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Intriguing parasites and intramembrane proteases

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA

Rhomboid intramembrane proteases occur throughout the kingdoms of life. In this issue of Genes & Development, Baxt and colleagues (pp. 1636–1646) report that the single proteolytic rhomboid (EhROM1) from Entamoeba histolytica cleaves cell surface galactose-binding or N-acetylgalactosamine-binding (Gal/Gal-NAc) lectins. EhROM1 and lectins colocalize during phagocytosis and receptor capping. EhROM1 is found at the base of the cap rather than in the cap proper, suggesting a role in receptor shedding and implying that EhROM1 is crucial for amoebal infection.

[Keywords: Serine protease; presenilin; site-2 protease; erythrophagocytosis; immune evasion; pathogenesis]

E-MAIL Rob.Rawson{at}UTSouthwestern.Edu; FAX (214) 648-8804.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1686808.

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An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion

Leigh A. Baxt, Rosanna P. Baker, Upinder Singh, and Sinisa Urban
Genes & Dev. 2008 22: 1636-1646. [Abstract] [Full Text] [PDF]