![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Laboratory of Molecular Genetics, Tsukuba Life Science Center, Tsukuba, Japan.
Abstract
CBP (CREB-binding protein) is a transcriptional coactivator of CREB (cAMP response element-binding) protein, which is directly phosphorylated by PKA (cAMP-dependent protein kinase A). CBP interacts with the activated phosphorylated form of CREB but not with the nonphosphorylated form. We report here that CBP is also a coactivator of the c-myb proto-oncogene product (c-Myb), which is a sequence-specific transcriptional activator. CBP directly binds to the region containing the transcriptional activation domain of c-Myb in a phosphorylation-independent manner in vitro. The domain of CBP that touches c-Myb is also required for binding to CREB. A c-Myb/CBP complex in vivo was demonstrated by a yeast two-hybrid assay. CBP stimulates the c-Myb-dependent transcriptional activation. Conversely, the expression of antisense RNA of CBP represses c-Myb-induced transcriptional activation. In addition, adenovirus EIA, which binds to CBP, inhibits c-Myb-induced transcriptional activation. Our data thus identify CBP as a coactivator of c-Myb. These results suggest that CBP functions as a coactivator for more transcriptional activators than were thought previously.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  B. R. Calvi, B. A. Byrnes, and A. J. Kolpakas Conservation of Epigenetic Regulation, ORC Binding and Developmental Timing of DNA Replication Origins in the Genus Drosophila Genetics, November 1, 2007; 177(3): 1291 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Gombart, J. Grewal, and H. P. Koeffler ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBP{epsilon} and C/EBP{alpha} J. Leukoc. Biol., June 1, 2007; 81(6): 1535 - 1547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dai, T. Nakagami, H. Tanaka, T. Hitomi, and T. Takamatsu Cx43 Mediates TGF-beta Signaling through Competitive Smads Binding to Microtubules Mol. Biol. Cell, June 1, 2007; 18(6): 2264 - 2273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Deng, C. Liu, Y. Pei, X. Deng, L. Niu, and X. Cao Involvement of the Histone Acetyltransferase AtHAC1 in the Regulation of Flowering Time via Repression of FLOWERING LOCUS C in Arabidopsis Plant Physiology, April 1, 2007; 143(4): 1660 - 1668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sramko, J. Markus, J. Kabat, L. Wolff, and J. Bies Stress-induced Inactivation of the c-Myb Transcription Factor through Conjugation of SUMO-2/3 Proteins J. Biol. Chem., December 29, 2006; 281(52): 40065 - 40075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Morita, C. Kanei-Ishii, T. Nomura, and S. Ishii TRAF7 Sequesters c-Myb to the Cytoplasm by Stimulating Its Sumoylation Mol. Biol. Cell, November 1, 2005; 16(11): 5433 - 5444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kurahashi, T. Nomura, C. Kanei-Ishii, Y. Shinkai, and S. Ishii The Wnt-NLK Signaling Pathway Inhibits A-Myb Activity by Inhibiting the Association with Coactivator CBP and Methylating Histone H3 Mol. Biol. Cell, October 1, 2005; 16(10): 4705 - 4713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sano, H. Akimaru, T. Okamura, T. Nagao, M. Okada, and S. Ishii Drosophila Activating Transcription Factor-2 Is Involved in Stress Response via Activation by p38, but Not c-Jun NH2-Terminal Kinase Mol. Biol. Cell, June 1, 2005; 16(6): 2934 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Lei, F. Liu, and S. A. Ness Positive and negative regulation of c-Myb by cyclin D1, cyclin-dependent kinases, and p27 Kip1 Blood, May 15, 2005; 105(10): 3855 - 3861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tanikawa, T. Nomura, E. M. Macmillan, T. Shinagawa, W. Jin, K. Kokura, D. Baba, M. Shirakawa, T. J. Gonda, and S. Ishii p53 Suppresses c-Myb-induced trans-Activation and Transformation by Recruiting the Corepressor mSin3A J. Biol. Chem., December 31, 2004; 279(53): 55393 - 55400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kanei-Ishii, T. Nomura, J. Tanikawa, E. Ichikawa-Iwata, and S. Ishii Differential Sensitivity of v-Myb and c-Myb to Wnt-1-induced Protein Degradation J. Biol. Chem., October 22, 2004; 279(43): 44582 - 44589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Delgado, D. Pozo, and