![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305-5427.
Abstract
The bacterial chemotaxis signal transducer MCP is an integral membrane receptor protein. The chemoreceptor is localized at the flagellum-bearing pole of Caulobacter crescentus swarmer cells. Amino-terminal sequences of the MCP target the protein to the membrane while the carboxy-terminal portion of the protein is responsible for polar localization. The C. crescentus and Escherichia coli MCPs have highly conserved carboxy-terminal domains, and when an E. coli MCP is expressed in C. crescentus, it is targeted to the swarmer cell progeny. These results suggest that subcellular localization of a prokaryotic protein involves interaction of specific regions of the protein with unique cell sites that contain either localized binding proteins or a specific secretory apparatus.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. K. Radhakrishnan, M. Thanbichler, and P. H. Viollier The dynamic interplay between a cell fate determinant and a lysozyme homolog drives the asymmetric division cycle of Caulobacter crescentus Genes & Dev., January 15, 2008; 22(2): 212 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Norris, T. den Blaauwen, A. Cabin-Flaman, R. H. Doi, R. Harshey, L. Janniere, A. Jimenez-Sanchez, D. J. Jin, P. A. Levin, E. Mileykovskaya, et al. Functional Taxonomy of Bacterial Hyperstructures Microbiol. Mol. Biol. Rev., March 1, 2007; 71(1): 230 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Iniesta, P. T. McGrath, A. Reisenauer, H. H. McAdams, and L. Shapiro A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle progression PNAS, July 18, 2006; 103(29): 10935 - 10940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Levi and U. Jenal Holdfast Formation in Motile Swarmer Cells Optimizes Surface Attachment during Caulobacter crescentus Development. J. Bacteriol., July 1, 2006; 188(14): 5315 - 5318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-A. Jimenez-Pearson, I. Delany, V. Scarlato, and D. Beier Phosphate flow in the chemotactic response system of Helicobacter pylori Microbiology, October 1, 2005; 151(10): 3299 - 3311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nilsen, A. W. Yan, G. Gale, and M. B. Goldberg Presence of Multiple Sites Containing Polar Material in Spherical Escherichia coli Cells That Lack MreB J. Bacteriol., September 1, 2005; 187(17): 6187 - 6196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lux and W. Shi CHEMOTAXIS-GUIDED MOVEMENTS IN BACTERIA Crit. Rev. Oral. Biol. Med., July 1, 2004; 15(4): 207 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Viollier, M. Thanbichler, P. T. McGrath, L. West, M. Meewan, H. H. McAdams, and L. Shapiro From The Cover: Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication PNAS, June 22, 2004; 101(25): 9257 - 9262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Szurmant and G. W. Ordal Diversity in Chemotaxis Mechanisms among the Bacteria and Archaea Microbiol. Mol. Biol. Rev., June 1, 2004; 68(2): 301 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kondou, N. Mogami, F. Hoshi, S. Kutsuna, M. Nakazawa, T. Sakurai, M. Matsui, T. Kaneko, S. Tabata, I. Tanaka, et al. Bipolar Localization of Putative Photoreceptor Protein for Phototaxis in Thermophilic Cyanobacterium Synechococcus elongatus Plant Cell Physiol., December 15, 2002; 43(12): 1585 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Shapiro, H. H. McAdams, and R. Losick Generating and Exploiting Polarity in Bacteria Science, December 6, 2002; 298(5600): 1942 - 1946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Potocka, M. Thein, M. Osteras, U. Jenal, and M. R. K. Alley Degradation of a Caulobacter Soluble Cytoplasmic Chemoreceptor Is ClpX Dependent J. Bacteriol., December 1, 2002; 184(23): 6635 - 6641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Viollier, N. Sternheim, and L. Shapiro Identification of a localization factor for the polar positioning of bacterial structural and regulatory proteins PNAS, October 15, 2002; 99(21): 13831 - 13836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Lamanna, J. E. Gestwicki, L. E. Strong, S. L. Borchardt, R. M. Owen, and L. L. Kiessling Conserved Amplification of Chemotactic Responses through Chemoreceptor Interactions J. Bacteriol., September 15, 2002; 184(18): 4981 - 4987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Z. Rudner, Q. Pan, and R. M. Losick Evidence that subcellular localization of a bacterial membrane protein is achieved by diffusion and capture PNAS, June 25, 2002; 99(13): 8701 - 8706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Stock, M. N. Levit, and P. M. Wolanin Information Processing in Bacterial Chemotaxis Sci. Signal., May 14, 2002; 2002(132): pe25 - pe25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Bourret and A. M. Stock Molecular Information Processing: Lessons from Bacterial Chemotaxis J. Biol. Chem., March 15, 2002; 277(12): 9625 - 9628. [Full Text] [PDF]
|
|
|
|
|
|
