![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.
Abstract
The p130 protein shares extensive sequence similarity with pRB, the product of the retinoblastoma gene, and is a major E2F-associated protein in quiescent cells. To investigate its biological function, we have mutated p130 via gene targeting in the mouse. Homozygous mutation of p130 had little discernible effect on development or on the growth of mouse embryo fibroblasts in culture. Much of the E2F activity that normally associates with p130 in serum-starved mouse embryo fibroblasts associated instead with the highly related p107 protein. To determine whether p130 and p107 have overlapping biological roles, we produced mice having simultaneous inactivation of the p130 and p107 genes. Such mice exhibited deregulated chondrocyte growth, defective endochondral bone development, shortened limbs, and neonatal lethality. These findings indicate that p130 and p107 play an important role in limb development through their abilities to control chondrocyte proliferation. Thus, in certain settings p107 and p130 perform growth-regulatory functions that are not fulfilled by pRB.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Andreu-Vieyra, R. Chen, and M. M. Matzuk Conditional Deletion of the Retinoblastoma (Rb) Gene in Ovarian Granulosa Cells Leads to Premature Ovarian Failure Mol. Endocrinol., September 1, 2008; 22(9): 2141 - 2161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. David, K. B. Grandinetti, P. M. Finnerty, N. Simpson, G. C. Chu, and R. A. DePinho Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation PNAS, March 18, 2008; 105(11): 4168 - 4172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Blais, C. J.C. van Oevelen, R. Margueron, D. Acosta-Alvear, and B. D. Dynlacht Retinoblastoma tumor suppressor protein dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit J. Cell Biol., December 31, 2007; 179(7): 1399 - 1412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Rathi, M. T. Saenz Robles, and J. M. Pipas Enterocyte Proliferation and Intestinal Hyperplasia Induced by Simian Virus 40 T Antigen Require a Functional J Domain J. Virol., September 1, 2007; 81(17): 9481 - 9489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yeh, J. P. Miller, T. Gaur, T. D. Capellini, J. Nikolich-Zugich, C. de la Hoz, L. Selleri, T. G. Bromage, A. J. van Wijnen, G. S. Stein, et al. Cooperation between p27 and p107 during Endochondral Ossification Suggests a Genetic Pathway Controlled by p27 and p130 Mol. Cell. Biol., July 15, 2007; 27(14): 5161 - 5171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ahuja, P. Sdek, and W. R. MacLellan Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration Physiol Rev, April 1, 2007; 87(2): 521 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Wenzel, L. Wu, A. de Bruin, J.-L. Chong, W.-Y. Chen, G. Dureska, E. Sites, T. Pan, A. Sharma, K. Huang, et al. Rb is critical in a mammalian tissue stem cell population Genes & Dev., January 1, 2007; 21(1): 85 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Yoon, R. Pogue, D. A. Ovchinnikov, I. Yoshii, Y. Mishina, R. R. Behringer, and K. M. Lyons BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways Development, December 1, 2006; 133(23): 4667 - 4678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Mak, M.-H. Chen, T. F. Day, P.-T. Chuang, and Y. Yang Wnt/{beta}-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation Development, September 15, 2006; 133(18): 3695 - 3707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Soeiro, A. Mohamedali, H. M. Romanska, N. C. Lea, E. S. Child, J. Glassford, S. J. Orr, C. Roberts, K. N. Naresh, E.