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REVIEW

CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling

Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom

Multiple members of the casein kinase I family of serine/threonine protein kinases are involved in positive and negative roles in Wnt and Hedgehog signaling. Here I review these roles, including recent results on casein kinase I (CKI) phosphorylation and activation of LRP6, and CKI phosphorylation of Ci and mediation of Ci–Slimb/–TrCP binding.

[Keywords: Casein kinase I; Wnt signaling; Hedgehog signaling]

¹ Correspondence.

E-MAIL m.a.price{at}sheffield.ac.uk; FAX 44-0-114 276-5413.

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