L. L. McCarter Polar Flagellar Motility of the Vibrionaceae Microbiol. Mol. Biol. Rev., September 1, 2001; 65(3): 445 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-W. Tsai and M. R. K. Alley Proteolysis of the Caulobacter McpA Chemoreceptor Is Cell Cycle Regulated by a ClpX-Dependent Pathway J. Bacteriol., September 1, 2001; 183(17): 5001 - 5007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Charles, M. Perez, J. H. Kobil, and M. B. Goldberg Polar targeting of Shigella virulence factor IcsA in Enterobacteriacae and Vibrio PNAS, July 24, 2001; (2001) 171310498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Lybarger and J. R. Maddock Polarity in Action: Asymmetric Protein Localization in Bacteria J. Bacteriol., June 1, 2001; 183(11): 3261 - 3267. [Full Text]
|
|
|
|
|
|
S. E. Jones, N. L. Ferguson, and M. R. K. Alley New members of the ctrA regulon: the major chemotaxis operon in Caulobacter is CtrA dependent Microbiology, April 1, 2001; 147(4): 949 - 958. [Abstract] [Full Text]
|
|
|
|
|
|
C. Jacobs, D. Hung, and L. Shapiro Dynamic localization of a cytoplasmic signal transduction response regulator controls morphogenesis during the Caulobacter cell cycle PNAS, March 7, 2001; (2001) 51609998. [Abstract] [Full Text]
|
|
|
|
|
|
J. E. Gestwicki, A. C. Lamanna, R. M. Harshey, L. L. McCarter, L. L. Kiessling, and J. Adler Evolutionary Conservation of Methyl-Accepting Chemotaxis Protein Location in Bacteria and Archaea J. Bacteriol., November 15, 2000; 182(22): 6499 - 6502. [Abstract] [Full Text]
|
|
|
|
|
|
S. R. Lybarger and J. R. Maddock Differences in the polar clustering of the high- and low-abundance chemoreceptors of Escherichia coli PNAS, June 14, 2000; (2000) 130195397. [Abstract] [Full Text]
|
|
|
|
|
|
J. M. Skidmore, D. D. Ellefson, B. P. McNamara, M. M. P. Couto, A. J. Wolfe, and J. R. Maddock Polar Clustering of the Chemoreceptor Complex in Escherichia coli Occurs in the Absence of Complete CheA Function J. Bacteriol., February 15, 2000; 182(4): 967 - 973. [Abstract] [Full Text]
|
|
|
|
|
|
J.-W. Tsai and M. R. K. Alley Proteolysis of the McpA Chemoreceptor Does Not Require the Caulobacter Major Chemotaxis Operon J. Bacteriol., January 15, 2000; 182(2): 504 - 507. [Abstract] [Full Text]
|
|
|
|
|
|
R. B. Jensen and L. Shapiro The Caulobacter crescentus smc gene is required for cell cycle progression and chromosome segregation PNAS, September 14, 1999; 96(19): 10661 - 10666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Losick and L. Shapiro Changing Views on the Nature of the Bacterial Cell: from Biochemistry to Cytology J. Bacteriol., July 15, 1999; 181(14): 4143 - 4145. [Full Text]
|
|
|
|
|
|
L. Shapiro and R. Losick Protein Localization and Cell Fate in Bacteria Science, May 2, 1997; 276(5313): 712 - 718. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Wingrove and J. W. Gober Identification of an Asymmetrically Localized Sensor Histidine Kinase Responsible for Temporally and Spatially Regulated Transcription Science, October 25, 1996; 274(5287): 597 - 601. [Abstract] [Full Text]
|
|
|
|
|
|
R Wright, C Stephens, G Zweiger, L Shapiro, and M R Alley Caulobacter Lon protease has a critical role in cell-cycle control of DNA methylation. Genes & Dev., June 15, 1996; 10(12): 1532 - 1542. [Abstract] [PDF]
|
|
|
|
|
|
J A Wingrove and J W Gober A sigma 54 transcriptional activator also functions as a pole-specific repressor in Caulobacter. Genes & Dev., August 1, 1994; 8(15): 1839 - 1852. [Abstract] [PDF]
|
|
|
|
|
|
J A Wingrove, E K Mangan, and J W Gober Spatial and temporal phosphorylation of a transcriptional activator regulates pole-specific gene expression in Caulobacter. Genes & Dev., October 1, 1993; 7(10): 1979 - 1992. [Abstract] [PDF]
|
|
|
|
|
|
Maddock JR and L Shapiro Polar location of the chemoreceptor complex in the Escherichia coli cell Science, March 19, 1993; 259(5102): 1717 - 1723. [Abstract] [PDF]
|
|
|
|
|
|
M. Alley, Maddock JR, and L Shapiro Requirement of the carboxyl terminus of a bacterial chemoreceptor for its targeted proteolysis Science, March 19, 1993; 259(5102): 1754 - 1757. [Abstract] [PDF]
|
|
|
|
|
|
Y V Brun and L Shapiro A temporally controlled sigma-factor is required for polar morphogenesis and normal cell division in Caulobacter. Genes & Dev., December 1, 1992; 6(12a): 2395 - 2408. [Abstract] [PDF]
|
|
|
|
|
|
W. Nelson Regulation of cell surface polarity from bacteria to mammals Science, November 6, 1992; 258(5084): 948 - 955. [Abstract] [PDF]
|
|
|
|
|
|
R. B. Bourret and A. M. Stock Molecular Information Processing: Lessons from Bacterial Chemotaxis J. Biol. Chem., March 15, 2002; 277(12): 9625 - 9628. [Full Text] [PDF]
|
|
|
|
|
|
C. Jacobs, D. Hung, and L. Shapiro Dynamic localization of a cytoplasmic signal transduction response regulator controls morphogenesis during the Caulobacter cell cycle PNAS, March 27, 2001; 98(7): 4095 - 4100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Lybarger and J. R. Maddock Differences in the polar clustering of the high- and low-abundance chemoreceptors of Escherichia coli PNAS, July 5, 2000; 97(14): 8057 - 8062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Charles, M. Perez, J. H. Kobil, and M. B. Goldberg Polar targeting of Shigella virulence factor IcsA in Enterobacteriacae and Vibrio PNAS, August 14, 2001; 98(17): 9871 - 9876. [Abstract] [Full Text] [PDF]
|
|
