![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
RESEARCH PAPER
1 Division of Molecular Microbiology, 2 Department of Chemistry, and 3 Division of Structural Biology, Biozentrum, University of Basel, 4056 Basel, Switzerland
Pole development is coordinated with the Caulobacter crescentus cell cycle by two-component signaling proteins. We show that an unusual response regulator, PleD, is required for polar differentiation and is sequestered to the cell pole only when it is activated by phosphorylation. Dynamic localization of PleD to the cell pole provides a mechanism to temporally and spatially control the signaling output of PleD during development. Targeting of PleD to the cell pole is coupled to the activation of a C-terminal guanylate cyclase domain, which catalyzes the synthesis of cyclic di-guanosine monophosphate. We propose that the local action of this novel-type guanylate cyclase might constitute a general regulatory principle in bacterial growth and development.
[Keywords: Caulobacter development; GGDEF domain; protein localization; response regulator]
Received October 28, 2003; revised version accepted February 5, 2004.
4 Corresponding author.
E-MAIL urs.jenal{at}unibas.ch; FAX 41-61-267-2118.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  L. M. Holland, S. T. O'Donnell, D. A. Ryjenkov, L. Gomelsky, S. R. Slater, P. D. Fey, M. Gomelsky, and J. P. O'Gara A Staphylococcal GGDEF Domain Protein Regulates Biofilm Formation Independently of Cyclic Dimeric GMP J. Bacteriol., August 1, 2008; 190(15): 5178 - 5189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gualdi, L. Tagliabue, S. Bertagnoli, T. Ierano, C. De Castro, and P. Landini Cellulose modulates biofilm formation by counteracting curli-mediated colonization of solid surfaces in Escherichia coli Microbiology, July 1, 2008; 154(7): 2017 - 2024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nakhamchik, C. Wilde, and D. A. Rowe-Magnus Cyclic-di-GMP Regulates Extracellular Polysaccharide Production, Biofilm Formation, and Rugose Colony Development by Vibrio vulnificus Appl. Envir. Microbiol., July 1, 2008; 74(13): 4199 - 4209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Tamayo, S. Schild, J. T. Pratt, and A. Camilli Role of Cyclic Di-GMP during El Tor Biotype Vibrio cholerae Infection: Characterization of the In Vivo-Induced Cyclic Di-GMP Phosphodiesterase CdpA Infect. Immun., April 1, 2008; 76(4): 1617 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. R. Ferreira, L. C. M. Antunes, E. P. Greenberg, and L. L. McCarter Vibrio parahaemolyticus ScrC Modulates Cyclic Dimeric GMP Regulation of Gene Expression Relevant to Growth on Surfaces J. Bacteriol., February 1, 2008; 190(3): 851 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Wolfe and K. L. Visick Get the Message Out: Cyclic-Di-GMP Regulates Multiple Levels of Flagellum-Based Motility J. Bacteriol., January 15, 2008; 190(2): 463 - 475. [Full Text] [PDF]
|
|
|
|
|
|
J. H. Merritt, K. M. Brothers, S. L. Kuchma, and G. A. O'Toole SadC Reciprocally Influences Biofilm Formation and Swarming Motility via Modulation of Exopolysaccharide Production and Flagellar Function J. Bacteriol., November 15, 2007; 189(22): 8154 - 8164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Kuchma, K. M. Brothers, J. H. Merritt, N. T. Liberati, F. M. Ausubel, and G. A. O'Toole BifA, a Cyclic-Di-GMP Phosphodiesterase, Inversely Regulates Biofilm Formation and Swarming Motility by Pseudomonas aeruginosa PA14 J. Bacteriol., November 15, 2007; 189(22): 8165 - 8178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gualdi, L. Tagliabue, and P. Landini Biofilm Formation-Gene Expression Relay System in Escherichia coli: Modulation of {sigma}S-Dependent Gene Expression by the CsgD Regulatory Protein via {sigma}S Protein Stabilization J. Bacteriol., November 15, 2007; 189(22): 8034 - 8043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Fineran, N. R. Williamson, K. S. Lilley, and G. P. C. Salmond Virulence and Prodigiosin Antibiotic Biosynthesis in Serratia Are Regulated Pleiotropically by the GGDEF/EAL Domain Protein, PigX J. Bacteriol., November 1, 2007; 189(21): 7653 - 7662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Paul, S. Abel, P. Wassmann, A. Beck, H. Heerklotz, and U. Jenal Activation of the Diguanylate Cyclase PleD by Phosphorylation-mediated Dimerization J. Biol. Chem., October 5, 2007; 282(40): 29170 - 29177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-K. Kim and L. L. McCarter ScrG, a GGDEF-EAL Protein, Participates in Regulating Swarming and Sticking in Vibrio parahaemolyticus J. Bacteriol., June 1, 2007; 189(11): 4094 - 4107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Simm, A. Lusch, A. Kader, M. Andersson, and