![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Abstract
Myogenin and MyoD belong to a family of muscle-specific helix-loop-helix (HLH) proteins that have the potential to activate muscle-specific genes in nonmyogenic cells. Peptide growth factors can block the ability of myogenin and MyoD to activate their target genes. Here, we show that the growth factor-inducible proto-oncogenes c-fos, c-jun, and junB mimic the effects of exogenous growth factors and suppress trans-activation of the muscle creatine kinase (MCK) enhancer by myogenin and MyoD. In contrast, JunD, which shares DNA-binding specificity with JunB and c-Jun but is expressed constitutively in muscle cells, is an inefficient inhibitor of the trans-activating capacity of myogenin and MyoD. Transcriptional repression by Fos and Jun is specific to myogenic HLH proteins and is not observed with the widely expressed HLH protein E47, which recognizes the same DNA sequence. Repression of the MCK enhancer by Fos and Jun is targeted at the myogenin and MyoD DNA recognition sequence and can be mediated by the amino terminus of c-Jun. Comparison of several myogenin mutants for their responsiveness to Fos and Jun shows that repression is directed at the basic-HLH region. These results indicate that members of the Jun family can be distinguished on the basis of their effects on muscle-specific transcription and suggest there is cross talk between transcription factors that control myogenesis and those involved in cell proliferation.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Iwasaki, K. Hayashi, T. Fujioka, and K. Sobue Rho/Rho-associated Kinase Signal Regulates Myogenic Differentiation via Myocardin-related Transcription Factor-A/Smad-dependent Transcription of the Id3 Gene J. Biol. Chem., July 25, 2008; 283(30): 21230 - 21241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R Manna and D. M Stocco Crosstalk of CREB and Fos/Jun on a single cis-element: transcriptional repression of the steroidogenic acute regulatory protein gene J. Mol. Endocrinol., October 1, 2007; 39(4): 261 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jethanandani and R. H. Kramer {alpha}7 Integrin Expression Is Negatively Regulated by {delta}EF1 during Skeletal Myogenesis J. Biol. Chem., October 28, 2005; 280(43): 36037 - 36046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Grandemange, P. Seyer, A. Carazo, P. Becuwe, L. Pessemesse, M. Busson, C. Marsac, P. Roger, F. Casas, G. Cabello, et al. Stimulation of Mitochondrial Activity by p43 Overexpression Induces Human Dermal Fibroblast Transformation Cancer Res., May 15, 2005; 65(10): 4282 - 4291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Vinals and F. Ventura Myogenin Protein Stability Is Decreased by BMP-2 through a Mechanism Implicating Id1 J. Biol. Chem., October 29, 2004; 279(44): 45766 - 45772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. N. Farrow, A. P. Bradford, J. J. Tentler, and A. Gutierrez-Hartmann Structural and Functional Analysis of the Differential Effects of c-Jun and v-Jun on Prolactin Gene Expression Mol. Endocrinol., October 1, 2004; 18(10): 2479 - 2490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ardite, J. A. Barbera, J. Roca, and J. C. Fernandez-Checa Glutathione Depletion Impairs Myogenic Differentiation of Murine Skeletal Muscle C2C12 Cells through Sustained NF-{kappa}B Activation Am. J. Pathol., September 1, 2004; 165(3): 719 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Matsumoto, D. Einhaus, E. S. Gold, and A. Aderem Simvastatin Augments Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages by Differential Regulation of the c-Fos and c-Jun Transcription Factors J. Immunol., June 15, 2004; 172(12): 7377 - 7384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Manna, D. W. Eubank, and D. M. Stocco Assessment of the Role of Activator Protein-1 on Transcription of the Mouse Steroidogenic Acute Regulatory Protein Gene Mol. Endocrinol., March 1, 2004; 18(3): 558 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Crist, T. S. Griffith, and T. L. Ratliff Structure/Function Analysis of the Murine CD95L Promoter Reveals the Identification of a Novel Transcriptional Repressor and Functional CD28 Response Element J. Biol. Chem., September 19, 2003; 278(38): 35950 - 35958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kami and E. Senba In Vivo Activation of STAT3 Signaling in Satellite Cells and Myofibers in Regenerating Rat Skeletal Muscles J. Histochem. Cytochem., December 1, 2002; 50(12): 1579 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Ostrovsky, E. Bengal, and A. Aronheim Induction of Terminal Differentiation by the c-Jun Dimerization Protein JDP2 in C2 Myoblasts and Rhabdomyosarcoma Cells J. Biol. Chem., October 11, 2002; 277(42): 40043 - 40054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Eriksson and S. Leppa Mitogen-activated Protein Kinases and Activator Protein 1 Are Required for Proliferation and Cardiomyocyte Differentiation of P19 Embryonal Carcinoma Cells J. Biol. Chem., May 3, 2002; 277(18): 15992 - 16001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Andreucci, D. Grant, D. M. Cox, L. K. Tomc, R. Prywes, D. J. Goldhamer, N. Rodrigues, P.