![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Abstract
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear hormone receptor expressed predominantly in adipose tissue, where it plays a central role in the control of adipocyte gene expression and differentiation. Because there are two additional PPAR isoforms, PPARalpha and PPARdelta, and these are also expressed at some level in certain adipose depots, we have compared directly the adipogenic potential of all three receptors. Ectopically expressed PPARgamma powerfully induces adipogenesis at a morphological and molecular level in response to a number of PPARgamma activators. PPARalpha is less adipogenic but is able to induce significant differentiation in response to strong PPARalpha activators. Expression and activation of PPARdelta did not stimulate adipogenesis. Of the three PPARs, only PPARgamma can cooperate with C/EBPalpha in the promotion of adipogenesis. To begin to investigate the functional basis for the differential adipogenic activity of the PPAR isoforms, we have examined their ability to bind to several PPAR DNA response sequences. Compared with PPARalpha and PPARdelta, PPARgamma shows preferential binding to two well-characterized regulatory sequences derived from a fat-specific gene, ARE6 and ARE7. These data strongly suggest that PPARgamma is the predominant receptor regulating adipogenesis; however, they also suggest that PPARalpha may play a role in differentiation of certain adipose depots in response to a different set of physiologic activators or in certain disease states.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Ruan, F. Zheng, and Y. Guan PPARs and the kidney in metabolic syndrome Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1032 - F1047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, Y. Mu, H. Li, N. Ding, Q. Wang, Y. Wang, S. Wang, and N. Wang Peroxisome Proliferator-Activated Receptor-{gamma} Gene: A Key Regulator of Adipocyte Differentiation in Chickens Poult. Sci., February 1, 2008; 87(2): 226 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. S. Santos, L. R. Fernandes, E. G. Mario, A. V. M. Ferreira, L. C. J. Porto, J. I. Alvarez-Leite, L. M. Botion, M. Bader, N. Alenina, and R. A. S. Santos Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism Diabetes, February 1, 2008; 57(2): 340 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. H. Yu, S. C. Wu, W. T. K. Cheng, H. J. Mersmann, and S. T. Ding Ectopic expression of porcine peroxisome proliferator-activated receptor {delta} regulates adipogenesis in mouse myoblasts J Anim Sci, January 1, 2008; 86(1): 64 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Nielsen, L. Grontved, H. G. Stunnenberg, and S. Mandrup Peroxisome Proliferator-Activated Receptor Subtype- and Cell-Type-Specific Activation of Genomic Target Genes upon Adenoviral Transgene Delivery Mol. Cell. Biol., August 1, 2006; 26(15): 5698 - 5714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hummasti and P. Tontonoz The Peroxisome Proliferator-Activated Receptor N-Terminal Domain Controls Isotype-Selective Gene Expression and Adipogenesis Mol. Endocrinol., June 1, 2006; 20(6): 1261 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Standiford, V. G. Keshamouni, and R. C. Reddy Peroxisome Proliferator-activated Receptor-{gamma} as a Regulator of Lung Inflammation and Repair Proceedings of the ATS, October 1, 2005; 2(3): 226 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ravnskjaer, M. Boergesen, B. Rubi, J. K. Larsen, T. Nielsen, J. Fridriksson, P. Maechler, and S. Mandrup Peroxisome Proliferator-Activated Receptor {alpha} (PPAR{alpha}) Potentiates, whereas PPAR{gamma} Attenuates, Glucose-Stimulated Insulin Secretion in Pancreatic {beta}-Cells Endocrinology, August 1, 2005; 146(8): 3266 - 3276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Li and C. K. Glass PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis J. Lipid Res., December 1, 2004; 45(12): 2161 - 2173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Bility, J. T. Thompson, R. H. McKee, R. M. David, J. H. Butala, J. P. Vanden Heuvel, and J. M. Peters Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors (PPARs) by Phthalate Monoesters Toxicol. Sci., November 1, 2004; 82(1): 170 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Guan Peroxisome Proliferator-Activated Receptor Family and Its Relationship to Renal Complications of the Metabolic