D. Ganea The Significance of Vasoactive Intestinal Peptide in Immunomodulation Pharmacol. Rev., June 1, 2004; 56(2): 249 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang and P. A. Insel The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells J. Biol. Chem., May 14, 2004; 279(20): 20858 - 20865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Chen, D. Liang, L. D. Fromm, and P. A. Overbeek Inhibition of Lens Fiber Cell Morphogenesis by Expression of a Mutant SV40 Large T Antigen That Binds CREB-binding Protein/p300 but Not pRb J. Biol. Chem., April 23, 2004; 279(17): 17667 - 17673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nomura, J. Tanikawa, H. Akimaru, C. Kanei-Ishii, E. Ichikawa-Iwata, M. M. Khan, H. Ito, and S. Ishii Oncogenic Activation of c-Myb Correlates with a Loss of Negative Regulation by TIF1{beta} and Ski J. Biol. Chem., April 16, 2004; 279(16): 16715 - 16726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kanei-Ishii, J. Ninomiya-Tsuji, J. Tanikawa, T. Nomura, T. Ishitani, S. Kishida, K. Kokura, T. Kurahashi, E. Ichikawa-Iwata, Y. Kim, et al. Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK Genes & Dev., April 1, 2004; 18(7): 816 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Yang, R. DeBeaumont, S. Zhou, and A. M. Naar The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator PNAS, February 24, 2004; 101(8): 2339 - 2344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-K. So, Y. Nie, Y. Song, G.-Y. Yang, S. Chen, C. Wei, L.-D. Wang, N. A. Doggett, and C. S. Yang Loss of Heterozygosity and Internal Tandem Duplication Mutations of the CBP Gene Are Frequent Events in Human Esophageal Squamous Cell Carcinoma Clin. Cancer Res., January 1, 2004; 10(1): 19 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Valls, X. de la Cruz, and M. A. Martinez-Balbas The SV40 T antigen modulates CBP histone acetyltransferase activity Nucleic Acids Res., June 15, 2003; 31(12): 3114 - 3122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-A Seong, K.-T. Kim, and H. Ha Enhancement of B-MYB Transcriptional Activity by ZPR9, a Novel Zinc Finger Protein J. Biol. Chem., March 7, 2003; 278(11): 9655 - 9662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zor, B. M. Mayr, H. J. Dyson, M. R. Montminy, and P. E. Wright Roles of Phosphorylation and Helix Propensity in the Binding of the KIX Domain of CREB-binding Protein by Constitutive (c-Myb) and Inducible (CREB) Activators J. Biol. Chem., October 25, 2002; 277(44): 42241 - 42248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-M. Huang and D. J. McCance Down Regulation of the Interleukin-8 Promoter by Human Papillomavirus Type 16 E6 and E7 through Effects on CREB Binding Protein/p300 and P/CAF J. Virol., July 29, 2002; 76(17): 8710 - 8721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Blobel CBP and p300: versatile coregulators with important roles in hematopoietic gene expression J. Leukoc. Biol., April 1, 2002; 71(4): 545 - 556. [Full Text] [PDF]
|
|
|
|
|
|
J. Bies, J. Markus, and L. Wolff Covalent Attachment of the SUMO-1 Protein to the Negative Regulatory Domain of the c-Myb Transcription Factor Modifies Its Stability and Transactivation Capacity J. Biol. Chem., March 8, 2002; 277(11): 8999 - 9009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yamamoto, F. Kihara-Negishi, T. Yamada, M. Suzuki, T. Nakano, and T. Oikawa Interaction between the Hematopoietic Ets Transcription Factor Spi-B and the Coactivator CREB-binding Protein Associated with Negative Cross-talk with c-Myb Cell Growth Differ., February 1, 2002; 13(2): 69 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Johnson, T. K. Johnson, M. Desler, T. A. Luster, T. Nowling, R. E. Lewis, and A. Rizzino Effects of B-Myb on Gene Transcription. PHOSPHORYLATION-DEPENDENT ACTIVITY AND ACETYLATION BY p300 J. Biol. Chem., February 1, 2002; 277(6): 4088 - 4097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Karafiat, M. Dvorakova, P. Pajer, J. Kralova, Z. Horejsi, V. Cermak, P. Bartunek, M. Zenke, and M. Dvorak The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors Blood, December 15, 2001; 98(13): 3668 - 3676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Nicot, R. Mahieux, C. Pise-Masison, J. Brady, A. Gessain, S. Yamaoka, and G. Franchini