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GENES & DEVELOPMENT 21:1322-1327, 2007
©2007 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH COMMUNICATION

Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers

Alena Krejcí and Sarah Bray1

Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom

The CSL [CBF1/Su(H)/Lag2] proteins [Su(H) in Drosophila] are implicated in repression and activation of Notch target loci. Prevailing models imply a static association of these DNA-binding transcription factors with their target enhancers. Our analysis of Su(H) binding and chromatin-associated features at 11 E(spl) Notch target genes before and after Notch revealed large differences in Su(H) occupancy at target loci that correlated with the presence of polymerase II and other marks of transcriptional activity. Unexpectedly, Su(H) occupancy was significantly and transiently increased following Notch activation, suggesting a more dynamic interaction with targets than hitherto proposed.

[Keywords: Notch; chromatin; developmental signaling; transcription factor; CSL proteins; E(spl) complex]

Received January 10, 2007; revised version accepted April 12, 2007.

1 Corresponding author.

E-MAIL sjb32{at}cam.ac.uk; FAX 44-1223-333840.

Supplemental material is available at http://www.genesdev.org.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.424607


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