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GENES & DEVELOPMENT 19:1743-1748, 2005
©2005 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH COMMUNICATION

Asymmetric cortical and nuclear localizations of WRM-1/{beta}-catenin during asymmetric cell division in C. elegans

Hisako Takeshita1 and Hitoshi Sawa1,2,3

1 Laboratory for Cell Fate Decision, Riken, Center for Developmental Biology, Kobe 650-0047, Japan; 2 Division of Bioinformation, Department of Biosystems Science, Graduate School of Science and Technology, Kobe University, Kobe 650-0017, Japan

{beta}-Catenin can promote adhesion at the cell cortex and mediate Wnt signaling in the nucleus. We show that, in Caenorhabditis elegans, both WRM-1/{beta}-catenin and LIT-1 kinase localize to the anterior cell cortex during asymmetric cell division but to the nucleus of the posterior daughter afterward. Both the cortical and nuclear localizations are regulated by Wnts and are apparently coupled. We also found that the daughters show different nuclear export rates for LIT-1. Our results indicate that Wnt signals release cortical WRM-1 from the posterior cortex to generate cortical asymmetry that may control WRM-1 asymmetric nuclear localization by regulating cell polarity.

[Keywords: Wnt; {beta}-catenin; WRM-1; cell polarity; asymmetric cell division; C. elegans]

Received April 11, 2005; revised version accepted June 3, 2005.

Supplemental material is available at htttp://www.genesdev.org.

Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1322805.

3 Corresponding author.
E-MAIL sawa{at}cdb.riken.jp; FAX 81-78-306-3200.


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