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GENES & DEVELOPMENT 22:1572-1576, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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A matter of timing: microRNA-controlled temporal identities in worms and flies

Manfred Frasch1

Department Biology, Developmental Biology Unit, University of Erlangen-Nürnberg, Erlangen, 91058 Erlangen, Germany

The first microRNAs were identified in Caenorhabditis elegans based on their functions in the temporal regulation of stage-specific cell fate decisions. Until now, it was not known whether the so-called heterochronic genes that encode miRNAs are also involved in controlling developmental transitions in other organisms. New findings by Sokol et al. (this issue of Genes & Development, pp. 1591–1596) demonstrate that the Drosophila counterpart of a heterochronic miRNA gene from C. elegans, let-7, does indeed play a role in promoting stage-specific developmental events in neuromuscular tissues during the transition from larval to adult stages, thus pointing to a more widespread utilization of miRNAs in temporal regulation of animal development.

[Keywords: let-7; let-7-Complex; microRNA; heterochronic; developmental timing; neuromuscular junction]

1 Correspondence.

E-MAIL manfred.frasch{at}biologie.uni-erlangen.de; FAX 49-9131-8528040.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1690608.


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Related Article

Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis
Nicholas S. Sokol, Peizhang Xu, Yuh-Nung Jan, and Victor Ambros
Genes & Dev. 2008 22: 1591-1596. [Abstract] [Full Text] [PDF]





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