.gif?ad=16839&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Institut für Biochemie, Ludwig-Maximilians-Universität, Munich, FRG.
Abstract
Transcription from one of the two initiation sites, P1 and P2, of the dual human MYC promoter seems to be essential in all proliferating cells. To identify proteins and target structures for MYC regulation, a DNA region was analyzed that is critical for P2 promoter activity. Here, we show that a nuclear factor binds to a DNA element within P2, which is conserved perfectly between mouse and man and displays a striking homology to the E1a-inducible E2 promoter of adenovirus type 5 (Ad5). We demonstrate that the same transcription factor, defined recently as E2F, which plays an essential role in the activation of adenovirus early promoters and enhancers, also interacts as a dominant nuclear factor with the MYC promoter. The presence of an intact E2F binding site is required for basic expression and for trans-activation of the P2 promoter by E1a proteins. The human MYC promoter is the first cellular target described for E2F. The results suggest that expression of MYC might be regulated via modulation of E2F by cellular 'E1a-like' factors.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Sylvestre, V. De Guire, E. Querido, U. K. Mukhopadhyay, V. Bourdeau, F. Major, G. Ferbeyre, and P. Chartrand An E2F/miR-20a Autoregulatory Feedback Loop J. Biol. Chem., January 26, 2007; 282(4): 2135 - 2143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-J. Kim, K.-G. Park, K.-M. Lee, H.-S. Kim, S.-Y. Kim, C.-S. Kim, S.-L. Lee, Y.-C. Chang, J.-Y. Park, K.-U. Lee, et al. Cilostazol Inhibits Vascular Smooth Muscle Cell Growth by Downregulation of the Transcription Factor E2F Hypertension, April 1, 2005; 45(4): 552 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. R. MacLellan, A. Garcia, H. Oh, P. Frenkel, M. C. Jordan, K. P. Roos, and M. D. Schneider Overlapping Roles of Pocket Proteins in the Myocardium Are Unmasked by Germ Line Deletion of p130 plus Heart-Specific Deletion of Rb Mol. Cell. Biol., March 15, 2005; 25(6): 2486 - 2497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Carbone, E. McGuffie, S. Napoli, C. E. Flanagan, C. Dembech, U. Negri, F. Arcamone, M. L. Capobianco, and C. V. Catapano DNA binding and antigene activity of a daunomycin-conjugated triplex-forming oligonucleotide targeting the P2 promoter of the human c-myc gene Nucleic Acids Res., April 30, 2004; 32(8): 2396 - 2410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lohr, O. Hartmann, H. Schafer, and M. Dobbelstein Mutual Interference of Adenovirus Infection and myc Expression J. Virol., July 15, 2003; 77(14): 7936 - 7944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lee, J. H. Chang, H. S. Lee, and Y. Cho Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor Genes & Dev., December 15, 2002; 16(24): 3199 - 3212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Endo, M. Takahashi, M. Kuraya, M. Matsushita, C. M. Stover, W. J. Schwaeble, and T. Fujita Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter Int. Immunol., October 1, 2002; 14(10): 1193 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. McGuffie and C. V. Catapano Design of a novel triple helix-forming oligodeoxyribonucleotide directed to the major promoter of the c-myc gene Nucleic Acids Res., June 15, 2002; 30(12): 2701 - 2709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Rounbehler, P. M. Rogers, C. J. Conti, and D. G. Johnson Inactivation of E2f1 Enhances Tumorigenesis in a Myc Transgenic Model Cancer Res., June 1, 2002; 62(11): 3276 - 3281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Harbour and D. C. Dean The Rb/E2F pathway: expanding roles and emerging paradigms Genes & Dev., October 1, 2000; 14(19): 2393 - 2409. [Full Text]
|
|
|
|
 |
|
 R. M. Gill and P. A. Hamel Subcellular Compartmentalization of E2F Family Members Is Required for Maintenance of the Postmitotic State in Terminally Differentiated Muscle J. Cell Biol., March 20, 2000; 148(6): 1187 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Grigorieva, V. G. Grigoriev, M. K. Rowney, and R. G. Hoover Regulation of c-myc Transcription by Interleukin-2 (IL-2). IDENTIFICATION OF A NOVEL IL-2 RESPONSE ELEMENT INTERACTING WITH STAT-4 J. Biol. Chem., March 15, 2000; 275(10): 7343 - 7350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. He, B. L. Cook, B. E. Deverman, U. Weihe, F. Zhang, V. Prachand, J. Zheng, and S. J. Weintraub E2F Is Required To Prevent Inappropriate S-Phase Entry of Mammalian Cells Mol. Cell. Biol., January 1, 2000; 20(1): 363 - 371. [Abstract] [Full Text]
