![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
Abstract
Dynamic epithelial reorganization is essential for morphogenesis of various organs. In Drosophila embryos, for example the Malpighian tubule is generated by cellular rearrangement of a preexisting epithelium and the tracheal network is formed by outgrowth, branching, and fusion of epithelial vesicles. Here we report that the previously identified locus shotgun (shg) encodes DE-cadherin, an epithelial cell-cell adhesion molecule of the classic cadherin type and that zygotic shg mutations rather specifically impair processes of the dynamic epithelial morphogenesis. In the mutants, the Malpighian tubule disintegrated into small spherical structures, and the tracheal network formation was blocked in selected steps. The malformation of these organs could be rescued by overexpression of DE-cadherin cDNA under a heat shock promoter. Unexpectedly, the zygotic null condition did not severely affect general epithelial organization; most epithelial tissues maintained not only their cell-cell associations but also their apicobasal polarity in the mutants. The zygotic null mutant retained a certain level of maternally derived DE-cadherin molecules until the end of embryogenesis. These results suggest that zygotic DE-cadherin expression is critical for the rearrangement processes of epithelial cells, whereas the maternally derived DE-cadherin may serve only for the maintenance of the static architecture of the epithelia.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Santiago-Martinez, N. H. Soplop, R. Patel, and S. G. Kramer Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation J. Cell Biol., July 28, 2008; 182(2): 241 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shindo, H. Wada, M. Kaido, M. Tateno, T. Aigaki, L. Tsuda, and S. Hayashi Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis Development, April 1, 2008; 135(7): 1355 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gorfinkiel and A. M. Arias Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in Drosophila J. Cell Sci., September 15, 2007; 120(18): 3289 - 3298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Cordero, D. E. Larson, C. R. Craig, R. Hays, and R. Cagan Dynamic Decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina Development, May 15, 2007; 134(10): 1861 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Jiang and S. T. Crews dysfusion Transcriptional Control of Drosophila Tracheal Migration, Adhesion, and Fusion. Mol. Cell. Biol., September 1, 2006; 26(17): 6547 - 6556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Mirkovic and M. Mlodzik Cooperative activities of Drosophila DE-Cadherin and DN-Cadherin regulate the cell motility process of ommatidial rotation Development, September 1, 2006; 133(17): 3283 - 3293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cela and M. Llimargas Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila Development, August 15, 2006; 133(16): 3115 - 3125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wodarz, D. B. Stewart, W. J. Nelson, and R. Nusse Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells J. Cell Sci., June 15, 2006; 119(12): 2425 - 2434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. Kiener, D. M. Lee, S. K. Agarwal, and M. B. Brenner Cadherin-11 Induces Rheumatoid Arthritis Fibroblast-Like Synoviocytes to Form Lining Layers in Vitro Am. J. Pathol., May 1, 2006; 168(5): 1486 - 1499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. Kiener, C. S. Stipp, P. G. Allen, J. M.G. Higgins, and M. B. Brenner The Cadherin-11 Cytoplasmic Juxtamembrane Domain Promotes {alpha}-Catenin Turnover at Adherens Junctions and Intercellular Motility Mol. Biol. Cell, May 1, 2006; 17(5): 2366 - 2376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lehmann, H. Lechner, B. Loer, M. Knieps, S. Herrmann, M. Famulok, R. Bauer, and M. Hoch Heteromerization of Innexin Gap Junction Proteins Regulates Epithelial Tissue Organization in Drosophila Mol. Biol. Cell, April 1, 2006; 17(4): 1676 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. Mathews, D. Ong, A. B. Milutinovich, and M. Van Doren Zinc transport activity of Fear of Intimacy is essential for proper gonad morphogenesis and DE-cadherin expression Development, March 15, 2006; 133(6): 1143 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pilot, J.-M. Philippe, C. Lemmers, J.