U. Romling Role of EAL-Containing Proteins in Multicellular Behavior of Salmonella enterica Serovar Typhimurium J. Bacteriol., May 1, 2007; 189(9): 3613 - 3623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Pratt, R. Tamayo, A. D. Tischler, and A. Camilli PilZ Domain Proteins Bind Cyclic Diguanylate and Regulate Diverse Processes in Vibrio cholerae J. Biol. Chem., April 27, 2007; 282(17): 12860 - 12870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Malone, R. Williams, M. Christen, U. Jenal, A. J. Spiers, and P. B. Rainey The structure-function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain Microbiology, April 1, 2007; 153(4): 980 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Christen, B. Christen, M. G. Allan, M. Folcher, P. Jeno, S. Grzesiek, and U. Jenal DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus PNAS, March 6, 2007; 104(10): 4112 - 4117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lim, S. Beyhan, and F. H. Yildiz Regulation of Vibrio Polysaccharide Synthesis and Virulence Factor Production by CdgC, a GGDEF-EAL Domain Protein, in Vibrio cholerae J. Bacteriol., February 1, 2007; 189(3): 717 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Ryan, Y. Fouhy, J. F. Lucey, and J. M. Dow Cyclic Di-GMP Signaling in Bacteria: Recent Advances and New Puzzles J. Bacteriol., December 15, 2006; 188(24): 8327 - 8334. [Full Text] [PDF]
|
|
|
|
|
|
T. M. O'Shea, A. H. Klein, K. Geszvain, A. J. Wolfe, and K. L. Visick Diguanylate Cyclases Control Magnesium-Dependent Motility of Vibrio fischeri J. Bacteriol., December 1, 2006; 188(23): 8196 - 8205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tarutina, D. A. Ryjenkov, and M. Gomelsky An Unorthodox Bacteriophytochrome from Rhodobacter sphaeroides Involved in Turnover of the Second Messenger c-di-GMP J. Biol. Chem., November 17, 2006; 281(46): 34751 - 34758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Christen, M. Christen, R. Paul, F. Schmid, M. Folcher, P. Jenoe, M. Meuwly, and U. Jenal Allosteric Control of Cyclic di-GMP Signaling J. Biol. Chem., October 20, 2006; 281(42): 32015 - 32024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Ryjenkov, R. Simm, U. Romling, and M. Gomelsky The PilZ Domain Is a Receptor for the Second Messenger c-di-GMP: THE PilZ DOMAIN PROTEIN YcgR CONTROLS MOTILITY IN ENTEROBACTERIA J. Biol. Chem., October 13, 2006; 281(41): 30310 - 30314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Suzuki, P. Babitzke, S. R. Kushner, and T. Romeo Identification of a novel regulatory protein (CsrD) that targets the global regulatory RNAs CsrB and CsrC for degradation by RNase E Genes & Dev., September 15, 2006; 20(18): 2605 - 2617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kumagai, Z. Cheng, M. Lin, and Y. Rikihisa Biochemical Activities of Three Pairs of Ehrlichia chaffeensis Two-Component Regulatory System Proteins Involved in Inhibition of Lysosomal Fusion Infect. Immun., September 1, 2006; 74(9): 5014 - 5022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Levi and U. Jenal Holdfast Formation in Motile Swarmer Cells Optimizes Surface Attachment during Caulobacter crescentus Development. J. Bacteriol., July 1, 2006; 188(14): 5315 - 5318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Ashby and J. Houmard Cyanobacterial Two-Component Proteins: Structure, Diversity, Distribution, and Evolution Microbiol. Mol. Biol. Rev., June 1, 2006; 70(2): 472 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Pruss, C. Besemann, A. Denton, and A. J. Wolfe A Complex Transcription Network Controls the Early Stages of Biofilm Development by Escherichia coli J. Bacteriol., June 1, 2006; 188(11): 3731 - 3739. [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Galperin Structural classification of bacterial response regulators: diversity of output domains and domain combinations. J. Bacteriol., June 1, 2006; 188(12): 4169 - 4182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Goymer, S. G. Kahn, J. G. Malone, S. M. Gehrig, A. J. Spiers, and P. B. Rainey Adaptive Divergence in Experimental Populations of Pseudomonas fluorescens. II. Role of the GGDEF Regulator WspR in Evolution and Development of the Wrinkly Spreader Phenotype Genetics, June 1, 2006; 173(2): 515 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Ryan, Y. Fouhy, J. F. Lucey, L. C. Crossman, S. Spiro, Y.-W. He, L.-H. Zhang, S. Heeb, M. Camara, P. Williams, et al. Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover PNAS, April 25, 2006; 103(17): 6712 - 6717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Thormann, S. Duttler, R. M. Saville, M. Hyodo, S. Shukla, Y. Hayakawa, and A. M. Spormann Control of Formation and Cellular Detachment from Shewanella oneidensis MR-1 Biofilms by Cyclic di-GMP. J. Bacteriol., April 1, 2006; 188(7): 2681 - 2691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Da Re and J.