-N. Lalani, et al. p27Kip1 and p130 Cooperate To Regulate Hematopoietic Cell Proliferation In Vivo. Mol. Cell. Biol., August 1, 2006; 26(16): 6170 - 6184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Williams, T. Stewart, B. Li, R. Mulloy, D. Dimova, and M. Classon The Retinoblastoma Protein Is Required for Ras-Induced Oncogenic Transformation Mol. Cell. Biol., February 15, 2006; 26(4): 1170 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Haigis, J. Sage, J. Glickman, S. Shafer, and T. Jacks The Related Retinoblastoma (pRb) and p130 Proteins Cooperate to Regulate Homeostasis in the Intestinal Epithelium J. Biol. Chem., January 6, 2006; 281(1): 638 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Balciunaite, A. Spektor, N. H. Lents, H. Cam, H. te Riele, A. Scime, M. A. Rudnicki, R. Young, and B. D. Dynlacht Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells Mol. Cell. Biol., September 15, 2005; 25(18): 8166 - 8178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vidal, S. Zacharoulis, W. Guo, D. Shaffer, F. Giancotti, A. H. Bramley, C. de la Hoz, K. K. Jensen, D. Kato, D. D. MacDonald, et al. p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow PNAS, May 10, 2005; 102(19): 6890 - 6895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Batsche, P. Moschopoulos, J. Desroches, S. Bilodeau, and J. Drouin Retinoblastoma and the Related Pocket Protein p107 Act as Coactivators of NeuroD1 to Enhance Gene Transcription J. Biol. Chem., April 22, 2005; 280(16): 16088 - 16095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. MacLellan, A. Garcia, H. Oh, P. Frenkel, M. C. Jordan, K. P. Roos, and M. D. Schneider Overlapping Roles of Pocket Proteins in the Myocardium Are Unmasked by Germ Line Deletion of p130 plus Heart-Specific Deletion of Rb Mol. Cell. Biol., March 15, 2005; 25(6): 2486 - 2497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. X. Liu, N. Nath, S. P. Chellappan, and L. A. Greene Regulation of neuron survival and death by p130 and associated chromatin modifiers Genes & Dev., March 15, 2005; 19(6): 719 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Rodier, C. Makris, P. Coulombe, A. Scime, K. Nakayama, K. I. Nakayama, and S. Meloche p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2 J. Cell Biol., January 3, 2005; 168(1): 55 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Dannenberg, L. Schuijff, M. Dekker, M. van der Valk, and H. t. Riele Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130 Genes & Dev., December 1, 2004; 18(23): 2952 - 2962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Camarda, F. Siepi, D. Pajalunga, C. Bernardini, R. Rossi, A. Montecucco, E. Meccia, and M. Crescenzi A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells J. Cell Biol., November 8, 2004; 167(3): 417 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Litovchick, A. Chestukhin, and J. A. DeCaprio Glycogen Synthase Kinase 3 Phosphorylates RBL2/p130 during Quiescence Mol. Cell. Biol., October 15, 2004; 24(20): 8970 - 8980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Vanderluit, K. L. Ferguson, V. Nikoletopoulou, M. Parker, V. Ruzhynsky, T. Alexson, S. M. McNamara, D. S. Park, M. Rudnicki, and R. S. Slack p107 regulates neural precursor cells in the mammalian brain J. Cell Biol., September 13, 2004; 166(6): 853 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. MacPherson, J. Sage, T. Kim, D. Ho, M. E. McLaughlin, and T. Jacks Cell type-specific effects of Rb deletion in the murine retina Genes & Dev., July 15, 2004; 18(14): 1681 - 1694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ruiz, M. Santos, C. Segrelles, H. Leis, J. L. Jorcano, A. Berns, J. M. Paramio, and M. Vooijs Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis Development, June 1, 2004; 131(11): 2737 - 2748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wang, A. Woods, S. Sabari, L. Pagnotta, L.