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GENES & DEVELOPMENT 19:2418-2423, 2005
©2005 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH COMMUNICATION

A core promoter element downstream of the TATA box that is recognized by TFIIB

Wensheng Deng and Stefan G.E. Roberts1

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom

We have defined a core promoter element downstream of the TATA box that is recognized by TFIIB. This involves a DNA-binding domain in TFIIB that is distinct from the helix–turn–helix motif (which recognizes an element upstream of the TATA box). The TFIIB recognition element we describe regulates transcription in a manner that is promoter context-dependent, particularly with respect to the TFIIB recognition element that is located upstream of the TATA box. Thus TFIIB can recognize two distinct sequence elements that flank the TATA box, employing independent DNA-binding motifs and cooperating in the regulation of transcription.

[Keywords: Transcription; RNA polymerase II; TFIIB; promoter]

Received March 6, 2005; revised version accepted August 16, 2005.

Supplemental material is available at http://www.genesdev.org.

Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.342405.

1 Corresponding author.

E-MAIL stefan.roberts{at}manchester.ac.uk; FAX 0161-275-5082.


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