.gif?ad=16248&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RESEARCH PAPER
1 MPI fuer molekulare Genetik, 14195 Berlin, Germany; 2 Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA; 3 MPI fuer Medizinische Forschung, 69120 Heidelberg, Germany
Environmental cues transduced by an endocrine network converge on Caenorhabditis elegans nuclear receptor DAF-12 to mediate arrest at dauer diapause or continuous larval development. In adults, DAF-12 selects long-lived or short-lived modes. How these organismal choices are molecularly specified is unknown. Here we show that coregulator DIN-1 and DAF-12 physically and genetically interact to instruct organismal fates. Homologous to human corepressor SHARP, DIN-1 comes in long (L) and short (S) isoforms, which are nuclear localized but have distinct functions. DIN-1L has embryonic and larval developmental roles. DIN-1S, along with DAF-12, regulates lipid metabolism, larval stage-specific programs, diapause, and longevity. Epistasis experiments reveal that din-1S acts in the dauer pathways downstream of lipophilic hormone, insulin/IGF, and TGF
signaling, the same point as daf-12. We propose that the DIN-1S/DAF-12 complex serves as a molecular switch that implements slow life history alternatives in response to diminished hormonal signals.
[Keywords: Nuclear receptor; coregulator; aging; dauer; heterochrony]
Received June 8, 2004; revised version accepted July 7, 2004.
Supplemental material is available at http://www.genesdev.org.
4 Corresponding author. E-MAIL aantebi{at}bcm.tmc.edu; FAX (713) 798-4161.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Fielenbach and A. Antebi C. elegans dauer formation and the molecular basis of plasticity Genes & Dev., August 15, 2008; 22(16): 2149 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Patel, A. Garza-Garcia, M. Nanji, J. J. McElwee, D. Ackerman, P. C. Driscoll, and D. Gems Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor Genetics, February 1, 2008; 178(2): 931 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gerisch, V. Rottiers, D. Li, D. L. Motola, C. L. Cummins, H. Lehrach, D. J. Mangelsdorf, and A. Antebi A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling PNAS, March 20, 2007; 104(12): 5014 - 5019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Baumeister, E. Schaffitzel, and M. Hertweck Endocrine signaling in Caenorhabditis elegans controls stress response and longevity. J. Endocrinol., August 1, 2006; 190(2): 191 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-F. Ruaud and J.-L. Bessereau Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans Development, June 1, 2006; 133(11): 2211 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taubert, M. R. Van Gilst, M. Hansen, and K. R. Yamamoto A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes & Dev., May 1, 2006; 20(9): 1137 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Gershenfeld, R. A. Philibert, and G. W. Boehm Looking Forward in Geriatric Anxiety and Depression: Implications of Basic Science for the Future Am J Geriatr Psychiatry, December 1, 2005; 13(12): 1027 - 1040. [Abstract] [Full Text] [PDF]
|
|