-A. Stanton, and F. Beier RhoA/ROCK Signaling Suppresses Hypertrophic Chondrocyte Differentiation J. Biol. Chem., March 26, 2004; 279(13): 13205 - 13214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Boulet and M. R. Capecchi Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod Development, January 15, 2004; 131(2): 299 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Marino, D. Hoogervoorst, S. Brandner, and A. Berns Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence Development, August 1, 2003; 130(15): 3359 - 3368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Sindermann, C. Kobbert, F. Bauer, A. Skaletz-Rorowski, H. Hohage, G. Plenz, G. Breithardt, and K. L. March Vascular ligation response is independent of p107: stressing the role of the related p130 Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H915 - H918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Dailey, E. Laplantine, R. Priore, and C. Basilico A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation J. Cell Biol., June 23, 2003; 161(6): 1053 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ruiz, C. Segrelles, A. Bravo, M. Santos, P. Perez, H. Leis, J. L. Jorcano, and J. M. Paramio Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130 Development, June 1, 2003; 130(11): 2341 - 2353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Scheijen, M. Bronk, T. van der Meer, and R. Bernards Constitutive E2F1 Overexpression Delays Endochondral Bone Formation by Inhibiting Chondrocyte Differentiation Mol. Cell. Biol., May 15, 2003; 23(10): 3656 - 3668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Stiewe, J. Stanelle, C. C. Theseling, B. Pollmeier, M. Beitzinger, and B. M. Putzer Inactivation of Retinoblastoma (RB) Tumor Suppressor by Oncogenic Isoforms of the p53 Family Member p73 J. Biol. Chem., April 11, 2003; 278(16): 14230 - 14236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Kohn, R. T. Bronson, E. Harlow, N. J. Dyson, and L. Yamasaki Dp1 is required for extra-embryonic development Development, April 1, 2003; 130(7): 1295 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Landsberg, J. E. Sero, P. S. Danielian, T. L. Yuan, E. Y. Lee, and J. A. Lees The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity PNAS, March 4, 2003; 100(5): 2456 - 2461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yang, L. Topol, H. Lee, and J. Wu Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation Development, March 1, 2003; 130(5): 1003 - 1015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Catchpole, F. Tavner, L. Le Cam, C. Sardet, and R. J. Watson A B-myb Promoter Corepressor Site Facilitates in Vivo Occupation of the Adjacent E2F Site by p107{middle dot}E2F and p130{middle dot}E2F Complexes J. Biol. Chem., October 4, 2002; 277(41): 39015 - 39024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Laplantine, F. Rossi, M. Sahni, C. Basilico, and D. Cobrinik FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest J. Cell Biol., August 19, 2002; 158(4): 741 - 750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Sullivan and J. M. Pipas T Antigens of Simian Virus 40: Molecular Chaperones for Viral Replication and Tumorigenesis Microbiol. Mol. Biol. Rev., June 1, 2002; 66(2): 179 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Sindermann, J. Smith, C. Kobbert, G. Plenz, A. Skaletz-Rorowski, J. L. Solomon, L. Fan, and K. L. March Direct evidence for the importance of p130 in injury response and arterial remodeling following carotid artery ligation Cardiovasc Res, June 1, 2002; 54(3): 676 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Rayman, Y. Takahashi, V. B. Indjeian, J.-H. Dannenberg, S. Catchpole, R. J. Watson, H. te Riele, and B. D. Dynlacht E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex Genes & Dev., April 15, 2002; 16(8): 933 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Rane, S. C. Cosenza, R. V. Mettus, and E. P. Reddy Germ Line Transmission of the Cdk4R24C Mutation Facilitates Tumorigenesis and Escape from Cellular Senescence Mol. Cell. Biol., January 15, 2002; 22(2): 644 - 656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jasinski, C. Riou-Khamlichi, O. Roche, C. Perennes, C. Bergounioux, and N. Glab The CDK inhibitor NtKIS1a is involved in plant development, endoreduplication and restores normal development of cyclin D3; 1-overexpressing plants J. Cell Sci., January 3, 2002; 115(5): 973 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Ehmann, H. A. Burnett, and S. L. Bachenheimer Pocket Protein p130/Rb2 Is Required for Efficient Herpes Simplex Virus Type 1 Gene Expression and Viral Replication J. Virol., August 1, 2001; 75(15): 7149 - 7160. