![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Department of Anatomy, University of California, San Francisco 94143-0750.
Abstract
We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages. mRNA and protein for IGF-II were expressed in preimplantation mouse embryos, but the related factors IGF-I and insulin were not. IGF-I and insulin receptors and the IGF-II/mannose-6-phosphate receptor were expressed. Exogenous IGF-II or IGF-I increased the cell number in cultured blastocysts, but a mutant form of IGF-II that strongly binds only the IGF-II receptor did not. Reduction of IGF-II expression by antisense IGF-II oligonucleotides decreased the rate of progression to the blastocyst stage and decreased the cell number in blastocysts. Preimplantation parthenogenetic mouse embryos expressed mRNA for the IGF-II receptor but not for either IGF-II ligand or the IGF-I receptor, indicating that the latter genes are not expressed when inherited maternally. These data imply that some growth factors and receptors, regulated by genomic imprinting, may control cell proliferation from the earliest stages of embryonic development.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Navarrete Santos, N. Ramin, S. Tonack, and B. Fischer Cell Lineage-Specific Signaling of Insulin and Insulin-Like Growth Factor I in Rabbit Blastocysts Endocrinology, February 1, 2008; 149(2): 515 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Thurston, J. Taylor, J. Gardner, K. D Sinclair, and L. E Young Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage Reproduction, January 1, 2008; 135(1): 29 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Acevedo, J. Ding, and G. D Smith Insulin Signaling in Mouse Oocytes Biol Reprod, November 1, 2007; 77(5): 872 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Mellott, M. T. Follettie, V. Diesl, A. A. Hill, I. Lopez-Coviella, and J. K. Blusztajn Prenatal choline availability modulates hippocampal and cerebral cortical gene expression FASEB J, May 1, 2007; 21(7): 1311 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawamura, N. Kawamura, J. Kumagai, J. Fukuda, and T. Tanaka Tumor Necrosis Factor Regulation of Apoptosis in Mouse Preimplantation Embryos and Its Antagonism by Transforming Growth Factor Alpha/Phosphatidylionsitol 3-Kinase Signaling System Biol Reprod, April 1, 2007; 76(4): 611 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, E. Duan, L.-y. Sung, B.-S. Jeong, X. Yang, and X. C. Tian Generation and Characterization of Pluripotent Stem Cells from Cloned Bovine Embryos Biol Reprod, July 1, 2005; 73(1): 149 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Daimon and Y. Wada Role of Neutrophils in Matrix Metalloproteinase Activity in the Preimplantation Mouse Uterus Biol Reprod, July 1, 2005; 73(1): 163 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Edwards, K. L. Kind, D. T. Armstrong, and J. G. Thompson Effects of recombinant human follicle-stimulating hormone on embryo development in mice Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E845 - E851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Navarrete Santos, S. Tonack, M. Kirstein, S. Kietz, and B. Fischer Two insulin-responsive glucose transporter isoforms and the insulin receptor are developmentally expressed in rabbit preimplantation embryos Reproduction, November 1, 2004; 128(5): 503 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hamatani, T. Daikoku, H. Wang, H. Matsumoto, M. G. Carter, M. S. H. Ko, and S. K. Dey Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation PNAS, July 13, 2004; 101(28): 10326 - 10331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. N. Han, M. Post, A. K. Tanswell, and S. J. Lye Insulin-Like Growth Factor-I Receptor-Mediated Vasculogenesis/Angiogenesis in Human Lung Development Am. J. Respir. Cell Mol. Biol., February 1, 2003; 28(2): 159 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yoshiko, K. Hirao, and N. Maeda Differentiation in C2C12 myoblasts depends on the expression of endogenous IGFs and not serum depletion Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1278 - C1286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wrenzycki, A. Lucas-Hahn, D. Herrmann, E. Lemme, K. Korsawe, and H. Niemann In Vitro Production and Nuclear Transfer Affect Dosage Compensation of the X-Linked Gene Transcripts G6PD, PGK, and Xist in Preimplantation Bovine Embryos Biol Reprod, January 1, 2002; 66(1): 127 - 134. [Abstract] [Full Text]
|
|
|
|
|
|
T. Stojanov and C. O'Neill In Vitro Fertilization Causes Epigenetic Modifications to the Onset of Gene Expression from the Zygotic Genome in Mice Biol Reprod, February 1, 2001; 64(2): 696 - 705. [Abstract] [Full Text]
|
|
|
|
|
|