|
|
|
|
|
|
E. Vigo, H. Muller, E. Prosperini, G. Hateboer, P. Cartwright, M. C. Moroni, and K. Helin CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase Mol. Cell. Biol., September 1, 1999; 19(9): 6379 - 6395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Izzo, G. D. Strachan, M. C. Stubbs, and D. J. Hall Transcriptional Repression from the c-myc P2 Promoter by the Zinc Finger Protein ZF87/MAZ J. Biol. Chem., July 2, 1999; 274(27): 19498 - 19506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Zheng, E. Fraenkel, C. O. Pabo, and N. P. Pavletich Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP Genes & Dev., March 15, 1999; 13(6): 666 - 674. [Abstract] [Full Text]
|
|
|
|
|
|
I. Wolf, V. Pevzner, E. Kaiser, G. Bernhardt, E. Claudio, U. Siebenlist, R. Forster, and M. Lipp Downstream Activation of a TATA-less Promoter by Oct-2, Bob1, and NF-kappa B Directs Expression of the Homing Receptor BLR1 to Mature B Cells J. Biol. Chem., October 30, 1998; 273(44): 28831 - 28836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tomita, M. Horiuchi, S. Tomita, G. H. Gibbons, J. Y. S. Kim, D. Baran, and V. J. Dzau An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro Am J Physiol Renal Physiol, August 1, 1998; 275(2): F278 - F284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Slack, H. El-Bizri, J. Wong, D. J. Belliveau, and F. D. Miller A Critical Temporal Requirement for the Retinoblastoma Protein Family During Neuronal Determination J. Cell Biol., March 23, 1998; 140(6): 1497 - 1509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R K Hurford, D Cobrinik, M H Lee, and N Dyson pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes & Dev., June 1, 1997; 11(11): 1447 - 1463. [Abstract] [PDF]
|
|
|
|
|
|
M. C. Birchenall-Roberts, Y. D. Yoo, D. C. Bertolette III, K.-H. Lee, J. M. Turley, O.-S. Bang, F. W. Ruscetti, and S.-J. Kim The p120-v-Abl Protein Interacts with E2F-1 and Regulates E2F-1 Transcriptional Activity J. Biol. Chem., April 4, 1997; 272(14): 8905 - 8911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pullner, J. Mautner, T. Albert, and D. Eick Nucleosomal Structure of Active and Inactive c-myc Genes J. Biol. Chem., December 6, 1996; 271(49): 31452 - 31457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, J. Campisi, and R. Padmanabhan SV40 Large T Antigen Transactivates the Human cdc2 Promoter by Inducing a CCAAT Box Binding Factor J. Biol. Chem., June 14, 1996; 271(24): 13959 - 13967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Vairo, D M Livingston, and D Ginsberg Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes & Dev., April 1, 1995; 9(7): 869 - 881. [Abstract] [PDF]
|
|
|
|
|
|
A Krumm, L B Hickey, and M Groudine Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation. Genes & Dev., March 1, 1995; 9(5): 559 - 572. [Abstract] [PDF]
|
|
|
|
|
|
D Ginsberg, G Vairo, T Chittenden, Z X Xiao, G Xu, K L Wydner, J A DeCaprio, J B Lawrence, and D M Livingston E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes & Dev., November 15, 1994; 8(22): 2665 - 2679. [Abstract] [PDF]
|
|
|
|
|
|
B D Dynlacht, O Flores, J A Lees, and E Harlow Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes & Dev., August 1, 1994; 8(15): 1772 - 1786. [Abstract] [PDF]
|
|
|
|
|
|
D Cobrinik, P Whyte, D S Peeper, T Jacks, and R A Weinberg Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes & Dev., December 1, 1993; 7(12a): 2392 - 2404. [Abstract] [PDF]
|
|
|
|
|
|
K Helin, C L Wu, A R Fattaey, J A Lees, B D Dynlacht, C Ngwu, and E Harlow Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes & Dev., October 1, 1993; 7(10): 1850 - 1861. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Friend Genetic models for studying cancer susceptibility Science, February 5, 1993; 259(5096): 774 - 775. [PDF]
|
|
|
|
|
|
Nevins JR E2F: a link between the Rb tumor suppressor protein and viral oncoproteins Science, October 16, 1992; 258(5081): 424 - 429. [Abstract] [PDF]
|
|
|
|
|
|
M M Huang and P Hearing The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex. Genes & Dev., November 1, 1989; 3(11): 1699 - 1710. [Abstract] [PDF]
|
|