-M. Ghigo A CsgD-Independent Pathway for Cellulose Production and Biofilm Formation in Escherichia coli. J. Bacteriol., April 1, 2006; 188(8): 3073 - 3087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Mendez-Ortiz, M. Hyodo, Y. Hayakawa, and J. Membrillo-Hernandez Genome-wide Transcriptional Profile of Escherichia coli in Response to High Levels of the Second Messenger 3',5'-Cyclic Diguanylic Acid J. Biol. Chem., March 24, 2006; 281(12): 8090 - 8099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Camilli and B. L. Bassler Bacterial small-molecule signaling pathways. Science, February 24, 2006; 311(5764): 1113 - 1116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Amikam and M. Y. Galperin PilZ domain is part of the bacterial c-di-GMP binding protein Bioinformatics, January 1, 2006; 22(1): 3 - 6. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Karatan, T. R. Duncan, and P. I. Watnick NspS, a Predicted Polyamine Sensor, Mediates Activation of Vibrio cholerae Biofilm Formation by Norspermidine J. Bacteriol., November 1, 2005; 187(21): 7434 - 7443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Hickman, D. F. Tifrea, and C. S. Harwood A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels PNAS, October 4, 2005; 102(40): 14422 - 14427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Simm, J. D. Fetherston, A. Kader, U. Romling, and R. D. Perry Phenotypic Convergence Mediated by GGDEF-Domain-Containing Proteins J. Bacteriol., October 1, 2005; 187(19): 6816 - 6823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Waite, A. Papakonstantinopoulou, E. Littler, and M. A. Curtis Transcriptome Analysis of Pseudomonas aeruginosa Growth: Comparison of Gene Expression in Planktonic Cultures and Developing and Mature Biofilms J. Bacteriol., September 15, 2005; 187(18): 6571 - 6576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Christen, B. Christen, M. Folcher, A. Schauerte, and U. Jenal Identification and Characterization of a Cyclic di-GMP-specific Phosphodiesterase and Its Allosteric Control by GTP J. Biol. Chem., September 2, 2005; 280(35): 30829 - 30837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Schmidt, D. A. Ryjenkov, and M. Gomelsky The Ubiquitous Protein Domain EAL Is a Cyclic Diguanylate-Specific Phosphodiesterase: Enzymatically Active and Inactive EAL Domains J. Bacteriol., July 15, 2005; 187(14): 4774 - 4781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. SAXENA and R. M. BROWN JR Cellulose Biosynthesis: Current Views and Evolving Concepts Ann. Bot., July 1, 2005; 96(1): 9 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. R. Karaolis, M. H. Rashid, R. Chythanya, W. Luo, M. Hyodo, and Y. Hayakawa c-di-GMP (3'-5'-Cyclic Diguanylic Acid) Inhibits Staphylococcus aureus Cell-Cell Interactions and Biofilm Formation Antimicrob. Agents Chemother., March 1, 2005; 49(3): 1029 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Ryjenkov, M. Tarutina, O. V. Moskvin, and M. Gomelsky Cyclic Diguanylate Is a Ubiquitous Signaling Molecule in Bacteria: Insights into Biochemistry of the GGDEF Protein Domain J. Bacteriol., March 1, 2005; 187(5): 1792 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Kuchma, J. P. Connolly, and G. A. O'Toole A Three-Component Regulatory System Regulates Biofilm Maturation and Type III Secretion in Pseudomonas aeruginosa J. Bacteriol., February 15, 2005; 187(4): 1441 - 1454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kanbe, S. Shibata, Y. Umino, U. Jenal, and S.-I. Aizawa Protease susceptibility of the Caulobacter crescentus flagellar hook-basal body: a possible mechanism of flagellar ejection during cell differentiation Microbiology, February 1, 2005; 151(2): 433 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Armitage, I. B. Holland, U. Jenal, and B. Kenny "Neural Networks" in Bacteria: Making Connections J. Bacteriol., January 1, 2005; 187(1): 26 - 36. [Full Text] [PDF]
|
|
|
|
|
|
S. Hou, J. H. Saw, K. S. Lee, T. A. Freitas, C. Belisle, Y. Kawarabayasi, S. P. Donachie, A. Pikina, M. Y. Galperin, E. V. Koonin, et al. Genome sequence of the deep-sea {gamma}-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy PNAS, December 28, 2004; 101(52): 18036 - 18041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chan, R. Paul, D. Samoray, N. C. Amiot, B. Giese, U. Jenal, and T. Schirmer Structural basis of activity and allosteric control of diguanylate cyclase PNAS, December 7, 2004; 101(49): 17084 - 17089. [Abstract] [Full Text] [PDF]
|
|