M. O. Carayannopoulos, M. M.-Y. Chi, Y. Cui, J. M. Pingsterhaus, R. A. McKnight, M. Mueckler, S. U. Devaskar, and K. H. Moley GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst PNAS, June 20, 2000; 97(13): 7313 - 7318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Herrler, J. M. Pell, W.R. Allen, H.M. Beier, and F. Stewart Horse Conceptuses Secrete Insulin-Like Growth Factor-Binding Protein 3 Biol Reprod, June 1, 2000; 62(6): 1804 - 1811. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Desai, J. Lawson, and J. Goldfarb Assessment of growth factor effects on post-thaw development of cryopreserved mouse morulae to the blastocyst stage Hum. Reprod., February 1, 2000; 15(2): 410 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Kaye and H. G. Gardner Preimplantation access to maternal insulin and albumin increases fetal growth rate in mice Hum. Reprod., December 1, 1999; 14(12): 3052 - 3059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kowalik, H-C. Liu, Z-Y. He, C. Mele, L. Barmat, and Z. Rosenwaks Expression of the insulin-like growth factor-1 gene and its receptor in preimplantation mouse embryos; is it a marker of embryo viability? Mol. Hum. Reprod., September 1, 1999; 5(9): 861 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Meier, E. Parmantier, A. Brennan, R. Mirsky, and K. R. Jessen Developing Schwann Cells Acquire the Ability to Survive without Axons by Establishing an Autocrine Circuit Involving Insulin-Like Growth Factor, Neurotrophin-3, and Platelet-Derived Growth Factor-BB J. Neurosci., May 15, 1999; 19(10): 3847 - 3859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Stojanov and C. O'Neill Ontogeny of Expression of a Receptor for Platelet-Activating Factor in Mouse Preimplantation Embryos and the Effects of Fertilization and Culture In Vitro on Its Expression Biol Reprod, March 1, 1999; 60(3): 674 - 682. [Abstract] [Full Text]
|
|
|
|
|
|
T. Stojanov, S. Alechna, and C. O'Neill In-vitro fertilization and culture of mouse embryos in vitro significantly retards the onset of insulin-like growth factor-II expression from the zygotic genome Mol. Hum. Reprod., February 1, 1999; 5(2): 116 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Herrler, C. A. Krusche, and H. M. Beier Insulin and Insulin-like Growth Factor-I Promote Rabbit Blastocyst Development and Prevent Apoptosis Biol Reprod, December 1, 1998; 59(6): 1302 - 1310. [Abstract] [Full Text]
|
|
|
|
|
|
A. V. Morales, J. Serna, C. Alarcon, E. J. de la Rosa, and F. de Pablo Role of Prepancreatic (Pro)Insulin and the Insulin Receptor in Prevention of Embryonic Apoptosis Endocrinology, September 1, 1997; 138(9): 3967 - 3975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pantaleon, E. J. Whiteside, M. B. Harvey, R. T. Barnard, M. J. Waters, and P. L. Kaye Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: A role for GH in early embryogenesis? PNAS, May 13, 1997; 94(10): 5125 - 5130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Fleur, J. L. Underwood, D. A. Rappolee, and Z. Werb Basement Membrane and Repair of Injury to Peripheral Nerve: Defining a Potential Role for Macrophages, Matrix Metalloproteinases, and Tissue Inhibitor of Metalloproteinases-1 J. Exp. Med., December 15, 1996; 184(6): 2311 - 2326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Liu, H. Yan, N. J. Dawes, G. A. Mottino, J. S. Frank, and H. Zhu Insulin-like Growth Factor II Induces DNA Synthesis in Fetal Ventricular Myocytes In Vitro Circ. Res., October 1, 1996; 79(4): 716 - 726. [Abstract] [Full Text]
|
|
|
|
 |
|
 P E Szabo and J R Mann Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms. Genes & Dev., December 15, 1995; 9(24): 3097 - 3108. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Newman-Smith and Z Werb Stem cell defects in parthenogenetic peri-implantation embryos Development, January 7, 1995; 121(7): 2069 - 2077. [Abstract] [PDF]
|
|
|
|
 |
|
 A Blangy, F Vidal, F Cuzin, Y. Yang, K Boulukos, and M Rassoulzadegan CDEBP, a site-specific DNA-binding protein of the 'APP-like' family, is required during the early development of the mouse J. Cell Sci., January 2, 1995; 108(2): 675 - 683. [Abstract] [PDF]
|
|
|
|
|
|
K E Latham, A S Doherty, C D Scott, and R M Schultz Igf2r and Igf2 gene expression in androgenetic, gynogenetic, and parthenogenetic preimplantation mouse embryos: absence of regulation by genomic imprinting. Genes & Dev., February 1, 1994; 8(3): 290 - 299. [Abstract] [PDF]
|
|
|
|
|
|
D. Rappolee, C Basilico, Y Patel, and Z Werb Expression and function of FGF-4 in peri-implantation development in mouse embryos Development, January 8, 1994; 120(8): 2259 - 2269. [Abstract] [PDF]
|
|
|
|
|
|
L Shum, Y Sakakura, P Bringas, W Luo, M. Snead, M Mayo, C Crohin, S Millar, Z Werb, S Buckley, et al. EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro Development, January 7, 1993; 118(3): 903 - 917. [Abstract] [PDF]
|
|
|
|
|
|
A Mac Auley, Z Werb, and P. Mirkes Characterization of the unusually rapid cell cycles during rat gastrulation Development, January 3, 1993; 117(3): 873 - 883. [Abstract] [PDF]
|
|
|
|
|
|
R. Albano, N Groome, and J. Smith Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation Development, January 2, 1993; 117(2): 711 - 723. [Abstract] [PDF]
|
|