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Huang, M. Jokela, J. Tuusa, S. Skog, K. Poikonen, and J. E. Syvaoja E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase {{epsilon}} B-subunit gene POLE2 Nucleic Acids Res., July 1, 2001; 29(13): 2810 - 2821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Paggi and A. Giordano Who Is the Boss in the Retinoblastoma Family? The Point of View of Rb2/p130, the Little Brother Cancer Res., June 1, 2001; 61(12): 4651 - 4654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yu. Nikitin, B. Shan, A. Flesken-Nikitin, K.-H. Chang, and W.-H. Lee The Retinoblastoma Gene Regulates Somatic Growth during Mouse Development Cancer Res., April 1, 2001; 61(7): 3110 - 3118. [Abstract] [Full Text]
|
|
|
|
|
|
H. Müller, A. P. Bracken, R. Vernell, M. C. Moroni, F. Christians, E. Grassilli, E. Prosperini, E. Vigo, J. D. Oliner, and K. Helin E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis Genes & Dev., February 1, 2001; 15(3): 267 - 285. [Abstract] [Full Text]
|
|
|
|
|
|
X. Ye, C. Zhu, and J. W. Harper A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene PNAS, February 1, 2001; (2001) 41596198. [Abstract] [Full Text]
|
|
|
|
|
|
J. Sage, G. J. Mulligan, L. D. Attardi, A. Miller, S. Chen, B. Williams, E. Theodorou, and T. Jacks Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization Genes & Dev., December 1, 2000; 14(23): 3037 - 3050. [Abstract] [Full Text]
|
|
|
|
|
|
J.-H. Dannenberg, A. van Rossum, L. Schuijff, and H. te Riele Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions Genes & Dev., December 1, 2000; 14(23): 3051 - 3064. [Abstract] [Full Text]
|
|
|
|
|
|
M. Classon, S. Salama, C. Gorka, R. Mulloy, P. Braun, and E. Harlow Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control PNAS, September 19, 2000; (2000) 190343497. [Abstract] [Full Text]
|
|
|
|
|
|
M. Classon, B. K. Kennedy, R. Mulloy, and E. Harlow Opposing roles of pRB and p107 in adipocyte differentiation PNAS, September 19, 2000; (2000) 190343597. [Abstract] [Full Text]
|
|
|
|
|
|
G. Vairo, T. J. Soos, T. M. Upton, J. Zalvide, J. A. DeCaprio, M. E. Ewen, A. Koff, and J. M. Adams Bcl-2 Retards Cell Cycle Entry through p27Kip1, pRB Relative p130, and Altered E2F Regulation Mol. Cell. Biol., July 1, 2000; 20(13): 4745 - 4753. [Abstract] [Full Text]
|
|
|
|
|
|
A. K. McElroy, R. S. Dwarakanath, and D. H. Spector Dysregulation of Cyclin E Gene Expression in Human Cytomegalovirus-Infected Cells Requires Viral Early Gene Expression and Is Associated with Changes in the Rb-Related Protein p130 J. Virol., May 1, 2000; 74(9): 4192 - 4206. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. M. Francesconi, A. E. K. Hutcheon, E.-H. Chung, A. C. Dalbone, N. C. Joyce, and J. D. Zieske Expression Patterns of Retinoblastoma and E2F Family Proteins during Corneal Development Invest. Ophthalmol. Vis. Sci., April 1, 2000; 41(5): 1054 - 1062. [Abstract] [Full Text]
|
|
|
|
|
|
R. M. Gill and P. A. Hamel Subcellular Compartmentalization of E2F Family Members Is Required for Maintenance of the Postmitotic State in Terminally Differentiated Muscle J. Cell Biol., March 20, 2000; 148(6): 1187 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Thomas, A Sunters, A Gentry, and A. Grigoriadis Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene J. Cell Sci., January 2, 2000; 113(3): 439 - 450. [Abstract] [PDF]
|
|
|
|
 |
|
 R. A. Levine and M. A. Fleischli Inactivation of p53 and Retinoblastoma Family Pathways in Canine Osteosarcoma Cell Lines Vet. Pathol., January 1, 2000; 37(1): 54 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