-A. Bedard, and J. C. McDermott Composition and Function of AP-1 Transcription Complexes during Muscle Cell Differentiation J. Biol. Chem., May 3, 2002; 277(19): 16426 - 16432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. K. Schaefer, S. Wang, and T. S. Schaefer Functional Interaction of Jun and Homeodomain Proteins J. Biol. Chem., November 9, 2001; 276(46): 43074 - 43082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ranganath and K. M. Murphy Structure and Specificity of GATA Proteins in Th2 Development Mol. Cell. Biol., April 15, 2001; 21(8): 2716 - 2725. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Meriane, P. Roux, M. Primig, P. Fort, and C. Gauthier-Rouvière Critical Activities of Rac1 and Cdc42Hs in Skeletal Myogenesis: Antagonistic Effects of JNK and p38 Pathways Mol. Biol. Cell, August 1, 2000; 11(8): 2513 - 2528. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. L. Puri, Z. Wu, P. Zhang, L. D. Wood, K. S. Bhakta, J. Han, J. R. Feramisco, M. Karin, and J. Y.J. Wang Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells Genes & Dev., March 1, 2000; 14(5): 574 - 584. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Si, Q. Wang, and L. Mei Essential Roles of c-JUN and c-JUN N-Terminal Kinase (JNK) in Neuregulin-Increased Expression of the Acetylcholine Receptor epsilon -Subunit J. Neurosci., October 1, 1999; 19(19): 8498 - 8508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schreiber, A. Kolbus, F. Piu, A. Szabowski, U. Möhle-Steinlein, J. Tian, M. Karin, P. Angel, and E. F. Wagner Control of cell cycle progression by c-Jun is p53 dependent Genes & Dev., March 1, 1999; 13(5): 607 - 619. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. E. Reyland, D. L. Williams, and E. K. White Inducible expression of protein kinase Calpha suppresses steroidogenesis in Y-1 adrenocortical cells Am J Physiol Cell Physiol, September 1, 1998; 275(3): C780 - C789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Rutherford and D. P. LeBrun Restricted Expression of E2A Protein in Primary Human Tissues Correlates with Proliferation and Differentiation Am. J. Pathol., July 1, 1998; 153(1): 165 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Chalaux, T. Lopez-Rovira, J. L. Rosa, R. Bartrons, and F. Ventura JunB Is Involved in the Inhibition of Myogenic Differentiation by Bone Morphogenetic Protein-2 J. Biol. Chem., January 2, 1998; 273(1): 537 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Duval, S. E. Nelson, and C. M. Clay The Tripartite Basal Enhancer of the Gonadotropin-Releasing Hormone (GnRH) Receptor Gene Promoter Regulates Cell-Specific Expression Through a Novel GnRH Receptor Activating Sequence Mol. Endocrinol., November 1, 1997; 11(12): 1814 - 1821. [Abstract] [Full Text]
|
|
|
|
|
|
A. Sharma, E. Henderson, L. Gamer, Y. Zhuang, and R. Stein Analysis of the Role of E2A-Encoded Proteins in Insulin Gene Transcription Mol. Endocrinol., October 1, 1997; 11(11): 1608 - 1617. [Abstract] [Full Text]
|
|
|
|
|
|
C. K. Babichuk and R. C. Bleackley Mutational Analysis of the Murine Granzyme B Gene Promoter in Primary T Cells and a T Cell Clone J. Biol. Chem., July 25, 1997; 272(30): 18564 - 18571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chu, J. Cogswell, and D. S. Kohtz MyoD Functions as a Transcriptional Repressor in Proliferating Myoblasts J. Biol. Chem., February 7, 1997; 272(6): 3145 - 3148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Aurade, C. Pfarr, C Lindon, A Garcia, M Primig, D Montarras, and C Pinset The glucocorticoid receptor and AP-1 are involved in a positive regulation of the muscle regulatory gene myf5 in cultured myoblasts J. Cell Sci., January 11, 1997; 110(22): 2771 - 2779. [Abstract] [PDF]
|
|
|
|
|
|
P. Kaliman, F. Vinals, X. Testar, M. Palacin, and A. Zorzano Phosphatidylinositol 3-Kinase Inhibitors Block Differentiation of Skeletal Muscle Cells J. Biol. Chem., August 9, 1996; 271(32): 19146 - 19151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Farrow, N. Manning, F. Schaufele, and A. Gutierrez-Hartmann The c-Jun delta -Domain Inhibits Neuroendocrine Promoter Activity in a DNA Sequence- and Pituitary-specific Manner J. Biol. Chem., July 19, 1996; 271(29): 17139 - 17146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E N Olson and W H Klein bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes & Dev., January 1, 1994; 8(1): 1 - 8. [PDF]
|
|
|
|
|
|
M Hibi, A Lin, T Smeal, A Minden, and M Karin Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes & Dev., November 1, 1993; 7(11): 2135 - 2148. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Smith, N. Block, S. Rhodes, S. Konieczny, and J. Miller A unique pattern of expression of the four muscle regulatory factor proteins distinguishes somitic from embryonic, fetal and newborn mouse myogenic cells Development, January 3, 1993; 117(3): 1125 - 1133. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Agoff, J Hou, D. Linzer, and B Wu Regulation of the human hsp70 promoter by p53 Science, January 1, 1993; 259(5091): 84 - 87. [Abstract] [PDF]
|
|
|
|
|
|
S Oliviero, G S Robinson, K Struhl, and B M Spiegelman Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation. Genes & Dev., September 1, 1992; 6(9): 1799 - 1809. [Abstract] [PDF]
|
|
|
|
|
|
C. M. Dorman and S. E. Johnson Activated Raf Inhibits Myogenesis through a Mechanism Independent of Activator Protein 1-mediated Myoblast Transformation J. Biol. Chem., August 25, 2000; 275(35): 27481 - 27487. [Abstract] [Full Text] [PDF]
|
|
