QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Research Data Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Szeto, D. P. Articles by Kimelman, D. Search for Related Content PubMed PubMed Citation Articles by Szeto, D. P. Articles by Kimelman, D. Related Content Related Article Social Bookmarking                   What's this?

The regulation of mesodermal progenitor cell commitment to somitogenesis subdivides the zebrafish body musculature into distinct domains

Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA

The vertebrate musculature is produced from a visually uniform population of mesodermal progenitor cells (MPCs) that progressively bud off somites populating the trunk and tail. How the MPCs are regulated to continuously release cells into the presomitic mesoderm throughout somitogenesis is not understood. Using a genetic approach to study the MPCs, we show that a subset of MPCs are set aside very early in zebrafish development, and programmed to cell-autonomously enter the tail domain beginning with the 16th somite. Moreover, we show that the trunk is subdivided into two domains, and that entry into the anterior trunk, posterior trunk, and tail is regulated by interactions between the Nodal and bone morphogenetic protein (Bmp) pathways. Finally, we show that the tail MPCs are held in a state we previously called the Maturation Zone as they wait for the signal to begin entering somitogenesis.

[Keywords: Bmp signaling; Nodal; T-box genes; MZoep; somite]

Received March 29, 2006; revised version accepted May 12, 2006.

² Corresponding author.

E-MAIL kimelman{at}u.washington.edu; FAX (206) 616-8676.

Supplemental material is available at http://www.genesdev.org.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1435306

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

Anterior–posterior differences in vertebrate segments: specification of trunk and tail somites in the zebrafish blastula

Scott A. Holley
Genes & Dev. 2006 20: 1831-1837. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				S. Elworthy, M. Hargrave, R. Knight, K. Mebus, and P. W. Ingham Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity Development, June 15, 2008; 135(12): 2115 - 2126. [Abstract] [Full Text] [PDF]

				E. T. Shifley, K. M. VanHorn, A. Perez-Balaguer, J. D. Franklin, M. Weinstein, and S. E. Cole Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton Development, March 1, 2008; 135(5): 899 - 908. [Abstract] [Full Text] [PDF]