![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
REVIEW
1 IFOM Foundation—The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy; 2 The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, University of Cambridge, Cambridge CB2 1QR, UK
In response to DNA damage, cells engage a complex set of events that together comprise the DNA-damage response (DDR). These events bring about the repair of the damage and also slow down or halt cell cycle progression until the damage has been removed. In stark contrast, the ends of linear chromosomes, telomeres, are generally not perceived as DNA damage by the cell even though they terminate the DNA double-helix. Nevertheless, it has become clear over the past few years that many proteins involved in the DDR, particularly those involved in responding to DNA double-strand breaks, also play key roles in telomere maintenance. In this review, we discuss the current knowledge of both the telomere and the DDR, and then propose an integrated model for the events associated with the metabolism of DNA ends in these two distinct physiological contexts.
[Keywords: Telomere; DNA-damage response; checkpoint; senescence; DNA repair]
3 These authors contributed equally to this work.
4 E-MAIL dadda{at}ifom-firc.it; FAX 39-02-574303-231.
5 E-MAIL s.jackson{at}gurdon.cam.ac.uk; FAX 44-1223-334089.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. M. Raynaud, S. J. Jang, P. Nuciforo, S. Lantuejoul, E. Brambilla, N. Mounier, K. A. Olaussen, F. Andre, L. Morat, L. Sabatier, et al. Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions Ann. Onc., July 17, 2008; (2008) mdn405v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yan, X.-P. Yang, Y.-S. Kim, and A. M. Jetten RAP80 Responds to DNA Damage Induced by Both Ionizing Radiation and UV Irradiation and Is Phosphorylated at Ser205 Cancer Res., June 1, 2008; 68(11): 4269 - 4276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Subramanian, B. A. Moser, and T. M. Nakamura Recombination-Based Telomere Maintenance Is Dependent on Tel1-MRN and Rap1 and Inhibited by Telomerase, Taz1, and Ku in Fission Yeast Mol. Cell. Biol., March 1, 2008; 28(5): 1443 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Qian, J. Zhang, B. Yan, and X. Chen DEC1, a Basic Helix-Loop-Helix Transcription Factor and a Novel Target Gene of the p53 Family, Mediates p53-dependent Premature Senescence J. Biol. Chem., February 1, 2008; 283(5): 2896 - 2905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Chen, C. N. Hales, and S. E. Ozanne DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res., December 3, 2007; 35(22): 7417 - 7428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Vespa, R. T. Warrington, P. Mokros, J. Siroky, and D. E. Shippen ATM regulates the length of individual telomere tracts in Arabidopsis PNAS, November 13, 2007; 104(46): 18145 - 18150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Rossignol, S. Collier, M. Bush, P. Shaw, and J. H. Doonan Arabidopsis POT1A interacts with TERT-V(I8), an N-terminal splicing variant of telomerase J. Cell Sci., October 15, 2007; 120(20): 3678 - 3687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Viscardi, D. Bonetti, H. Cartagena-Lirola, G. Lucchini, and M. P. Longhese MRX-dependent DNA Damage Response to Short Telomeres Mol. Biol. Cell, August 1, 2007; 18(8): 3047 - 3058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hirano and K. Sugimoto Cdc13 Telomere Capping Decreases Mec1 Association but Does Not Affect Tel1 Association with DNA Ends Mol. Biol. Cell, June 1, 2007; 18(6): 2026 - 2036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Boerckel, D. Walker, and S. Ahmed The Caenorhabditis elegans Rad17 Homolog HPR-17 Is Required for Telomere Replication Genetics, May 1, 2007; 176(1): 703 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Multani and S. Chang WRN at telomeres: implications for aging and cancer J. Cell Sci., March 1, 2007; 120(5): 713 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Grandin and M. Charbonneau Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA Nucleic Acids Res., February 16, 2007; 35(3): 822 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Glover, S. Alsford, C. Beattie, and D. Horn Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest Nucleic Acids Res., February 16, 2007; 35(3): 872 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Larose, N. Laterreur, G. Ghazal, J. Gagnon, R. J. Wellinger, and S. A. Elela RNase III-dependent Regulation of Yeast Telomerase J. Biol. Chem., February 16, 2007; 282(7): 4373 - 4381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kedde, C. le Sage, A. Duursma, E. Zlotorynski, B. van Leeuwen, W. Nijkamp, R. Beijersbergen, and R. Agami Telomerase-independent Regulation of ATR by Human Telomerase RNA J. Biol. Chem., December 29, 2006; 281(52): 40503 - 40514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. C. De Souza, S. B. Hashmi, K. P. Horn, and S. A. Osmani A Point Mutation in the Aspergillus nidulans sonBNup98 Nuclear Pore Complex Gene Causes Conditional DNA Damage Sensitivity Genetics, December 1, 2006; 174(4): 1881 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Churikov, C. Wei, and C. M. Price Vertebrate POT1 Restricts G-Overhang Length and Prevents Activation of a Telomeric DNA Damage Checkpoint but Is Dispensable for Overhang Protection. Mol. Cell. Biol., September 1, 2006; 26(18): 6971 - 6982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ciapponi, G. Cenci, and M. Gatti The Drosophila Nbs Protein Functions in Multiple Pathways for the Maintenance of Genome Stability Genetics, July 1, 2006; 173(3): 1447 - 1454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Michelson, S. Rosenstein, and T. Weinert A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpoint Genes & Dev., November 1, 2005; 19(21): 2546 - 2559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tanaka, M. S. Mendonca, P. S. Bradshaw, D. J. Hoelz, L. H. Malkas, M. S. Meyn, and D. Gilley DNA damage-induced phosphorylation of the human telomere-associated protein TRF2 PNAS, October 25, 2005; 102(43): 15539 - 15544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Bi, D. Srikanta, L. Fanti, S. Pimpinelli, R. Badugu, R. Kellum, and Y. S. Rong Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance PNAS, October 18, 2005; 102(42): 15167 - 15172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Vespa, M. Couvillion, E. Spangler, and D. E. Shippen ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis Genes & Dev., September 15, 2005; 19(18): 2111 - 2115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, N. Erdmann, R. J. Giannone, J. Wu, M. Gomez, and Y. Liu An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres PNAS, July 19, 2005; 102(29): 10256 - 10260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. LeBel and R. J. Wellinger Telomeres: what's new at your end? J. Cell Sci., July 1, 2005; 118(13): 2785 - 2788. [Full Text] [PDF]
|
|
|
|
|
|
K. Masutomi, R. Possemato, J. M. Y. Wong, J. L. Currier, Z. Tothova, J. B. Manola, S. Ganesan, P. M. Lansdorp, K. Collins, and W. C. Hahn The telomerase reverse transcriptase regulates chromatin state and DNA damage responses PNAS, June 7, 2005; 102(23): 8222 - 8227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Y. Ting, Y. Yu, B. Pohorelic, S. P. Lees-Miller, and T. L. Beattie Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase Nucleic Acids Res., April 11, 2005; 33(7): 2090 - 2098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Shears Telomere maintenance by intracellular signals: New kid on the block? PNAS, February 8, 2005; 102(6): 1811 - 1812. [Full Text] [PDF]
|
|
|
|
|
|
G. Maga, K. Ramadan, Giada. A. Locatelli, I. Shevelev, S. Spadari, and U. Hubscher DNA Elongation by the Human DNA Polymerase {lambda} Polymerase and Terminal Transferase Activities Are Differentially Coordinated by Proliferating Cell Nuclear Antigen and Replication Protein A J. Biol. Chem., January 21, 2005; 280(3): 1971 - 1981. [Abstract] [Full Text] [PDF]
|
|