Syndrome J. Am. Soc. Nephrol., November 1, 2004; 15(11): 2801 - 2815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tonelli, W. Li, P. Kishore, U. B. Pajvani, E. Kwon, C. Weaver, P. E. Scherer, and M. Hawkins Mechanisms of Early Insulin-Sensitizing Effects of Thiazolidinediones in Type 2 Diabetes Diabetes, June 1, 2004; 53(6): 1621 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Sharma, A. Pradeep, R. G. Pestell, and B. Rana Peroxisome Proliferator-activated Receptor {gamma} Activation Modulates Cyclin D1 Transcription via {beta}-Catenin-independent and cAMP-response Element-binding Protein-dependent Pathways in Mouse Hepatocytes J. Biol. Chem., April 23, 2004; 279(17): 16927 - 16938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Giusti, C. Verdumo, M. Suter, R. C. Gaillard, P. Burckhardt, and F. Pralong Expression of Peroxisome Proliferator-Activated Receptor-{gamma}1 and Peroxisome Proliferator-Activated Receptor-{gamma}2 in Visceral and Subcutaneous Adipose Tissue of Obese Women Diabetes, July 1, 2003; 52(7): 1673 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Jeon, J. A. Kim, S. H. Kwon, S. W. Kim, K. S. Park, S.-W. Park, S. Y. Kim, and C. S. Shin Activation of Peroxisome Proliferator-activated Receptor-{gamma} Inhibits the Runx2-mediated Transcription of Osteocalcin in Osteoblasts J. Biol. Chem., June 20, 2003; 278(26): 23270 - 23277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Aleo, G. R. Lundeen, D. K. Blackwell, W. M. Smith, G. L. Coleman, S. W. Stadnicki, and W. M. Kluwe Mechanism and Implications of Brown Adipose Tissue Proliferation in Rats and Monkeys Treated with the Thiazolidinedione Darglitazone, a Potent Peroxisome Proliferator-Activated Receptor-{gamma} Agonist J. Pharmacol. Exp. Ther., June 1, 2003; 305(3): 1173 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Barbier, L. Villeneuve, V. Bocher, C. Fontaine, I. P. Torra, C. Duhem, V. Kosykh, J.-C. Fruchart, C. Guillemette, and B. Staels The UDP-glucuronosyltransferase 1A9 Enzyme Is a Peroxisome Proliferator-activated Receptor alpha and gamma Target Gene J. Biol. Chem., April 11, 2003; 278(16): 13975 - 13983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-Q. Tang, T. C. Otto, and M. D. Lane Mitotic clonal expansion: A synchronous process required for adipogenesis PNAS, January 7, 2003; 100(1): 44 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shen, E. Yoshida, W. Yan, T. Kawamoto, K. Suardita, Y. Koyano, K. Fujimoto, M. Noshiro, and Y. Kato Basic Helix-loop-helix Protein DEC1 Promotes Chondrocyte Differentiation at the Early and Terminal Stages J. Biol. Chem., December 13, 2002; 277(51): 50112 - 50120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. OKADA, S. F. YAN, and D. J. PINSKY Peroxisome proliferator-activated receptor-{gamma} (PPAR-{gamma}) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets FASEB J, December 1, 2002; 16(14): 1861 - 1868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bishop-Bailey, T. Hla, and T. D. Warner Intimal Smooth Muscle Cells as a Target for Peroxisome Proliferator-Activated Receptor-{gamma} Ligand Therapy Circ. Res., August 9, 2002; 91(3): 210 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sethi, O. Ziouzenkova, H. Ni, D. D. Wagner, J. Plutzky, and T. N. Mayadas Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPARalpha Blood, July 30, 2002; 100(4): 1340 - 1346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Helledie, L. Grontved, S. S. Jensen, P. Kiilerich, L. Rietveld, T. Albrektsen, M. S. Boysen, J. Nohr, L. K. Larsen, J. Fleckner, et al. The Gene Encoding the Acyl-CoA-binding Protein Is Activated by Peroxisome Proliferator-activated Receptor gamma through an Intronic Response Element Functionally Conserved between Humans and Rodents J. Biol. Chem., July 19, 2002; 277(30): 26821 - 26830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tamori, J. Masugi, N. Nishino, and M. Kasuga Role of Peroxisome Proliferator-Activated Receptor-{gamma} in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes Diabetes, July 1, 2002; 51(7): 2045 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. C. Yang, Q. Xiong, H. Enslen, R. J. Davis, and C.