![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Howard Hughes Medical Institute, University of California, San Francisco, 94143-0724, USA.
Abstract
Wing margin formation in Drosophila requires the Notch receptor and, in the dorsal compartment, one of its ligands, Serrate. We provide evidence that Delta, the other known ligand for Notch, is also essential for this process. Delta is required in ventral cells at the dorsal/ventral compartment boundary, where its expression is specifically elevated in second-instar wing discs during wing margin formation. Moreover, ectopic Delta expression induces wingless, vestigial, and cut and causes adult wing tissue outgrowth in the dorsal compartment. The effect is mediated by Notch, because loss of Notch activity suppresses Delta-induced ectopic wing outgrowth. Whereas ectopic expression of Notch or the truncated activated Notch induces cut in both dorsal and ventral compartments, ectopic Delta expression induces cut only in the dorsal compartment and ectopic Serrate induces cut only in the ventral compartment. These observations indicate that Notch-expressing cells in a given compartment have different responses to Delta and Serrate. We propose that Delta and Serrate function as compartment-specific signals in the wing disc, to activate Notch and induce downstream genes required for wing formation.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Bejarano, C. M. Luque, H. Herranz, G. Sorrosal, N. Rafel, T. T. Pham, and M. Milan A Gain-of-Function Suppressor Screen for Genes Involved in Dorsal-Ventral Boundary Formation in the Drosophila Wing Genetics, January 1, 2008; 178(1): 307 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zecca and G. Struhl Control of Drosophila wing growth by the vestigial quadrant enhancer Development, August 15, 2007; 134(16): 3011 - 3020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Geffers, K. Serth, G. Chapman, R. Jaekel, K. Schuster-Gossler, R. Cordes, D. B. Sparrow, E. Kremmer, S. L. Dunwoodie, T. Klein, et al. Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo J. Cell Biol., July 24, 2007; 178(3): 465 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Grammont Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis J. Cell Biol., April 9, 2007; 177(1): 139 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Grieder, I. Charlafti, U. Kloter, H. Jackle, U. Schafer, and W. J. Gehring Misexpression Screen in Drosophila melanogaster Aiming to Reveal Novel Factors Involved in Formation of Body Parts Genetics, April 1, 2007; 175(4): 1707 - 1718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Yu, D. X. Chen, Q. X. Zhou, N. Fang, and Z. L. Liu Effects of Histamine on Immunophenotype and Notch Signaling in Human HL-60 Leukemia Cells. Experimental Biology and Medicine, November 1, 2006; 231(10): 1633 - 1637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gonzalez, C. Chaouiya, and D. Thieffry Dynamical Analysis of the Regulatory Network Defining the Dorsal-Ventral Boundary of the Drosophila Wing Imaginal Disc Genetics, November 1, 2006; 174(3): 1625 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Janody and J. E. Treisman Actin capping protein {alpha} maintains vestigial-expressing cells within the Drosophila wing disc epithelium Development, September 1, 2006; 133(17): 3349 - 3357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Garces and S. Thor Specification of Drosophila aCC motoneuron identity by a genetic cascade involving even-skipped, grain and zfh1 Development, April 15, 2006; 133(8): 1445 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gause, J. C. Eissenberg, A. F. MacRae, M. Dorsett, Z. Misulovin, and D. Dorsett Nipped-A, the Tra1/TRRAP Subunit of the Drosophila SAGA and Tip60 Complexes, Has Multiple Roles in Notch Signaling during Wing Development. Mol. Cell. Biol., March 1, 2006; 26(6): 2347 - 2359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kwon, Z. Han, E. N. Olson, and D. Srivastava MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling PNAS, December 27, 2005; 102(52): 18986 - 18991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Major and K. D. Irvine Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing Development, September 1, 2005; 132(17): 3823 - 3833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Lai, F. Roegiers, X. Qin, Y. N. Jan, and G. M. Rubin The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Development, May 15, 2005; 132(10): 2319 - 2332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Adam and D. J. Montell A role for extra macrochaetae downstream of Notch in follicle cell differentiation Development, December 1, 2004; 131(23): 5971 - 5980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Vercauteren