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RESEARCH COMMUNICATION
1 Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA; 2 Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, New York 10016, USA; 3 The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Radial glia function during CNS development both as neural progenitors and as a scaffolding supporting neuronal migration. To elucidate pathways involved in these functions, we mapped in vivo the promoter for Blbp, a radial glial gene. We show here that a binding site for the Notch effector CBF1 is essential for all Blbp transcription in radial glia, and that BLBP expression is significantly reduced in the forebrains of mice lacking the Notch1 and Notch3 receptors. These results identify Blbp as the first predominantly CNS-specific Notch target gene and suggest that it mediates some aspects of Notch signaling in radial glia.
[Keywords: Neuronal–glial interactions; cortex; cerebellum; Bergmann glia]
Received February 2, 2005; revised version accepted March 25, 2005.
E-MAIL heintz{at}rockefeller.edu; FAX (212) 327-7878.
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