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REVIEW

Modulating the outer membrane with small RNAs

¹ Laboratory of Molecular Biology, National Cancer Institute, Bethesda 20892, Maryland, USA; ² Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda 20892, Maryland, USA

MicF, one of the first chromosomally encoded regulatory small RNAs (sRNAs) to be discovered, was found to modulate the expression of OmpF, an abundant outer membrane protein. Several recent papers have now shown that this is not an isolated case. At least five other sRNAs also regulate the synthesis of outer membrane porins, and additional sRNAs modulate the expression of other outer membrane proteins. Here we review what is known about these sRNAs and discuss the implications of this regulation.

[Keywords: Hfq; OmpC; OmpA; ^E; OmpR]

³ E-MAIL susang{at}helix.nih.gov; FAX (301) 496-3875.

⁴ E-MAIL storz{at}helix.nih.gov; FAX (301) 402-0078.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1457506.

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