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Published online before print January 28, 2005, 10.1101/gad.1278205
GENES & DEVELOPMENT 19:419-424, 2005
©2005 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH COMMUNICATION

The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis

Mark Rosenzweig1, Karen M. Brennan1, Timothy D. Tayler1, Paul O. Phelps1, Ardem Patapoutian2,3 and Paul A. Garrity1,4

1 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; 2 Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA; 3 Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA

Thermotaxis is important for animal survival, but the molecular identities of temperature sensors controlling this behavior have not been determined. We demonstrate dTRPA1, a heat-activated Transient Receptor Potential (TRP) family ion channel, is essential for thermotaxis in Drosophila. dTrpA1 knockdown eliminates avoidance of elevated temperatures along a thermal gradient. We observe dTRPA1 expression in cells without previously ascribed roles in thermosensation and implicate dTRPA1-expressing neurons in mediating thermotaxis. Our data suggest that thermotaxis relies upon neurons and molecules distinct from those required for high-temperature nociception. We propose dTRPA1 may control thermotaxis by sensing environmental temperature.

[Keywords: Thermosensation; thermotactic behavior; dTRPA1; ANKTM1; nociception]

Received November 3, 2004; revised version accepted December 21, 2004.

Supplemental material is available at http://www.genesdev.org.

Article published online ahead of print. Article and publication date are at http://www.genesdev.org/cgi/doi/10.1101/gad.1278205.

4 Corresponding author.

E-MAIL pgarrity{at}mit.edu; FAX (617) 258-3128.


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