-P. Chauvin, and T. Lecuit Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation Development, February 15, 2006; 133(4): 711 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Fox, C. C. F. Homem, S. H. Myster, F. Wang, E. E. Bain, and M. Peifer Rho1 regulates Drosophila adherens junctions independently of p120ctn Development, November 1, 2005; 132(21): 4819 - 4831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pacquelet and P. Rorth Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion J. Cell Biol., August 29, 2005; 170(5): 803 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Maretzky, K. Reiss, A. Ludwig, J. Buchholz, F. Scholz, E. Proksch, B. de Strooper, D. Hartmann, and P. Saftig ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and {beta}-catenin translocation PNAS, June 28, 2005; 102(26): 9182 - 9187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takahashi, F. Takahashi, K. Ui-Tei, T. Kojima, and K. Saigo Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila Development, June 1, 2005; 132(11): 2547 - 2559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Grzeschik and E. Knust IrreC/rst-mediated cell sorting during Drosophila pupal eye development depends on proper localisation of DE-cadherin Development, May 1, 2005; 132(9): 2035 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Pinheiro and D. J. Montell Requirement for Par-6 and Bazooka in Drosophila border cell migration Development, November 1, 2004; 131(21): 5243 - 5251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Devenport and N. H. Brown Morphogenesis in the absence of integrins: mutation of both Drosophila {beta} subunits prevents midgut migration Development, November 1, 2004; 131(21): 5405 - 5415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Mruk and C. Y. Cheng Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis Endocr. Rev., October 1, 2004; 25(5): 747 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Brumby, J. Secombe, J. Horsfield, M. Coombe, N. Amin, D. Coates, R. Saint, and H. Richardson A Genetic Screen for Dominant Modifiers of a cyclin E Hypomorphic Mutation Identifies Novel Regulators of S-Phase Entry in Drosophila Genetics, September 1, 2004; 168(1): 227 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hoffmans and K. Basler Identification and in vivo role of the Armadillo-Legless interaction Development, September 1, 2004; 131(17): 4393 - 4400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Rodriguez The dachsous gene, a member of the cadherin family, is required for Wg-dependent pattern formation in the Drosophila wing disc Development, July 1, 2004; 131(13): 3195 - 3206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bauer, C. Lehmann, J. Martini, F. Eckardt, and M. Hoch Gap Junction Channel Protein Innexin 2 Is Essential for Epithelial Morphogenesis in the Drosophila Embryo Mol. Biol. Cell, June 1, 2004; 15(6): 2992 - 3004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Cox and J. Hardin Sticky worms: adhesion complexes in C. elegans J. Cell Sci., April 15, 2004; 117(10): 1885 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Williams, B. MacIver, E. A. Klipfell, and G. H. Thomas The C-terminal domain of Drosophila {beta}Heavy-spectrin exhibits autonomous membrane association and modulates membrane area J. Cell Sci., February 15, 2004; 117(5): 771 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lee, S. Lee, A. D. Zadeh, and P. A. Kolodziej Distinct sites in E-cadherin regulate different steps in Drosophila tracheal tube fusion Development, December 15, 2003; 130(24): 5989 - 5999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Pagliarini and T. Xu A Genetic Screen in Drosophila for Metastatic Behavior Science, November 14, 2003; 302(5648): 1227 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Paul, M. Ternet, P. M. Salvaterra, and G. J. Beitel The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system Development, October 15, 2003; 130(20): 4963 - 4974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Jenkins, J. M. McCaffery, and M. Van Doren Drosophila E-cadherin is essential for proper germ cell-soma interaction during gonad morphogenesis Development, September 15, 2003; 130(18): 4417 - 4426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. McDonald, E. M. Pinheiro, and D. J. Montell PVF1, a PDGF/VEGF homolog, is sufficient to guide border cells and interacts genetically with Taiman Development, August 1, 2003; 130(15): 3469 - 3478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Van Doren, W. R. Mathews, M. Samuels, L. A. Moore, H. T. Broihier, and R. Lehmann fear of intimacy encodes a novel transmembrane protein required for gonad morphogenesis in Drosophila Development, June 1, 2003; 130(11): 2355 - 2364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Masai, Z. Lele, M. Yamaguchi, A. Komori, A. Nakata, Y. Nishiwaki, H. Wada, H. Tanaka, Y. Nojima, M. Hammerschmidt, et al. N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites Development, June 1, 2003; 130(11): 2479 - 2494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Rawls and T. Wolff Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye Development, May 1, 2003; 130(9): 1877 - 1887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dumstrei, F. Wang, and V. Hartenstein Role of DE-Cadherin in Neuroblast Proliferation, Neural Morphogenesis, and