and H. J. Sutherland Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo Blood, October 15, 2004; 104(8): 2315 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kamimura, J. M. Rhodes, R. Ueda, M. McNeely, D. Shukla, K. Kimata, P. G. Spear, N. W. Shworak, and H. Nakato Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase J. Cell Biol., September 27, 2004; 166(7): 1069 - 1079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tabata and Y. Takei Morphogens, their identification and regulation Development, February 15, 2004; 131(4): 703 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lei, A. Xu, V. M. Panin, and K. D. Irvine An O-fucose site in the ligand binding domain inhibits Notch activation Development, December 29, 2003; 130(26): 6411 - 6421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ahmed, S. Chandra, M. Magarinos, and H. Vaessin echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway Development, December 22, 2003; 130(25): 6295 - 6304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. LaVoie and D. J. Selkoe The Notch Ligands, Jagged and Delta, Are Sequentially Processed by {alpha}-Secretase and Presenilin/{gamma}-Secretase and Release Signaling Fragments J. Biol. Chem., September 5, 2003; 278(36): 34427 - 34437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Lundell, H.-K. Lee, E. Perez, and L. Chadwell The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila Development, September 1, 2003; 130(17): 4109 - 4121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Janody, Z. Martirosyan, A. Benlali, and J. E. Treisman Two subunits of the Drosophila mediator complex act together to control cell affinity Development, August 15, 2003; 130(16): 3691 - 3701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, M. Fetchko, Z.-C. Lai, and N. E. Baker Scabrous and Gp150 are endosomal proteins that regulate Notch activity Development, July 1, 2003; 130(13): 2819 - 2827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, L. Li, K. D. Irvine, and N. E. Baker Notch activity in neural cells triggered by a mutant allele with altered glycosylation Development, July 1, 2003; 130(13): 2829 - 2840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Dansereau, M. D. Lunke, A. Finkielsztein, M. A. Russell, and W. J. Brook hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster Development, March 14, 2003; 129(24): 5553 - 5566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Umesono, Y. Hiromi, and Y. Hotta Context-dependent utilization of Notch activity in Drosophila glial determination Development, March 7, 2003; 129(10): 2391 - 2399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wu and S. M. Cohen Repression of Teashirt marks the initiation of wing development Development, March 7, 2003; 129(10): 2411 - 2418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Matsuno, M. Ito, K. Hori, F. Miyashita, S. Suzuki, N. Kishi, S. Artavanis-Tsakonas, and H. Okano Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling Development, March 4, 2003; 129(4): 1049 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Milan and S. M. Cohen A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing Development, February 1, 2003; 130(3): 553 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. H. Przemeck, U. Heinzmann, J. Beckers, and M. Hrabe de Angelis Node and midline defects are associated with left-right development in Delta1 mutant embryos Development, January 1, 2003; 130(1): 3 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Goulet, P. Watson, M. Poirier, L. Leduy, G. Berube, S. Meterissian, P. Jolicoeur, and A. Nepveu Characterization of a Tissue-specific CDP/Cux Isoform, p75, Activated in Breast Tumor Cells Cancer Res., November 15, 2002; 62(22): 6625 - 6633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Panin, L. Shao, L. Lei, D. J. Moloney, K. D. Irvine, and R. S. Haltiwanger Notch Ligands Are Substrates for Protein O-Fucosyltransferase-1 and Fringe J. Biol. Chem., August 9, 2002; 277(33): 29945 - 29952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Stollewerk Recruitment of cell groups through Delta/Notch signalling during spider neurogenesis Development, January 12, 2002; 129(23): 5339 - 5348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Pi, H.-J. Wu, and C.-T. Chien A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny Development, July 15, 2001; 128(14): 2699 - 2710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Grammont and K. D. Irvine fringe and Notch specify polar cell fate during Drosophila oogenesis Development, June 15, 2001; 128(12): 2243 - 2253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O'Keefe and J. Thomas Drosophila wing development in the absence of dorsal identity Development, January 3, 2001; 128(5): 703 - 710. [Abstract] [PDF]
