![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
Abstract
One of the elements that mediates growth factor and serum inducibility of the human c-fos gene is a region of dyad symmetry that lies between nucleotides -320 and -299 of the human gene. A mammalian protein specifically binds to this sequence element and has been termed the serum response factor (SRF). Gel-shift analysis and competition experiments demonstrate that there is a factor in the yeast Saccharomyces cerevisiae that binds specifically to the human c-fos SRE. The methylation interference pattern of the yeast factor is identical to that of the mammalian SRF. Regulatory elements of cell-type-specific genes in yeast have homologies to the c-fos SRE and complete for binding of both the mammalian and yeast factors to the SRE. Antisera to the gene product of the MCM1 locus react with the yeast SRE-binding factor. These data suggest that this yeast protein is closely related or identical to the factors [general regulator of mating type (GRM) and pheromone/receptor transcription factor (PRTF)] that are required for the regulation of cell-type-specific genes in yeast.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  I.-H. Kang, J. G. Steffen, M. F. Portereiko, A. Lloyd, and G. N. Drews The AGL62 MADS Domain Protein Regulates Cellularization during Endosperm Development in Arabidopsis PLANT CELL, March 1, 2008; 20(3): 635 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Verelst, H. Saedler, and T. Munster MIKC* MADS-Protein Complexes Bind Motifs Enriched in the Proximal Region of Late Pollen-Specific Arabidopsis Promoters Plant Physiology, January 1, 2007; 143(1): 447 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ciannamea, K. Kaufmann, M. Frau, I. A. N. Tonaco, K. Petersen, K. K. Nielsen, G. C. Angenent, and R. G. H. Immink Protein interactions of MADS box transcription factors involved in flowering in Lolium perenne J. Exp. Bot., October 1, 2006; 57(13): 3419 - 3431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Portereiko, A. Lloyd, J. G. Steffen, J. A. Punwani, D. Otsuga, and G. N. Drews AGL80 Is Required for Central Cell and Endosperm Development in Arabidopsis PLANT CELL, August 1, 2006; 18(8): 1862 - 1872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. X. Zhang, E. Garcia-Gras, D. R. Wycuff, S. J. Marriot, N. Kadeer, W. Yu, E. N. Olson, D. J. Garry, M. S. Parmacek, and R. J. Schwartz Identification of Direct Serum-response Factor Gene Targets during Me2SO-induced P19 Cardiac Cell Differentiation J. Biol. Chem., May 13, 2005; 280(19): 19115 - 19126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Parenicova, S. de Folter, M. Kieffer, D. S. Horner, C. Favalli, J. Busscher, H. E. Cook, R. M. Ingram, M. M. Kater, B. Davies, et al. Molecular and Phylogenetic Analyses of the Complete MADS-Box Transcription Factor Family in Arabidopsis: New Openings to the MADS World PLANT CELL, July 1, 2003; 15(7): 1538 - 1551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Hollenhorst, G. Pietz, and C. A. Fox Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation Genes & Dev., September 15, 2001; 15(18): 2445 - 2456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-W. Kim, V. Cheriyath, A. L. Roy, and B. H. Cochran TFII-I Enhances Activation of the c-fos Promoter through Interactions with Upstream Elements Mol. Cell. Biol., June 1, 1998; 18(6): 3310 - 3320. [Abstract] [Full Text]
|
|
|
|
|
|
Y T Yu, R E Breitbart, L B Smoot, Y Lee, V Mahdavi, and B Nadal-Ginard Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes & Dev., September 1, 1992; 6(9): 1783 - 1798. [Abstract] [PDF]
|
|
|
|
|
|
R Pollock and R Treisman Human SRF-related proteins: DNA-binding properties and potential regulatory targets. Genes & Dev., December 1, 1991; 5(12a): 2327 - 2341. [Abstract] [PDF]
|
|
|
|
|
|
P Sengupta and B H Cochran MAT alpha 1 can mediate gene activation by a-mating factor. Genes & Dev., October 1, 1991; 5(10): 1924 - 1934. [Abstract] [PDF]
|
|
|
|
 |
|
 R Graham and M Gilman Distinct protein targets for signals acting at the c-fos serum response element Science, January 11, 1991; 251(4990): 189 - 192. [Abstract] [PDF]
|
|
|
|
|
|
J W Dolan and S Fields Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction. Genes & Dev., April 1, 1990; 4(4): 492 - 502. [Abstract] [PDF]
|
|
|
|
|
|
V M Rivera, M Sheng, and M E Greenberg The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation. Genes & Dev., February 1, 1990; 4(2): 255 - 268. [Abstract] [PDF]
|
|
|
|
|
|
G Ammerer Identification, purification, and cloning of a polypeptide (PRTF/GRM) that binds to mating-specific promoter elements in yeast. Genes & Dev., February 1, 1990; 4(2): 299 - 312. [Abstract] [PDF]
|
|
|
|
|
|
B Errede and G Ammerer STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes & Dev., September 1, 1989; 3(9): 1349 - 1361. [Abstract] [PDF]
|
|
|
|
|
|
S Passmore, R Elble, and B K Tye A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes. Genes & Dev., July 1, 1989; 3(7): 921 - 935. [Abstract] [PDF]
|
|
|
|
|
|
E E Jarvis, K L Clark, and G F Sprague The yeast transcription activator PRTF, a homolog of the mammalian serum response factor, is encoded by the MCM1 gene. Genes & Dev., July 1, 1989; 3(7): 936 - 945. [Abstract] [PDF]
|
|