Axon Tract Formation in Drosophila Larval Brain Development J. Neurosci., April 15, 2003; 23(8): 3325 - 3335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chihara, K. Kato, M. Taniguchi, J. Ng, and S. Hayashi Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila Development, April 1, 2003; 130(7): 1419 - 1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gonzalez-Reyes Stem cells, niches and cadherins: a view from Drosophila J. Cell Sci., March 15, 2003; 116(6): 949 - 954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Magie, D. Pinto-Santini, and S. M. Parkhurst Rho1 interacts with p120ctn and {alpha}-catenin, and regulates cadherin-based adherens junction components in Drosophila Development, March 10, 2003; 129(16): 3771 - 3782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lee and P. A. Kolodziej The plakin Short Stop and the RhoA GTPase are required for E-cadherin-dependent apical surface remodeling during tracheal tube fusion Development, March 5, 2003; 129(6): 1509 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Myster, R. Cavallo, C. T. Anderson, D. T. Fox, and M. Peifer Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component J. Cell Biol., February 3, 2003; 160(3): 433 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pacquelet, L. Lin, and P. Rorth Binding site for p120/{delta}-catenin is not required for Drosophila E-cadherin function in vivo J. Cell Biol., February 3, 2003; 160(3): 313 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Song and T. Xie From the Cover: DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary PNAS, November 12, 2002; 99(23): 14813 - 14818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Y. Cheng and D. D. Mruk Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development Physiol Rev, October 1, 2002; 82(4): 825 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Dumstrei, F. Wang, D. Shy, U. Tepass, and V. Hartenstein Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis Development, September 1, 2002; 129(17): 3983 - 3994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-K. Sang and D. F. Ready Eyes closed, a Drosophila p47 homolog, is essential for photoreceptor morphogenesis Development, January 1, 2002; 129(1): 143 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Cox, S. A. Seyfried, L. Y. Jan, and Y. N. Jan Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary PNAS, December 4, 2001; 98(25): 14475 - 14480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Akhtar and N. A. Hotchin RAC1 Regulates Adherens Junctions through Endocytosis of E-Cadherin Mol. Biol. Cell, April 1, 2001; 12(4): 847 - 862. [Abstract] [Full Text]
|
|
|
|
|
|
H Oda and S Tsukita Real-time imaging of cell-cell adherens junctions reveals that Drosophila mesoderm invagination begins with two phases of apical constriction of cells J. Cell Sci., January 2, 2001; 114(3): 493 - 501. [Abstract] [PDF]
|
|
|
|
|
|
R. T. Cox, D. G. McEwen, D. L. Myster, R. J. Duronio, J. Loureiro, and M. Peifer A Screen for Mutations That Suppress the Phenotype of Drosophila armadillo, the {beta}-Catenin Homolog Genetics, August 1, 2000; 155(4): 1725 - 1740. [Abstract] [Full Text]
|
|
|
|
|
|
M Llimargas Wingless and its signalling pathway have common and separable functions during tracheal development Development, January 10, 2000; 127(20): 4407 - 4417. [Abstract] [PDF]
|
|
|
|
|
|
T Chihara and S Hayashi Control of tracheal tubulogenesis by Wingless signaling Development, January 10, 2000; 127(20): 4433 - 4442. [Abstract] [PDF]
|
|
|
|
|
|
D. C. Zarnescu and G. H. Thomas Apical Spectrin Is Essential for Epithelial Morphogenesis but Not Apicobasal Polarity in Drosophila J. Cell Biol., September 6, 1999; 146(5): 1075 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Spradling, D. Stern, A. Beaton, E. J. Rhem, T. Laverty, N. Mozden, S. Misra, and G. M. Rubin The Berkeley Drosophila Genome Project Gene Disruption Project: Single P-Element Insertions Mutating 25% of Vital Drosophila Genes Genetics, September 1, 1999; 153(1): 135 - 177. [Abstract] [Full Text]
|
|
|
|
|
|
T. L. Le, A. S. Yap, and J. L. Stow Recycling of E-Cadherin: A Potential Mechanism for Regulating Cadherin Dynamics J. Cell Biol., July 12, 1999; 146(1): 219 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Niewiadomska, D. Godt, and U. Tepass DE-Cadherin Is Required for Intercellular Motility during Drosophila Oogenesis J. Cell Biol., February 8, 1999; 144(3): 533 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Chae, M. Kim, J. Goo, S Collier, D Gubb, J Charlton, P. Adler, and W. Park The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family Development, January 12, 1999; 126(23): 5421 - 5429. [Abstract] [PDF]
|
|
|
|
|
|
T Ikeya and S Hayashi Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea Development, January 10, 1999; 126(20): 4455 - 4463. [Abstract] [PDF]
|
|
|
|
|
|
|
