Genes and Development

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

GENES & DEVELOPMENT 4:1374-1383, 1990
ISSN 0890-9369
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thon, G
Right arrow Articles by Eisen, H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thon, G
Right arrow Articles by Eisen, H
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Research Papers

Trypanosome variable surface glycoproteins: composite genes and order of expression.

G Thon, T Baltz, C Giroud, and H Eisen

Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

Abstract

Combinatorial processes increase the diversity of variable surface glycoproteins (VSGs) expressed by Trypanosoma equiperdum. We show here that a single telomeric pseudogene provides the 3' portion of three distinct T. equiperdum VSG genes by recombination with different 5' donor pseudogenes. Regions of sequence homology among the pseudogenes determine the sites of recombination in the formation of the expressed copies. This suggests that the recombination between any given basic copy (BC) and the expression-linked copy (ELC) depends on their sharing homology. We present evidence that this is the case and propose that such rules account for the order of expression of the VSGs. These results demonstrate how homologous recombination can generate an ordered sequence of gene expression.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
Y. Zhuang, J. E. Futse, W. C. Brown, K. A. Brayton, and G. H. Palmer
Maintenance of Antibody to Pathogen Epitopes Generated by Segmental Gene Conversion Is Highly Dynamic during Long-Term Persistent Infection
Infect. Immun., November 1, 2007; 75(11): 5185 - 5190.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
L. Marcello and J. D. Barry
Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure
Genome Res., September 1, 2007; 17(9): 1344 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. A. Lythgoe, L. J. Morrison, A. F. Read, and J. D. Barry
Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation
PNAS, May 8, 2007; 104(19): 8095 - 8100.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. R. Stringer and S. P. Keely
Genetics of Surface Antigen Expression in Pneumocystis carinii
Infect. Immun., February 1, 2001; 69(2): 627 - 639.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
X Wu and J E Haber
MATa donor preference in yeast mating-type switching: activation of a large chromosomal region for recombination.
Genes & Dev., August 1, 1995; 9(15): 1922 - 1932.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genome Res. Learn. Mem.
Protein Science RNA Genes Dev.