Transcription Factors J. Biol. Chem., December 17, 1999; 274(51): 36344 - 36350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Quéva, G. A. McArthur, L. S. Ramos, and R. N. Eisenman Dwarfism and Dysregulated Proliferation in Mice Overexpressing the MYC Antagonist MAD1 Cell Growth Differ., December 1, 1999; 10(12): 785 - 796. [Abstract] [Full Text]
|
|
|
|
|
|
J. M. Grad, J. Le Dai, S. Wu, and K. L. Burnstein Multiple Androgen Response Elements and a Myc Consensus Site in the Androgen Receptor (AR) Coding Region Are Involved in Androgen-Mediated Up-Regulation of AR Messenger RNA Mol. Endocrinol., November 1, 1999; 13(11): 1896 - 1911. [Abstract] [Full Text]
|
|
|
|
|
|
D. Vermaak, P. A. Wade, P. L. Jones, Y.-B. Shi, and A. P. Wolffe Functional Analysis of the SIN3-Histone Deacetylase RPD3-RbAp48-Histone H4 Connection in the Xenopus Oocyte Mol. Cell. Biol., September 1, 1999; 19(9): 5847 - 5860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lerga, P. Crespo, M. Berciano, M. D. Delgado, M. Cañelles, C. Calés, C. Richard, E. Ceballos, P. Gutierrez, N. Ajenjo, et al. Regulation of c-Myc and Max in Megakaryocytic and Monocytic-Macrophagic Differentiation of K562 Cells Induced by Protein Kinase C Modifiers: c-Myc Is Down-Regulated but Does Not Inhibit Differentiation Cell Growth Differ., September 1, 1999; 10(9): 639 - 654. [Abstract] [Full Text]
|
|
|
|
|
|
P. Sridhar, Y. Liu, L. D. Chin, C. E. Borja, M. Mann, H. A. Skopicki, and R. R. Freter Platelet-Derived Growth Factor-Stimulated Expression of the MCP-1 Immediate-Early Gene Involves an Inhibitory Multiprotein Complex Mol. Cell. Biol., June 1, 1999; 19(6): 4219 - 4230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Bahram, S. Wu, F. Oberg, B. Luscher, and L.-G. Larsson Posttranslational Regulation of Myc Function in Response to Phorbol Ester/Interferon-gamma -Induced Differentiation of v-Myc-Transformed U-937 Monoblasts Blood, June 1, 1999; 93(11): 3900 - 3912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Moriuchi, H. Moriuchi, D. M. Margolis, and A. S. Fauci USF/c-Myc Enhances, While Yin-Yang 1 Suppresses, the Promoter Activity of CXCR4, a Coreceptor for HIV-1 Entry J. Immunol., May 15, 1999; 162(10): 5986 - 5992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Gradin, R. Toftgard, L. Poellinger, and A. Berghard Repression of Dioxin Signal Transduction in Fibroblasts. IDENTIFICATION OF A PUTATIVE REPRESSOR ASSOCIATED WITH Arnt J. Biol. Chem., May 7, 1999; 274(19): 13511 - 13518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tokitou, T. Nomura, M. M. Khan, S. C. Kaul, R. Wadhwa, T. Yasukawa, I. Kohno, and S. Ishii Viral Ski Inhibits Retinoblastoma Protein (Rb)-mediated Transcriptional Repression in a Dominant Negative Fashion J. Biol. Chem., February 19, 1999; 274(8): 4485 - 4488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nomura, M. M. Khan, S. C. Kaul, H.-D. Dong, R. Wadhwa, C. Colmenares, I. Kohno, and S. Ishii Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor Genes & Dev., February 15, 1999; 13(4): 412 - 423. [Abstract] [Full Text]
|
|
|
|
|
|
X. Wang, M. A. Peters, F. E. Utama, Y. Wang, and E. J. Taparowsky The Adrenomedullin Gene Is a Target for Negative Regulation by the Myc Transcription Complex Mol. Endocrinol., February 1, 1999; 13(2): 254 - 267. [Abstract] [Full Text]
|
|
|
|
|
|
T. C. Lee and E. B. Ziff Mxi1 Is a Repressor of the c-myc Promoter and Reverses Activation by USF J. Biol. Chem., January 8, 1999; 274(2): 595 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mimura, M. Ema, K. Sogawa, and Y. Fujii-Kuriyama Identification of a novel mechanism of regulation of Ah (dioxin) receptor function Genes & Dev., January 1, 1999; 13(1): 20 - 25. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Zeng, C.-M. Tang, Y.-L. Yao, W.-M. Yang, and E. Seto Cloning and Characterization of the Mouse Histone Deacetylase-2 Gene J. Biol. Chem., October 30, 1998; 273(44): 28921 - 28930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Harris, E. D. E. Liaudet-Coopman, B. J. Boyle, A. Wellstein, and A. T. Riegel Phorbol Ester-induced Transcription of a Fibroblast Growth Factor-binding Protein Is Modulated by a Complex Interplay of Positive and Negative Regulatory Promoter Elements J. Biol. Chem., July 24, 1998; 273(30): 19130 - 19139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Price, H.-F. Ding, T. Badalian, S. Bhattacharya, C. Takemoto, T.-P. Yao, T. J. Hemesath, and D. E. Fisher Lineage-specific Signaling in Melanocytes. c-Kit STIMULATION RECRUITS p300/CBP TO MICROPHTHALMIA J. Biol. Chem., July 17, 1998; 273(29): 17983 - 17986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sommer, K. Bousset, E. Kremmer, M. Austen, and B. Luscher Identification and Characterization of Specific DNA-binding Complexes Containing Members of the Myc/Max/Mad Network of Transcriptional Regulators J. Biol. Chem., March 20, 1998; 273(12): 6632 - 6642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Tenen, R. Hromas, J. D. Licht, and D.-E. Zhang Transcription Factors, Normal Myeloid Development, and Leukemia Blood, July 15, 1997; 90(2): 489 - 519. [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, S. Fan, and E. V. Prochownik Distinct Roles for MAX Protein Isoforms in Proliferation and Apoptosis J. Biol. Chem., July 11, 1997; 272(28): 17416 - 17424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P J Hurlin, C Queva, and R N Eisenman Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes & Dev., January 1, 1997; 11(1): 44 - 58. [Abstract] [PDF]
|
|
|
|
|
|
T J Hemesath, E Steingrimsson, G McGill, M J Hansen, J Vaught, C A Hodgkinson, H Arnheiter, N G Copeland, N A Jenkins, and D E Fisher microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes & Dev., November 15, 1994; 8(22): 2770 - 2780. [Abstract] [PDF]
|
|
|
|
 |
|
 W Gu, K Bhatia, I. Magrath, C. Dang, and R Dalla-Favera Binding and suppression of the Myc transcriptional activation domain by p107 Science, April 8, 1994; 264(5156): 251 - 254. [Abstract] [PDF]
|
|
|
|
|
|
S. R. Biggar and G. R. Crabtree Chemically Regulated Transcription Factors Reveal the Persistence of Repressor-resistant Transcription after Disrupting Activator Function J. Biol. Chem., August 11, 2000; 275(33): 25381 - 25390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ogretmen, J. M. Kraveka, D. Schady, J. Usta, Y. A. Hannun, and L. M. Obeid Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line J. Biol. Chem., August 24, 2001; 276(35): 32506 - 32514. [Abstract] [Full Text] [PDF]
|
|