Human T-Cell Lymphotropic Virus Type 1 Tax Represses c-Myb-Dependent Transcription through Activation of the NF-{kappa}B Pathway and Modulation of Coactivator Usage Mol. Cell. Biol., November 1, 2001; 21(21): 7391 - 7402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Swenson, E. Holley-Guthrie, and S. C. Kenney Epstein-Barr Virus Immediate-Early Protein BRLF1 Interacts with CBP, Promoting Enhanced BRLF1 Transactivation J. Virol., July 1, 2001; 75(13): 6228 - 6234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Lazarova, M. Bordonaro, and A. C. Sartorelli Transcriptional Regulation of the Vitamin D3 Receptor Gene by ZEB Cell Growth Differ., June 1, 2001; 12(6): 319 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Lutz, A. Houzel-Charavel, C. Moog-Lutz, and Y. E. Cayre Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid Blood, April 15, 2001; 97(8): 2449 - 2456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Chen, Z. Deng, A. Y. Kim, G. A. Blobel, and P. M. Lieberman Stimulation of CREB Binding Protein Nucleosomal Histone Acetyltransferase Activity by a Class of Transcriptional Activators Mol. Cell. Biol., January 15, 2001; 21(2): 476 - 487. [Abstract] [Full Text]
|
|
|
|
|
|
M. D. Robek and L. Ratner Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction J. Virol., December 15, 2000; 74(24): 11988 - 11992. [Abstract] [Full Text]
|
|
|
|
|
|
H. Laser, C. Bongards, J. Schüller, S. Heck, N. Johnsson, and N. Lehming A new screen for protein interactions reveals that the Saccharomyces cerevisiae high mobility group proteins Nhp6A/B are involved in the regulation of the GAL1 promoter PNAS, November 22, 2000; (2000) 250400997. [Abstract] [Full Text]
|
|
|
|
|
|
S. Papoutsopoulou and R. Janknecht Phosphorylation of ETS Transcription Factor ER81 in a Complex with Its Coactivators CREB-Binding Protein and p300 Mol. Cell. Biol., October 1, 2000; 20(19): 7300 - 7310. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Tohkin, M. Fukuhara, G. Elizondo, S. Tomita, and F. J. Gonzalez Aryl Hydrocarbon Receptor Is Required for p300-Mediated Induction of DNA Synthesis by Adenovirus E1A Mol. Pharmacol., October 1, 2000; 58(4): 845 - 851. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Bryant, P. Mixon, M. Davidson, A. J. Bannister, T. Kouzarides, and J. H. Sinclair The Human Cytomegalovirus 86-Kilodalton Major Immediate-Early Protein Interacts Physically and Functionally with Histone Acetyltransferase P/CAF J. Virol., August 15, 2000; 74(16): 7230 - 7237. [Abstract] [Full Text]
|
|
|
|
|
|
R. H. Goodman and S. Smolik CBP/p300 in cell growth, transformation, and development Genes & Dev., July 1, 2000; 14(13): 1553 - 1577. [Full Text]
|
|
|
|
|
|
H. Homma, H. Kurachi, Y. Nishio, T. Takeda, T. Yamamoto, K. Adachi, K.-i. Morishige, M. Ohmichi, Y. Matsuzawa, and Y. Murata Estrogen Suppresses Transcription of Lipoprotein Lipase Gene. EXISTENCE OF A UNIQUE ESTROGEN RESPONSE ELEMENT ON THE LIPOPROTEIN LIPASE PROMOTER J. Biol. Chem., April 6, 2000; 275(15): 11404 - 11411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Stein, M. Montecino, A. J. van Wijnen, J. L. Stein, and J. B. Lian Nuclear Structure-Gene Expression Interrelationships: Implications for Aberrant Gene Expression in Cancer Cancer Res., April 1, 2000; 60(8): 2067 - 2076. [Abstract] [Full Text]
|
|
|
|
|
|
D. Lee, B. Lee, J. Kim, D. W. Kim, and J. Choe cAMP Response Element-binding Protein-binding Protein Binds to Human Papillomavirus E2 Protein and Activates E2-dependent Transcription J. Biol. Chem., March 15, 2000; 275(10): 7045 - 7051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-G. Ying, P. Proost, J. van Damme, M. Bruschi, M. Introna, and J. Golay Nucleolin, a Novel Partner for the Myb Transcription Factor Family That Regulates Their Activity J. Biol. Chem., February 11, 2000; 275(6): 4152 - 4158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Blobel CREB-binding protein and p300: molecular integrators of hematopoietic transcription Blood, February 1, 2000; 95(3): 745 - 755. [Full Text] [PDF]
|
|
|
|
|
|
