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REVIEW
1 Division of Molecular Genetics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands; 2 Biotech Research & Innovation Centre, Symbion Science Park, 2100 Copenhagen, Denmark
Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional regulation locally and globally via modifications of the DNA and by modification or rearrangement of nucleosomes. Epigenetic gene regulation collaborates with genetic alterations in cancer development. This is evident from every aspect of tumor biology including cell growth and differentiation, cell cycle control, DNA repair, angiogenesis, migration, and evasion of host immunosurveillance. In contrast to genetic cancer causes, the possibility of reversing epigenetic codes may provide new targets for therapeutic intervention.
[Keywords: Epigenetics; cancer; chromatin; histone code; polycomb; SET domain proteins]
3 E-MAIL anders.lund{at}bric.dk; FAX 45-39179669.
4 E-MAIL m.v.lohuizen{at}nki.nl; FAX 31-205122011.
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