![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
RESEARCH COMMUNICATION
University of Pennsylvania, School of Veterinary Medicine, Department of Animal Biology, Philadelphia, Pennsylvania 19104, USA
We found that mammalian Polycomb group (PcG) protein YY1 can bind to Polycomb response elements in Drosophila embryos and can recruit other PcG proteins to DNA. PcG recruitment results in deacetylation and methylation of histone H3. In a CtBP mutant background, recruitment of PcG proteins and concomitant histone modifications do not occur. Surprisingly, YY1 DNA binding in vivo is also ablated. CtBP mutation does not result in YY1 degradation or transport from the nucleus, suggesting a mechanism whereby YY1 DNA binding ability is masked. These results reveal a new role for CtBP in controlling YY1 DNA binding and recruitment of PcG proteins to DNA.
[Keywords: YY1; Polycomb, CtBP; transcription; PRE]
Received June 2, 2004; revised version accepted September 9, 2004.
Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1228204.
1 Corresponding author.
E-MAIL atchison{at}vet.upenn.edu; FAX (215) 573-5189.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Alpatov, Y. Shi, G. C. Munguba, B. Moghimi, J.-H. Joo, J. Bungert, and S. P. Sugrue Corepressor CtBP and Nuclear Speckle Protein Pnn/DRS Differentially Modulate Transcription and Splicing of the E-Cadherin Gene Mol. Cell. Biol., March 1, 2008; 28(5): 1584 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Xi, Y. Yu, Y. Fu, J. Foley, A. Halees, and Z. Weng Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1 Genome Res., June 1, 2007; 17(6): 798 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Deng, M. Wan, and G. Sui PIASy-Mediated Sumoylation of Yin Yang 1 Depends on Their Interaction but Not the RING Finger Mol. Cell. Biol., May 15, 2007; 27(10): 3780 - 3792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Calame and M. Atchison YY1 helps to bring loose ends together Genes & Dev., May 15, 2007; 21(10): 1145 - 1152. [Full Text] [PDF]
|
|
|
|
|
|
H. Liu, M. Schmidt-Supprian, Y. Shi, E. Hobeika, N. Barteneva, H. Jumaa, R. Pelanda, M. Reth, J. Skok, K. Rajewsky, et al. Yin Yang 1 is a critical regulator of B-cell development Genes & Dev., May 15, 2007; 21(10): 1179 - 1189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. H. Wilkinson, K. Park, and M. L. Atchison Polycomb recruitment to DNA in vivo by the YY1 REPO domain PNAS, December 19, 2006; 103(51): 19296 - 19301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. R. Quinlan, A. Verger, A. Kwok, S. H. Y. Lee, J. Perdomo, M. Nardini, M. Bolognesi, and M. Crossley Role of the C-Terminal Binding Protein PXDLS Motif Binding Cleft in Protein Interactions and Transcriptional Repression Mol. Cell. Biol., November 1, 2006; 26(21): 8202 - 8213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Kobrossy, M. Rastegar, and M. Featherstone Interplay between Chromatin and Trans-acting Factors Regulating the Hoxd4 Promoter during Neural Differentiation J. Biol. Chem., September 8, 2006; 281(36): 25926 - 25939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Squazzo, H. O'Geen, V. M. Komashko, S. R. Krig, V. X. Jin, S.-w. Jang, R. Margueron, D. Reinberg, R. Green, and P. J. Farnham Suz12 binds to silenced regions of the genome in a cell-type-specific manner Genome Res., July 1, 2006; 16(7): 890 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Blastyak, R. K. Mishra, F. Karch, and H. Gyurkovics Efficient and Specific Targeting of Polycomb Group Proteins Requires Cooperative Interaction between Grainyhead and Pleiohomeotic Mol. Cell. Biol., February 15, 2006; 26(4): 1434 - 1444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Triantis, D. E. Trancikova, M. W. G. Looman, F. C. Hartgers, R. A. J. Janssen, and G. J. Adema Identification and Characterization of DC-SCRIPT, a Novel Dendritic Cell-Expressed Member of the Zinc Finger Family of Transcriptional Regulators J. Immunol., January 15, 2006; 176(2): 1081 - 1089. [Abstract] [Full Text] [PDF]
|
|