-W. Chow Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases Mol. Cell. Biol., June 1, 2002; 22(11): 3892 - 3904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Valyasevi, D. A. Harteneck, C. M. Dutton, and R. S. Bahn Stimulation of Adipogenesis, Peroxisome Proliferator-Activated Receptor-{gamma} (PPAR{gamma}), and Thyrotropin Receptor by PPAR{gamma} Agonist in Human Orbital Preadipocyte Fibroblasts J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2352 - 2358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shi, M. Hon, and R. M. Evans The peroxisome proliferator-activated receptor delta , an integrator of transcriptional repression and nuclear receptor signaling PNAS, February 20, 2002; (2002) 52707099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Smith, L. Koumas, A. Gagnon, A. Bell, G. D. Sempowski, R. P. Phipps, and A. Sorisky Orbital Fibroblast Heterogeneity May Determine the Clinical Presentation of Thyroid-Associated Ophthalmopathy J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 385 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Barak, D. Liao, W. He, E. S. Ong, M. C. Nelson, J. M. Olefsky, R. Boland, and R. M. Evans Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer PNAS, December 21, 2001; (2001) 12610299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kishida, I. Shimomura, H. Nishizawa, N. Maeda, H. Kuriyama, H. Kondo, M. Matsuda, H. Nagaretani, N. Ouchi, K. Hotta, et al. Enhancement of the Aquaporin Adipose Gene Expression by a Peroxisome Proliferator-activated Receptor gamma J. Biol. Chem., December 14, 2001; 276(51): 48572 - 48579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yu and J. E. Mertz Critical Roles of Nuclear Receptor Response Elements in Replication of Hepatitis B Virus J. Virol., December 1, 2001; 75(23): 11354 - 11364. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. M. Gregoire Adipocyte Differentiation: From Fibroblast to Endocrine Cell Experimental Biology and Medicine, December 1, 2001; 226(11): 997 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. de Souza, M. Eckhardt, K. Gagen, M. Dong, W. Chen, D. Laurent, and B. F. Burkey Effects of Pioglitazone on Adipose Tissue Remodeling Within the Setting of Obesity and Insulin Resistance Diabetes, August 1, 2001; 50(8): 1863 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Ntambi and K. Young-Cheul Adipocyte Differentiation and Gene Expression J. Nutr., December 1, 2000; 130 (12): 3122S - 3126S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. DeLuca, T. W. Doebber, L. J. Kelly, R. K. Kemp, S. Molon-Noblot, S. P. Sahoo, J. Ventre, M. S. Wu, J. M. Peters, F. J. Gonzalez, et al. Evidence for Peroxisome Proliferator-Activated Receptor (PPAR)alpha -Independent Peroxisome Proliferation: Effects of PPARgamma /delta -Specific Agonists in PPARalpha -Null Mice Mol. Pharmacol., September 1, 2000; 58(3): 470 - 476. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. G. Kroll, P. Sarraf, L. Pecciarini, C.-J. Chen, E. Mueller, B. M. Spiegelman, and J. A. Fletcher PAX8-PPARgamma 1 Fusion in Oncogene Human Thyroid Carcinoma Science, August 25, 2000; 289(5483): 1357 - 1360. [Abstract] [Full Text]
|
|
|
|
|
|
M.-C. Vohl, P. Lepage, D. Gaudet, C. G. Brewer, C. Bétard, P. Perron, G. Houde, C. Cellier, J. M. Faith, J.-P. Després, et al. Molecular scanning of the human PPARa gene: association of the L162V mutation with hyperapobetalipoproteinemia J. Lipid Res., June 1, 2000; 41(6): 945 - 952. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. D. Rosen, C. J. Walkey, P. Puigserver, and B. M. Spiegelman Transcriptional regulation of adipogenesis Genes & Dev., June 1, 2000; 14(11): 1293 - 1307. [Full Text]
|
|
|
|
 |
|
 S. Engeli, R. Negrel, and A. M. Sharma Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System Hypertension, June 1, 2000; 35(6): 1270 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Y. Oh, K. M. Min, J. H. Chung, Y.-K. Min, M.-S. Lee, K.-W. Kim, and M.-K. Lee Significance of Pro12Ala Mutation in Peroxisome Proliferator-Activated Receptor-{gamma}2 in Korean Diabetic and Obese Subjects J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 1801 - 1804. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Thieringer, J. E. Fenyk-Melody, C. B. Le Grand, B. A. Shelton, P. A. Detmers, E. P. Somers, L. Carbin, D. E. Moller, S. D. Wright, and J. Berger Activation of Peroxisome Proliferator-Activated Receptor {gamma} Does Not Inhibit IL-6 or TNF-{alpha} Responses of Macrophages to Lipopolysaccharide In Vitro or In Vivo J. Immunol., January 15, 2000; 164(2): 1046 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. L. Wang, J. Oosterhof, and N. Duarte Peroxisome proliferator-activated receptor {gamma} C161->T polymorphism and coronary artery disease Cardiovasc Res, December 1, 1999; 44(3): 588 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Desvergne and W. Wahli Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism Endocr. Rev., October 1, 1999; 20(5): 649 - 688. [Abstract] [Full Text]
