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GENES & DEVELOPMENT 21:750-755, 2007
©2007 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH COMMUNICATION

Two small regulatory RNAs establish opposing fates of a developmental axis

Fabio T.S. Nogueira1,3, Shahinez Madi1,3, Daniel H. Chitwood1,2, Michelle T. Juarez1,4, and Marja C.P. Timmermans1,2,5

1 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; 2 Watson School of Biological Sciences, Cold Spring Harbor, New York 11724, USA

Small RNAs are important regulators of gene expression. In maize, adaxial/abaxial (dorsoventral) leaf polarity is established by an abaxial gradient of microRNA166 (miR166), which spatially restricts the expression domain of class III homeodomain leucine zipper (HD-ZIPIII) transcription factors that specify adaxial/upper fate. Here, we show that leafbladeless1 encodes a key component in the trans-acting small interfering RNA (ta-siRNA) biogenesis pathway that acts on the adaxial side of developing leaves and demarcates the domains of hd-zipIII and miR166 accumulation. Our findings indicate that tasiR-ARF, a ta-siRNA, and miR166 establish opposing domains along the adaxial–abaxial axis, thus revealing a novel mechanism of pattern formation.

[Keywords: Meristem; leaf; polarity; pattern formation; microRNA; trans-acting siRNA]

Received January 8, 2007; revised version accepted February 20, 2007.

3 These authors contributed equally to this work.

4 Present address: Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

5 Corresponding author.

E-MAIL timmerma{at}cshl.edu; FAX (516) 367-8369.

Supplemental material is available at www.genesdev.org.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1528607


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