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RESEARCH COMMUNICATION
1 Plant Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA; 2 Howard Hughes Medical Institute Plant Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA; 3 Zentrum für Molekularbiologie der Pflanzen, 72076 Tübingen, Germany
The LRR receptor serine/threonine kinases are a major eukaryotic receptor family, for which the central regulatory mechanism of endosomal trafficking remains largely unadressed. We show that the steroid receptor BRI1 localizes to both plasma membrane and early endosomal compartments, even when observed at low, endogenous expression levels, and that its localization and turnover are independent of ligand. However, increasing endosomal localization of BRI1 enhances activation of the pathway and genomic responses. Our data indicate distinct signaling and trafficking mechanisms within this receptor class and show that the use of endosomes as signaling compartments is an unexpectedly broad phenomenon in eukaryotes.
[Keywords: Brassinosteroid; endosomes; plant receptor kinase; Arabidopsis; receptor trafficking]
Received April 12, 2007; revised version accepted May 16, 2007.
E-MAIL chory{at}salk.edu; FAX (858) 558-6379.
Supplemental material is available at http://www.genesdev.org.
Article published online ahead of print. Article and publication date are online at http://www.genesdev.org/cgi/doi/10.1101/gad.1561307
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Genes & Dev. 2007 21: 1578-1580.
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