|
|
|
|
|
|
J Treisman Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development Development, January 2, 2001; 128(4): 603 - 615. [Abstract] [PDF]
|
|
|
|
|
|
R. Nolo, L. A. Abbott, and H. J. Bellen Drosophila Lyra Mutations Are Gain-of-Function Mutations of senseless Genetics, January 1, 2001; 157(1): 307 - 315. [Abstract] [Full Text]
|
|
|
|
 |
|
 D Zhao, D Clyde, and M Bownes Expression of fringe is down regulated by Gurken/Epidermal Growth Factor Receptor signalling and is required for the morphogenesis of ovarian follicle cells J. Cell Sci., January 11, 2000; 113(21): 3781 - 3794. [Abstract] [PDF]
|
|
|
|
|
|
T Chihara and S Hayashi Control of tracheal tubulogenesis by Wingless signaling Development, January 10, 2000; 127(20): 4433 - 4442. [Abstract] [PDF]
|
|
|
|
|
|
T Klein, L Seugnet, M Haenlin, and A Martinez Arias Two different activities of Suppressor of Hairless during wing development in Drosophila Development, January 8, 2000; 127(16): 3553 - 3566. [Abstract] [PDF]
|
|
|
|
|
|
M Milan and S. Cohen Temporal regulation of apterous activity during development of the Drosophila wing Development, January 7, 2000; 127(14): 3069 - 3078. [Abstract] [PDF]
|
|
|
|
|
|
K Certel, A Hudson, S. Carroll, and W. Johnson Restricted patterning of vestigial expression in Drosophila wing imaginal discs requires synergistic activation by both Mad and the drifter POU domain transcription factor Development, January 7, 2000; 127(14): 3173 - 3183. [Abstract] [PDF]
|
|
|
|
|
|
N Lawrence, T Klein, K Brennan, and A Martinez Arias Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila Development, January 7, 2000; 127(14): 3185 - 3195. [Abstract] [PDF]
|
|
|
|
|
|
C Maurel-Zaffran and J. Treisman pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila Development, January 3, 2000; 127(5): 1007 - 1016. [Abstract] [PDF]
|
|
|
|
|
|
J. de Celis and S. Bray The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe Development, January 3, 2000; 127(6): 1291 - 1302. [Abstract] [PDF]
|
|
|
|
|
|
C. S. Wesley Notch and Wingless Regulate Expression of Cuticle Patterning Genes Mol. Cell. Biol., August 1, 1999; 19(8): 5743 - 5758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Artavanis-Tsakonas, M. D. Rand, and R. J. Lake Notch Signaling: Cell Fate Control and Signal Integration in Development Science, April 30, 1999; 284(5415): 770 - 776. [Abstract] [Full Text]
|
|
|
|
|
|
T Ikeya and S Hayashi Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea Development, January 10, 1999; 126(20): 4455 - 4463. [Abstract] [PDF]
|
|
|
|
|
|
S. Bishop, T Klein, A. Arias, and J. Couso Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch Development, January 7, 1999; 126(13): 2993 - 3003. [Abstract] [PDF]
|
|
|
|
|
|
M Llimargas The Notch pathway helps to pattern the tips of the Drosophila tracheal branches by selecting cell fates Development, January 6, 1999; 126(11): 2355 - 2364. [Abstract] [PDF]
|
|
|
|
|
|
R Nagaraj, A. Pickup, R Howes, K Moses, M Freeman, and U Banerjee Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial Development, January 2, 1999; 126(5): 975 - 985. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Kidd, T. Lieber, and M. W. Young Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos Genes & Dev., December 1, 1998; 12(23): 3728 - 3740. [Abstract] [Full Text]
|
|
|
|
|
|
M. Fostier, D. A. P. Evans, S. Artavanis-Tsakonas, and M. Baron Genetic Characterization of the Drosophila melanogaster Suppressor of deltex Gene: A Regulator of Notch Signaling Genetics, December 1, 1998; 150(4): 1477 - 1485. [Abstract] [Full Text]
|
|
|
|
|
|
M. Milán, F. J. Diaz-Benjumea, and S. M. Cohen Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function Genes & Dev., September 15, 1998; 12(18): 2912 - 2920. [Abstract] [Full Text]
|
|
|
|
|
|
C. Zeng, N. J. Justice, S. Abdelilah, Y.-M. Chan, L. Y. Jan, and Y. N. Jan The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development PNAS, September 1, 1998; 95(18): 10637 - 10642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Neumann and S. M. Cohen Boundary Formation in Drosophila Wing: Notch Activity Attenuated by the POU Protein Nubbin Science, July 17, 1998; 281(5375): 409 - 413. [Abstract] [Full Text]
|
|
|
|
|
|
I. Greenwald LIN-12/Notch signaling: lessons from worms and flies Genes & Dev., June 15, 1998; 12(12): 1751 - 1762. [Full Text]
|
|
|
|
|
|
B. Varnum-Finney, L. E. Purton, M. Yu, C. Brashem-Stein, D. Flowers, S. Staats, K. A. Moore, I. Le Roux, R. Mann, G. Gray, et al. The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells Blood, June 1, 1998; 91(11): 4084 - 4091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
