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GENES & DEVELOPMENT 20:380-389, 2006
©2006 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH PAPER

Drosophila UNR is required for translational repression of male-specific lethal 2 mRNA during regulation of X-chromosome dosage compensation

Irina Abaza, Olga Coll, Solenn Patalano and Fátima Gebauer1

Centre de Regulació Genómica (CRG-UPF), 08003 Barcelona, Spain

The inhibition of male-specific lethal 2 (msl-2) mRNA translation by the RNA-binding protein sex-lethal (SXL) is an essential regulatory step for X-chromosome dosage compensation in Drosophila melanogaster. The mammalian upstream of N-ras (UNR) protein has been implicated in the regulation of mRNA stability and internal ribosome entry site (IRES)-dependent mRNA translation. Here we have identified the Drosophila homolog of mammalian UNR as a cofactor required for SXL-mediated repression of msl-2 translation. UNR interacts with SXL, a female-specific protein. Although UNR is present in both male and female flies, binding of SXL to uridine-rich sequences in the 3' untranslated region (UTR) of msl-2 mRNA recruits UNR to adjacent regulatory sequences, thereby conferring a sex-specific function to UNR. These data identify a novel regulator of dosage compensation in Drosophila that acts coordinately with SXL in translational control.

[Keywords: msl-2; SXL; UNR; dosage compensation; translational control]

Received October 31, 2005; revised version accepted December 7, 2005.

Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.371906.

1 Corresponding author.

E-MAIL fatima.gebauer{at}crg.es; FAX 0034-93-2240899.


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