|
|
|
|
|
|
D. Deplewski and R. L. Rosenfield Growth Hormone and Insulin-Like Growth Factors Have Different Effects on Sebaceous Cell Growth and Differentiation Endocrinology, September 1, 1999; 140(9): 4089 - 4094. [Abstract] [Full Text]
|
|
|
|
|
|
Q.-Q. Tang and M. D. Lane Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation Genes & Dev., September 1, 1999; 13(17): 2231 - 2241. [Abstract] [Full Text]
|
|
|
|
|
|
P. R. Devchand, A. K. Hihi, M. Perroud, W.-D. D. Schleuning, B. M. Spiegelman, and W. Wahli Chemical Probes That Differentially Modulate Peroxisome Proliferator-activated Receptor alpha and BLTR, Nuclear and Cell Surface Receptors for Leukotriene B4 J. Biol. Chem., August 13, 1999; 274(33): 23341 - 23348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Guardiola-Diaz, S. Rehnmark, N. Usuda, T. Albrektsen, D. Feltkamp, J.-A. Gustafsson, and S. E. H. Alexson Rat Peroxisome Proliferator-activated Receptors and Brown Adipose Tissue Function during Cold Acclimatization J. Biol. Chem., August 13, 1999; 274(33): 23368 - 23377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bastie, D. Holst, D. Gaillard, C. Jehl-Pietri, and P. A. Grimaldi Expression of Peroxisome Proliferator-activated Receptor PPARdelta Promotes Induction of PPARgamma and Adipocyte Differentiation in 3T3C2 Fibroblasts J. Biol. Chem., July 30, 1999; 274(31): 21920 - 21925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Edvardsson, M. Bergström, M. Alexandersson, K. Bamberg, B. Ljung, and B. Dahllöf Rosiglitazone (BRL49653), a PPAR{gamma}-selective agonist, causes peroxisome proliferator-like liver effects in obese mice J. Lipid Res., July 1, 1999; 40(7): 1177 - 1184. [Abstract] [Full Text]
|
|
|
|
|
|
D. Bishop-Bailey and T. Hla Endothelial Cell Apoptosis Induced by the Peroxisome Proliferator-activated Receptor (PPAR) Ligand 15-Deoxy-Delta 12,14-prostaglandin J2 J. Biol. Chem., June 11, 1999; 274(24): 17042 - 17048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Morrison and S. R. Farmer Role of PPARgamma in Regulating a Cascade Expression of Cyclin-dependent Kinase Inhibitors, p18(INK4c) and p21(Waf1/Cip1), during Adipogenesis J. Biol. Chem., June 11, 1999; 274(24): 17088 - 17097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Heinlein, H.-J. Ting, S. Yeh, and C. Chang Identification of ARA70 as a Ligand-enhanced Coactivator for the Peroxisome Proliferator-activated Receptor gamma J. Biol. Chem., June 4, 1999; 274(23): 16147 - 16152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. El-Jack, J. K. Hamm, P. F. Pilch, and S. R. Farmer Reconstitution of Insulin-sensitive Glucose Transport in Fibroblasts Requires Expression of Both PPARgamma and C/EBPalpha J. Biol. Chem., March 19, 1999; 274(12): 7946 - 7951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Berger, M. D. Leibowitz, T. W. Doebber, A. Elbrecht, B. Zhang, G. Zhou, C. Biswas, C. A. Cullinan, N. S. Hayes, Y. Li, et al. Novel Peroxisome Proliferator-activated Receptor (PPAR) gamma and PPARdelta Ligands Produce Distinct Biological Effects J. Biol. Chem., March 5, 1999; 274(10): 6718 - 6725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. King, E. Hu, D. F. Harris, P. Sarraf, B. M. Spiegelman, and T. M. Roberts DEF-1, a Novel Src SH3 Binding Protein That Promotes Adipogenesis in Fibroblastic Cell Lines Mol. Cell. Biol., March 1, 1999; 19(3): 2330 - 2337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Marx, T. Bourcier, G. K. Sukhova, P. Libby, and J. Plutzky PPAR{gamma} Activation in Human Endothelial Cells Increases Plasminogen Activator Inhibitor Type-1 Expression : PPAR{gamma} as a Potential Mediator in Vascular Disease Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 546 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Zhou and D. J. Waxman Cross-talk between Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) and Peroxisome Proliferator-activated Receptor-alpha (PPARalpha ) Signaling Pathways. GROWTH HORMONE INHIBITION OF PPARalpha TRANSCRIPTIONAL ACTIVITY MEDIATED BY STAT5b J. Biol. Chem., January 29, 1999; 274(5): 2672 - 2681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 |
