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GENES & DEVELOPMENT 19:1156-1161, 2005
©2005 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH COMMUNICATION

Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites

Akinori Kawamura1,6, Sumito Koshida1,2,3,6, Hiroko Hijikata3, Takuya Sakaguchi4, Hisato Kondoh3,5 and Shinji Takada1,2,3,7

1 Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan; 2 Department of Molecular Biomechanics, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8787, Japan; 3 Kondoh Differentiation Signaling Project, Exploratory Research for Advanced Technology (ERATO)/SORST Program, Kondoh Research Team, Japan Science and Technology Corporation (JST), Kinki Invention Center, Sakyo-ku, Kyoto 606-8305, Japan; 4 Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94143, USA; 5 Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan

Notch and fibroblast growth factor (FGF) signaling pathways have been implicated in the establishment of proper periodicity of vertebrate somites. Here, we show evidence that a Hes6-related hairy/Enhancer of split-related gene, her13.2, links FGF signaling to the Notch-regulated oscillation machinery in zebrafish. Expression of her13.2 is induced by FGF-soaked beads and decreased by an FGF signaling inhibitor. her13.2 is required for periodic repression of the Notch-regulated genes her1 and her7, and for proper somite segmentation. Furthermore, Her13.2 augments autorepression of her1 in association with Her1 protein. Therefore, FGF signaling appears to maintain the oscillation machinery by supplying a binding partner, Her13.2, for Her1.

[Keywords: Somite segmentation; FGF signaling; cyclic gene expression; hairy/Espl; negative feedback loop; zebrafish]

Received December 17, 2004; revised version accepted March 31, 2005.

Supplemental material is available at http://www.genesdev.org.

Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1291205.

6 These authors contributed equally to this work.

7 Corresponding author.

E-MAIL stakada{at}nibb.ac.jp; FAX 81-564-59-5240.


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