QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Research Data Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Prochasson, P. Articles by Workman, J. L. Search for Related Content PubMed PubMed Citation Articles by Prochasson, P. Articles by Workman, J. L. Social Bookmarking                   What's this?

RESEARCH COMMUNICATION

The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF

The Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA

The histone regulatory (HIR) and histone promoter control (HPC) repressor proteins regulate three of the four histone gene loci during the Saccharomyces cerevisiae cell cycle. Here, we demonstrate that Hir1, Hir2, Hir3, and Hpc2 proteins form a stable HIR repressor complex. The HIR complex promotes histone deposition onto DNA in vitro and constitutes a novel nucleosome assembly complex. The HIR complex stably binds to DNA and nucleosomes. Furthermore, HIR complex binding to nucleosomes forms a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Thus, the HIR complex is a novel nucleosome assembly complex which functions with SWI/SNF to regulate transcription.

[Keywords: HIR; HPC; SWI/SNF; nucleosome remodeling; histone; HIRA]

Received June 7, 2005; revised version accepted September 8, 2005.

Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1341105.

¹ Corresponding author.
E-MAIL jlw{at}stowers-institute.org; FAX (816) 926-4692.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. Biswas, S. Takahata, H. Xin, R. Dutta-Biswas, Y. Yu, T. Formosa, and D. J. Stillman A Role for Chd1 and Set2 in Negatively Regulating DNA Replication in Saccharomyces cerevisiae Genetics, February 1, 2008; 178(2): 649 - 659. [Abstract] [Full Text] [PDF]

				X. Ye, B. Zerlanko, R. Zhang, N. Somaiah, M. Lipinski, P. Salomoni, and P. D. Adams Definition of pRB- and p53-Dependent and -Independent Steps in HIRA/ASF1a-Mediated Formation of Senescence-Associated Heterochromatin Foci Mol. Cell. Biol., April 1, 2007; 27(7): 2452 - 2465. [Abstract] [Full Text] [PDF]

				G. Mendiratta, P. R. Eriksson, and D. J. Clark Cooperative binding of the yeast Spt10p activator to the histone upstream activating sequences is mediated through an N-terminal dimerization domain Nucleic Acids Res., February 16, 2007; 35(3): 812 - 821. [Abstract] [Full Text] [PDF]

				J. Recht, T. Tsubota, J. C. Tanny, R. L. Diaz, J. M. Berger, X. Zhang, B. A. Garcia, J. Shabanowitz, A. L. Burlingame, D. F. Hunt, et al. Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis PNAS, May 2, 2006; 103(18): 6988 - 6993. [Abstract] [Full Text] [PDF]

				A. Greenall, E. S. Williams, K. A. Martin, J. M. Palmer, J. Gray, C. Liu, and S. K. Whitehall Hip3 Interacts with the HIRA Proteins Hip1 and Slm9 and Is Required for Transcriptional Silencing and Accurate Chromosome Segregation J. Biol. Chem., March 31, 2006; 281(13): 8732 - 8739. [Abstract] [Full Text] [PDF]

				A. Nourani, F. Robert, and F. Winston Evidence that Spt2/Sin1, an HMG-Like Factor, Plays Roles in Transcription Elongation, Chromatin Structure, and Genome Stability in Saccharomyces cerevisiae Mol. Cell. Biol., February 15, 2006; 26(4): 1496 - 1509. [Abstract] [Full Text] [PDF]