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Research Papers
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Abstract
The retroviral integration site Fli-1 is rearranged in 75% of the erythroleukemia cell clones induced by Friend murine leukemia virus (F-MuLV), whereas Spi-1/PU.1, a member of the ets family of DNA-binding proteins, is rearranged in 95% of the erythroleukemias induced by Friend spleen focus-forming virus (SFFV). To determine the transcriptional domain defined by Fli-1, we have isolated a cDNA clone that is highly expressed only in erythroleukemia cell lines with Fli-1 rearrangements. The protein sequence of this cDNA is very similar to Erg2, another member of the ets gene family. The hydrophilic carboxy-terminal end of the Fli-1 cDNA shares significant sequence similarity to the DNA-binding ETS domain found in all members of the ets family. PFGE analysis localized Fli-1 within 240 kb of the ets-1 proto-oncogene on mouse chromosome 9 and human chromosome 11q23, suggesting that ets-1 and Fli-1 arose from a common ancestral gene by gene duplication. The involvement of the murine Fli-1, Spi-1, and avian v-ets genes in erythroleukemia induction suggests that activation of ets gene family members plays an important role in the progression of these multistage malignancies.
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 T. Ezashi, A. D. Ealy, M. C. Ostrowski, and R. M. Roberts Control of interferon-tau gene expression by Ets-2 PNAS, July 7, 1998; 95(14): 7882 - 7887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Fisher and E. W. Scott Role of PU.1 in Hematopoiesis Stem Cells, January 1, 1998; 16(1): 25 - 37. [Abstract] [Full Text]
|
|
|
|
|
|
M. Carroll, M. H. Tomasson, G. F. Barker, T. R. Golub, and D. G. Gilliland The TEL/platelet-derived growth factor beta receptor (PDGFbeta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFbeta R kinase-dependent signaling pathways PNAS, December 10, 1996; 93(25): 14845 - 14850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Martin, Y. Chinenov, M. Yu, T. K. Schmidt, and X.-Y. Yang Redox Regulation of GA-binding Protein-alpha DNA Binding Activity J. Biol. Chem., October 11, 1996; 271(41): 25617 - 25623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Trejo, W. E. Fahl, and L. Ratner c-sis/PDGF-B Promoter Transactivation by the Tax Protein of Human T-cell Leukemia Virus Type 1 J. Biol. Chem., June 14, 1996; 271(24): 14584 - 14590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Giese, C Kingsley, J R Kirshner, and R Grosschedl Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes & Dev., April 15, 1995; 9(8): 995 - 1008. [Abstract] [PDF]
|
|
|
|
|
|
N Kraut, J Frampton, K M McNagny, and T Graf A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets. Genes & Dev., January 1, 1994; 8(1): 33 - 44. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Wang, B Petryniak, C. Thompson, W. Kaelin, and J. Leiden Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein Science, May 28, 1993; 260(5112): 1330 - 1335. [Abstract] [PDF]
|
|
|
|
 |
|
 C Klambt The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells Development, January 1, 1993; 117(1): 163 - 176. [Abstract] [PDF]
|
|
|
|
|
|
T A Brown and S L McKnight Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes & Dev., December 1, 1992; 6(12b): 2502 - 2512. [Abstract] [PDF]
|
|
|
|
|
|
C Wasylyk, J P Kerckaert, and B Wasylyk A novel modulator domain of Ets transcription factors. Genes & Dev., June 1, 1992; 6(6): 965 - 974. [Abstract] [PDF]
|
|
|
|
|
|
J A Nye, J M Petersen, C V Gunther, M D Jonsen, and B J Graves Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes & Dev., June 1, 1992; 6(6): 975 - 990. [Abstract] [PDF]
|
|
|
|
|
|
J H Xin, A Cowie, P Lachance, and J A Hassell Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells. Genes & Dev., March 1, 1992; 6(3): 481 - 496. [Abstract] [PDF]
|
|
|
|
|
|
Y. Miyazaki, P. Boccuni, S. Mao, J. Zhang, H. Erdjument-Bromage, P. Tempst, H. Kiyokawa, and S. D. Nimer Cyclin A-dependent Phosphorylation of the ETS-related Protein, MEF, Restricts Its Activity to the G1 Phase of the Cell Cycle J. Biol. Chem., October 26, 2001; 276(44): 40528 - 40536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. KIM and J. PELLETIER Molecular genetics of chromosome translocations involving EWS and related family members Physiol Genomics, November 11, 1999; 1(3): 127 - 138. [Abstract] [Full Text] [PDF]
|
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