Genes and Development

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GENES & DEVELOPMENT 22:1567-1571, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis

Miguel R. Branco, Masaaki Oda, and Wolf Reik1

Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, United Kingdom

During early mammalian embryogenesis, the genome undergoes global epigenetic reprogramming, losing most of its methylation before re-establishing it de novo at implantation. However, faithful maintenance of methylation at imprinted genes during this process is vital for embryonic development, but the DNA methyltransferase responsible for this maintenance has remained unknown. In this issue of Genes & Development, Hirasawa and colleagues (pp. 1607–1616) show that Dnmt1, and not Dnmt3a or Dnmt3b, maintains methylation at genomic imprints during preimplantation development.

[Keywords: Genomic imprinting; DNA methylation; pre-implantation embryos; Dnmt1]

1 Corresponding author.

E-MAIL wolf.reik{at}bbsrc.ac.uk; FAX 44 1223 496015.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1690508.


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Related Article

Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development
Ryutaro Hirasawa, Hatsune Chiba, Masahiro Kaneda, Shoji Tajima, En Li, Rudolf Jaenisch, and Hiroyuki Sasaki
Genes & Dev. 2008 22: 1607-1616. [Abstract] [Full Text] [PDF]





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