Genes and Development

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

GENES & DEVELOPMENT 21:1484-1493, 2007
©2007 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Research Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Palma, K.
Right arrow Articles by Li, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Palma, K.
Right arrow Articles by Li, X.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms

Kristoffer Palma1,2, Qingguo Zhao3, Yu Ti Cheng1,2, Dongling Bi3, Jacqueline Monaghan1,4, Wei Cheng3, Yuelin Zhang3, and Xin Li1,4,5

1 Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada; 2 Genetics Graduate Program, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada; 3 National Institute of Biological Sciences (NIBS), Zhongguancun Life Science Park, Beijing 102206, People’s Republic of China; 4 Department of Botany, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

Innate immunity against pathogen infection is an evolutionarily conserved process among multicellular organisms. Arabidopsis SNC1 encodes a Resistance protein that combines attributes of multiple mammalian pattern recognition receptors. Utilizing snc1 as an autoimmune model, we identified a discrete protein complex containing at least three members—MOS4 (Modifier Of snc1, 4), AtCDC5, and PRL1 (Pleiotropic Regulatory Locus 1)—that are all essential for plant innate immunity. AtCDC5 has DNA-binding activity, suggesting that this complex probably regulates defense responses through transcriptional control. Since the complex components along with their interactions are highly conserved from fission yeast to Arabidopsis and human, they may also have a yet-to-be-identified function in mammalian innate immunity.

[Keywords: Innate immunity; Arabidopsis; MOS4; PRL1; AtCDC5; NTC; MAC]

Received April 9, 2007; revised version accepted April 30, 2007.

5 Corresponding author.

E-MAIL xinli{at}interchange.ubc.ca; FAX (604) 822-2114.

Supplemental material is available at http://www.genesdev.org.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1559607


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Plant Physiol.Home page
S. Goritschnig, T. Weihmann, Y. Zhang, P. Fobert, P. McCourt, and X. Li
A Novel Role for Protein Farnesylation in Plant Innate Immunity
Plant Physiology, September 1, 2008; 148(1): 348 - 357.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genome Res. Learn. Mem.
Protein Science RNA Genes Dev.
Copyright © 2007 by Cold Spring Harbor Laboratory Press.