A. A. Postigo and D. C. Dean Independent Repressor Domains in ZEB Regulate Muscle and T-Cell Differentiation Mol. Cell. Biol., December 1, 1999; 19(12): 7961 - 7971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jiang, H. Lu, R. L. Schiltz, C. A. Pise-Masison, V. V. Ogryzko, Y. Nakatani, and J. N. Brady PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner Mol. Cell. Biol., December 1, 1999; 19(12): 8136 - 8145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fujitani, Y. Kajimoto, T. Yasuda, T.-A. Matsuoka, H. Kaneto, Y. Umayahara, N. Fujita, H. Watada, J.-I. Miyazaki, Y. Yamasaki, et al. Identification of a Portable Repression Domain and an E1A-Responsive Activation Domain in Pax4: a Possible Role of Pax4 as a Transcriptional Repressor in the Pancreas Mol. Cell. Biol., December 1, 1999; 19(12): 8281 - 8291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kakita, K. Hasegawa, T. Morimoto, S. Kaburagi, H. Wada, and S. Sasayama p300 Protein as a Coactivator of GATA-5 in the Transcription of Cardiac-restricted Atrial Natriuretic Factor Gene J. Biol. Chem., November 26, 1999; 274(48): 34096 - 34102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Albanese, M. D'Amico, A. T. Reutens, M. Fu, G. Watanabe, R. J. Lee, R. N. Kitsis, B. Henglein, M. Avantaggiati, K. Somasundaram, et al. Activation of the cyclin D1 Gene by the E1A-associated Protein p300 through AP-1 Inhibits Cellular Apoptosis J. Biol. Chem., November 26, 1999; 274(48): 34186 - 34195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Adamson and S. Kenney The Epstein-Barr Virus BZLF1 Protein Interacts Physically and Functionally with the Histone Acetylase CREB-Binding Protein J. Virol., August 1, 1999; 73(8): 6551 - 6558. [Abstract] [Full Text]
|
|
|
|
|
|
W. H. McDonald, R. Ohi, N. Smelkova, D. Frendewey, and K. L. Gould Myb-Related Fission Yeast cdc5p Is a Component of a 40S snRNP-Containing Complex and Is Essential for Pre-mRNA Splicing Mol. Cell. Biol., August 1, 1999; 19(8): 5352 - 5362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Parker, M. Rivera, T. Zor, A. Henrion-Caude, I. Radhakrishnan, A. Kumar, L. H. Shapiro, P. E. Wright, M. Montminy, and P. K. Brindle Role of Secondary Structure in Discrimination between Constitutive and Inducible Activators Mol. Cell. Biol., August 1, 1999; 19(8): 5601 - 5607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-M. Wang, J. W. Dubendorff, C. H. Woo, and J. S. Lipsick Functional Analysis of Carboxy-Terminal Deletion Mutants of c-Myb J. Virol., July 1, 1999; 73(7): 5875 - 5886. [Abstract] [Full Text]
|
|
|
|
|
|
G. Jayaraman, R. Srinivas, C. Duggan, E. Ferreira, S. Swaminathan, K. Somasundaram, J. Williams, C. Hauser, M. Kurkinen, R. Dhar, et al. p300/cAMP-responsive Element-binding Protein Interactions with Ets-1 and Ets-2 in the Transcriptional Activation of the Human Stromelysin Promoter J. Biol. Chem., June 11, 1999; 274(24): 17342 - 17352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. K. Felzien, S. Farrell, J. C. Betts, R. Mosavin, and G. J. Nabel Specificity of Cyclin E-Cdk2, TFIIB, and E1A Interactions with a Common Domain of the p300 Coactivator Mol. Cell. Biol., June 1, 1999; 19(6): 4241 - 4246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kaspar, M. Dvorakova, J. Kralova, P. Pajer, Z. Kozmik, and M. Dvorak Myb-interacting Protein, ATBF1, Represses Transcriptional Activity of Myb Oncoprotein J. Biol. Chem., May 14, 1999; 274(20): 14422 - 14428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Oike, N. Takakura, A. Hata, T. Kaname, M. Akizuki, Y. Yamaguchi, H. Yasue, K. Araki, K.-i. Yamamura, and T. Suda Mice Homozygous for a Truncated Form of CREB-Binding Protein Exhibit Defects in Hematopoiesis and Vasculo-angiogenesis Blood, May 1, 1999; 93(9): 2771 - 2779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nakashima, M. Yanagisawa, H. Arakawa, N. Kimura, T. Hisatsune, M. Kawabata, K. Miyazono, and T. Taga Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300 Science, April 16, 1999; 284(5413): 479 - 482. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Sano, J. Harada, S. Tashiro, R. Gotoh-Mandeville, T. Maekawa, and S. Ishii ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-beta Signaling J. Biol. Chem., March 26, 1999; 274(13): 8949 - 8957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Dai, H. Akimaru, Y. Tanaka, T. Maekawa, M. Nakafuku, and S. Ishii Sonic Hedgehog-induced Activation of the Gli1 Promoter Is Mediated by GLI3 J. Biol. Chem., March 19, 1999; 274(12): 8143 - 8152. |
